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In vitro studies on the effect of in vivo zinc deficiency on the formation of glycos-aminoglycans in rat costal cartilage

Lohmander, Stefan LU ; Friberg, Ulf and Bergman, Bo (1972) In Acta Odontologica Scandinavica 30(1). p.89-96
Abstract

The effects of in vivo zinc deficiency and restricted food intake, on the in vitro synthesis of glycosaminoglycans of rib cartilage were studied in the rat. 35S-sulfate and 14C-glucosamine were used as precursors. The glycosaminoglycans were separated on microcolumns and specific radioactivities determined for the different fractions. Chemical analyses showed that zinc deficiency or reduced food intake did not cause any qualitative or quantitative changes in the glycosaminoglycans. The radioassays indicated that zinc deficiency and reduced food intake, alone or combined, caused a somewhat lowered synthetic rate of chondroitin sulfate. In the discussion it is underlined that it seems difficult to determine... (More)

The effects of in vivo zinc deficiency and restricted food intake, on the in vitro synthesis of glycosaminoglycans of rib cartilage were studied in the rat. 35S-sulfate and 14C-glucosamine were used as precursors. The glycosaminoglycans were separated on microcolumns and specific radioactivities determined for the different fractions. Chemical analyses showed that zinc deficiency or reduced food intake did not cause any qualitative or quantitative changes in the glycosaminoglycans. The radioassays indicated that zinc deficiency and reduced food intake, alone or combined, caused a somewhat lowered synthetic rate of chondroitin sulfate. In the discussion it is underlined that it seems difficult to determine conclusively the importance of zinc for the formation of the mucopolysaccharides through further in vivo deficiency studies, because of the difficulties to control and evaluate the inanition factor. © 1972 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cartilage, Deficiency diseases, Rats, Zinc
in
Acta Odontologica Scandinavica
volume
30
issue
1
pages
8 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:0015311646
ISSN
0001-6357
DOI
10.3109/00016357209004594
language
English
LU publication?
yes
id
a0700c30-8274-4460-8f27-8fabb7b7130f
date added to LUP
2016-05-04 12:36:16
date last changed
2016-11-14 09:42:48
@misc{a0700c30-8274-4460-8f27-8fabb7b7130f,
  abstract     = {<p>The effects of in vivo zinc deficiency and restricted food intake, on the in vitro synthesis of glycosaminoglycans of rib cartilage were studied in the rat. <sup>35</sup>S-sulfate and <sup>14</sup>C-glucosamine were used as precursors. The glycosaminoglycans were separated on microcolumns and specific radioactivities determined for the different fractions. Chemical analyses showed that zinc deficiency or reduced food intake did not cause any qualitative or quantitative changes in the glycosaminoglycans. The radioassays indicated that zinc deficiency and reduced food intake, alone or combined, caused a somewhat lowered synthetic rate of chondroitin sulfate. In the discussion it is underlined that it seems difficult to determine conclusively the importance of zinc for the formation of the mucopolysaccharides through further in vivo deficiency studies, because of the difficulties to control and evaluate the inanition factor. © 1972 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.</p>},
  author       = {Lohmander, Stefan and Friberg, Ulf and Bergman, Bo},
  issn         = {0001-6357},
  keyword      = {Cartilage,Deficiency diseases,Rats,Zinc},
  language     = {eng},
  number       = {1},
  pages        = {89--96},
  publisher    = {ARRAY(0x9c4a010)},
  series       = {Acta Odontologica Scandinavica},
  title        = {In vitro studies on the effect of in vivo zinc deficiency on the formation of glycos-aminoglycans in rat costal cartilage},
  url          = {http://dx.doi.org/10.3109/00016357209004594},
  volume       = {30},
  year         = {1972},
}