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Proteoglycan fragments in joint fluid : Influence of arthrosis and inflammation

Dahlberg, Leif LU ; Ryd, Leif LU ; Heinegård, Dick LU and Lohmander, L. Stefan LU (1992) In Acta Orthopaedica 63(4). p.417-423
Abstract

We determined the concentration of proteoglycan fragments in knee joint fluid collected from knee-ligament injured patients more than 6 months after the trauma and from patients with acute pyrophosphate arthritis and arthrosis or with arthrosis only. Injured patients with normal or only mildly altered cartilage at arthroscopy and with normal radiographs, had twice the average concentration of healthy volunteers. Other injured patients with advanced, radiographic signs of arthrosis, had synovial fluid proteoglycan fragment concentrations within the range of healthy volunteers. Patients with pyrophosphate arthritis had the highest concentrations, substantially increased compared with both arthrosis patients, with or without knee injury... (More)

We determined the concentration of proteoglycan fragments in knee joint fluid collected from knee-ligament injured patients more than 6 months after the trauma and from patients with acute pyrophosphate arthritis and arthrosis or with arthrosis only. Injured patients with normal or only mildly altered cartilage at arthroscopy and with normal radiographs, had twice the average concentration of healthy volunteers. Other injured patients with advanced, radiographic signs of arthrosis, had synovial fluid proteoglycan fragment concentrations within the range of healthy volunteers. Patients with pyrophosphate arthritis had the highest concentrations, substantially increased compared with both arthrosis patients, with or without knee injury and healthy volunteers. Likewise, there was an inverse relation between the degree of arthrosis and the concentration of proteoglycan fragments in the joint fluid in patients with pyrophosphate arthritis and arthrosis or with arthrosis only. We conclude that synovial fluid levels of proteoglycan fragments are influenced by the mass of cartilage matrix remaining in the joint, the inflammatory activity in the joint, and the metabolic activity of the cartilage cells. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Orthopaedica
volume
63
issue
4
pages
7 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:0026646417
ISSN
1745-3674
DOI
10.3109/17453679209154758
language
English
LU publication?
yes
id
a0664c60-953a-406f-b55b-d0e2f468bd84
date added to LUP
2016-05-04 18:26:10
date last changed
2016-12-04 04:51:11
@misc{a0664c60-953a-406f-b55b-d0e2f468bd84,
  abstract     = {<p>We determined the concentration of proteoglycan fragments in knee joint fluid collected from knee-ligament injured patients more than 6 months after the trauma and from patients with acute pyrophosphate arthritis and arthrosis or with arthrosis only. Injured patients with normal or only mildly altered cartilage at arthroscopy and with normal radiographs, had twice the average concentration of healthy volunteers. Other injured patients with advanced, radiographic signs of arthrosis, had synovial fluid proteoglycan fragment concentrations within the range of healthy volunteers. Patients with pyrophosphate arthritis had the highest concentrations, substantially increased compared with both arthrosis patients, with or without knee injury and healthy volunteers. Likewise, there was an inverse relation between the degree of arthrosis and the concentration of proteoglycan fragments in the joint fluid in patients with pyrophosphate arthritis and arthrosis or with arthrosis only. We conclude that synovial fluid levels of proteoglycan fragments are influenced by the mass of cartilage matrix remaining in the joint, the inflammatory activity in the joint, and the metabolic activity of the cartilage cells. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.</p>},
  author       = {Dahlberg, Leif and Ryd, Leif and Heinegård, Dick and Lohmander, L. Stefan},
  issn         = {1745-3674},
  language     = {eng},
  number       = {4},
  pages        = {417--423},
  publisher    = {ARRAY(0x9166950)},
  series       = {Acta Orthopaedica},
  title        = {Proteoglycan fragments in joint fluid : Influence of arthrosis and inflammation},
  url          = {http://dx.doi.org/10.3109/17453679209154758},
  volume       = {63},
  year         = {1992},
}