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Monophasic action potentials : concepts to practical applications

Yuan, S LU ; Blomström-Lundqvist, C and Olsson, Bertil LU (1994) In Journal of Cardiovascular Electrophysiology 5(3). p.287-308
Abstract

Monophasic action potential (MAP) recordings reproduce the repolarization time course of intracellular action potentials with high accuracy and provide precise information on the local activation time. With the advantage of in vivo application and the development of the safer and simpler contact catheter technique, MAP recording has become the method of choice for evaluating myocardial repolarization changes. This review aims to provide information on practical application of MAP recording in the clinical setting. MAPs can easily be recorded from the endocardium with the contact catheter technique in the electrophysiology laboratory and from the epicardium with electrode probes during open heart surgery. The technical aspects are... (More)

Monophasic action potential (MAP) recordings reproduce the repolarization time course of intracellular action potentials with high accuracy and provide precise information on the local activation time. With the advantage of in vivo application and the development of the safer and simpler contact catheter technique, MAP recording has become the method of choice for evaluating myocardial repolarization changes. This review aims to provide information on practical application of MAP recording in the clinical setting. MAPs can easily be recorded from the endocardium with the contact catheter technique in the electrophysiology laboratory and from the epicardium with electrode probes during open heart surgery. The technical aspects are described in detail. The rate dependence of myocardial excitability and repolarization and the effect of antiarrhythmic drugs on MAP duration and effective refractory period are thoroughly reviewed. The use of MAPs in detecting myocardial ischemia, in studying early afterdepolarization and triggered arrhythmias, in measuring dispersion of repolarization, in identifying intracardiac conduction and the development of the T wave, and in verifying the arrhythmogenic effect of mechanoelectric feedback are presented. Computerized automatic analysis of MAPs and the limitations of the MAP technique are also discussed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Action Potentials, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Heart Diseases, Humans, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Journal of Cardiovascular Electrophysiology
volume
5
issue
3
pages
287 - 308
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0028220167
ISSN
1045-3873
DOI
10.1111/j.1540-8167.1994.tb01165.x
language
English
LU publication?
yes
id
b31cd0fa-1ecf-4802-9f57-0bbdc44a29dc
date added to LUP
2016-11-10 17:25:32
date last changed
2016-11-22 15:51:23
@misc{b31cd0fa-1ecf-4802-9f57-0bbdc44a29dc,
  abstract     = {<p>Monophasic action potential (MAP) recordings reproduce the repolarization time course of intracellular action potentials with high accuracy and provide precise information on the local activation time. With the advantage of in vivo application and the development of the safer and simpler contact catheter technique, MAP recording has become the method of choice for evaluating myocardial repolarization changes. This review aims to provide information on practical application of MAP recording in the clinical setting. MAPs can easily be recorded from the endocardium with the contact catheter technique in the electrophysiology laboratory and from the epicardium with electrode probes during open heart surgery. The technical aspects are described in detail. The rate dependence of myocardial excitability and repolarization and the effect of antiarrhythmic drugs on MAP duration and effective refractory period are thoroughly reviewed. The use of MAPs in detecting myocardial ischemia, in studying early afterdepolarization and triggered arrhythmias, in measuring dispersion of repolarization, in identifying intracardiac conduction and the development of the T wave, and in verifying the arrhythmogenic effect of mechanoelectric feedback are presented. Computerized automatic analysis of MAPs and the limitations of the MAP technique are also discussed.</p>},
  author       = {Yuan, S and Blomström-Lundqvist, C and Olsson, Bertil},
  issn         = {1045-3873},
  keyword      = {Action Potentials,Anti-Arrhythmia Agents,Arrhythmias, Cardiac,Heart Diseases,Humans,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {3},
  pages        = {287--308},
  publisher    = {ARRAY(0xa2bbbf0)},
  series       = {Journal of Cardiovascular Electrophysiology},
  title        = {Monophasic action potentials : concepts to practical applications},
  url          = {http://dx.doi.org/10.1111/j.1540-8167.1994.tb01165.x},
  volume       = {5},
  year         = {1994},
}