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Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes : A Meta-Analysis

González-Giraldo, Yeimy; Barreto, George E.; Fava, Cristiano LU and Forero, Diego A. (2016) In Journal of Stroke & Cerebrovascular Diseases
Abstract

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods: Literature search for 6 candidate polymorphisms and IS was conducted using HuGE Navigator, PubMed, and Google Scholar databases. Meta-Analyst program was used to calculate pooled odds ratios (ORs) with a random effects model. Results: Twenty-five published studies for 6 candidate polymorphisms were included: CRP-rs1800947 (5 studies), CRP-rs1205 (3... (More)

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods: Literature search for 6 candidate polymorphisms and IS was conducted using HuGE Navigator, PubMed, and Google Scholar databases. Meta-Analyst program was used to calculate pooled odds ratios (ORs) with a random effects model. Results: Twenty-five published studies for 6 candidate polymorphisms were included: CRP-rs1800947 (5 studies), CRP-rs1205 (3 studies), EPHX2-rs751141 (5 studies), FGA-rs6050 (6 studies), NOTCH3-rs3815188 (3 studies), and NOTCH3-rs1043994 (3 studies), for a total number of 7,825 IS cases and 56,532 control subjects. We did not find significant pooled ORs (P values > .05) for any of the genetic variants evaluated in this work. Conclusions: Our meta-analysis results did not show significant associations between these 6 polymorphisms in 4 candidate genes and IS, despite the functional role of some of these single nucleotide polymorphisms (e.g., rs6050 in FGA gene). Future studies are needed to identify additional main genetic risk factors for IS in different populations.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Candidate gene, Genetic factors, Ischemic stroke, Meta-analysis, Polymorphism, Risk factor
in
Journal of Stroke & Cerebrovascular Diseases
publisher
Elsevier
external identifiers
  • Scopus:84971671497
ISSN
1052-3057
DOI
10.1016/j.jstrokecerebrovasdis.2016.05.020
language
English
LU publication?
yes
id
b27dd0ae-dc05-4b72-a0dd-935d3a125ba6
date added to LUP
2016-07-05 10:55:58
date last changed
2016-10-19 16:12:54
@misc{b27dd0ae-dc05-4b72-a0dd-935d3a125ba6,
  abstract     = {<p>Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods: Literature search for 6 candidate polymorphisms and IS was conducted using HuGE Navigator, PubMed, and Google Scholar databases. Meta-Analyst program was used to calculate pooled odds ratios (ORs) with a random effects model. Results: Twenty-five published studies for 6 candidate polymorphisms were included: CRP-rs1800947 (5 studies), CRP-rs1205 (3 studies), EPHX2-rs751141 (5 studies), FGA-rs6050 (6 studies), NOTCH3-rs3815188 (3 studies), and NOTCH3-rs1043994 (3 studies), for a total number of 7,825 IS cases and 56,532 control subjects. We did not find significant pooled ORs (P values &gt; .05) for any of the genetic variants evaluated in this work. Conclusions: Our meta-analysis results did not show significant associations between these 6 polymorphisms in 4 candidate genes and IS, despite the functional role of some of these single nucleotide polymorphisms (e.g., rs6050 in FGA gene). Future studies are needed to identify additional main genetic risk factors for IS in different populations.</p>},
  author       = {González-Giraldo, Yeimy and Barreto, George E. and Fava, Cristiano and Forero, Diego A.},
  issn         = {1052-3057},
  keyword      = {Candidate gene,Genetic factors,Ischemic stroke,Meta-analysis,Polymorphism,Risk factor},
  language     = {eng},
  month        = {06},
  publisher    = {ARRAY(0xb693d60)},
  series       = {Journal of Stroke & Cerebrovascular Diseases},
  title        = {Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes : A Meta-Analysis},
  url          = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.05.020},
  year         = {2016},
}