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Polymorphisms within base and nucleotide excision repair pathways and risk of differentiated thyroid carcinoma

Cipollini, Monica; Figlioli, Gisella; Maccari, Giuseppe; Garritano, Sonia; De Santi, Chiara; Melaiu, Ombretta; Barone, Elisa; Bambi, Franco; Ermini, Stefano and Pellegrini, Giovanni, et al. (2016) In DNA Repair 41. p.27-31
Abstract

The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and NER genes. For this purpose, the most strongly associated SNPs within NER and BER genes found in our previous GWAS on DTC were selected and replicated in an independent series of samples for a new case-control study. Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to... (More)

The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and NER genes. For this purpose, the most strongly associated SNPs within NER and BER genes found in our previous GWAS on DTC were selected and replicated in an independent series of samples for a new case-control study. Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, rs16962916 and rs3136166 in ERCC4, and rs17739370 and rs7689099 in NEIL3) was associated with the risk of DTC when the correction of multiple testing was applied. In conclusion, a role of NER and BER pathways was evoked in the susceptibility to DTC. However, this seemed to be limited to few polymorphic genes and the overall effect size appeared weak.

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@misc{b459be7d-0ccd-4224-9c84-42ff415c1f4a,
  abstract     = {<p>The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and NER genes. For this purpose, the most strongly associated SNPs within NER and BER genes found in our previous GWAS on DTC were selected and replicated in an independent series of samples for a new case-control study. Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, rs16962916 and rs3136166 in ERCC4, and rs17739370 and rs7689099 in NEIL3) was associated with the risk of DTC when the correction of multiple testing was applied. In conclusion, a role of NER and BER pathways was evoked in the susceptibility to DTC. However, this seemed to be limited to few polymorphic genes and the overall effect size appeared weak.</p>},
  author       = {Cipollini, Monica and Figlioli, Gisella and Maccari, Giuseppe and Garritano, Sonia and De Santi, Chiara and Melaiu, Ombretta and Barone, Elisa and Bambi, Franco and Ermini, Stefano and Pellegrini, Giovanni and Cristaudo, Alfonso and Foddis, Rudy and Bonotti, Alessandra and Romei, Cristina and Vivaldi, Agnese and Agate, Laura and Molinari, Eleonora and Barale, Roberto and Försti, Asta and Hemminki, Kari and Elisei, Rossella and Gemignani, Federica and Landi, Stefano},
  issn         = {1568-7864},
  keyword      = {BER,Differentiated thyroid cancer risk,NER,Polymorphism},
  language     = {eng},
  month        = {05},
  pages        = {27--31},
  publisher    = {ARRAY(0x8492d98)},
  series       = {DNA Repair},
  title        = {Polymorphisms within base and nucleotide excision repair pathways and risk of differentiated thyroid carcinoma},
  url          = {http://dx.doi.org/10.1016/j.dnarep.2016.03.011},
  volume       = {41},
  year         = {2016},
}