Decreased capillary density in juvenile dermatomyositis and in mixed connective tissue disease
(1999) In Journal of Rheumatology 26(6). p.81-1377- Abstract
OBJECTIVE: To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.
METHODS: Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.
RESULTS: Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p < 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p < 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8)... (More)
OBJECTIVE: To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.
METHODS: Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.
RESULTS: Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p < 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p < 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8) 10(-3) mm2 (p < 0.001)] and in MCTD [median 4.5 (3.0-6.0) 10(-3) mm2 (p < 0.02)] compared to controls [median 2.5 (1.0-4.0) 10(-3) mm2].
CONCLUSION: Quantitative nailfold capillary microscopy is a sensitive indicator of JDM. In MCTD this technique is less discriminative.
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- author
- Scheja, A LU ; Elborgh, R LU and Wildt, M LU
- organization
- publishing date
- 1999-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Age Factors, Capillaries, Child, Dermatomyositis, Female, Humans, Male, Mixed Connective Tissue Disease, Nails, Regional Blood Flow, Journal Article, Research Support, Non-U.S. Gov't
- in
- Journal of Rheumatology
- volume
- 26
- issue
- 6
- pages
- 5 pages
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- pmid:10381059
- scopus:0033042815
- ISSN
- 0315-162X
- language
- English
- LU publication?
- yes
- id
- b632e90c-b57d-40b3-b06a-0432900f3d04
- date added to LUP
- 2016-11-17 10:45:12
- date last changed
- 2024-04-05 10:28:53
@article{b632e90c-b57d-40b3-b06a-0432900f3d04, abstract = {{<p>OBJECTIVE: To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.</p><p>METHODS: Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.</p><p>RESULTS: Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p < 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p < 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8) 10(-3) mm2 (p < 0.001)] and in MCTD [median 4.5 (3.0-6.0) 10(-3) mm2 (p < 0.02)] compared to controls [median 2.5 (1.0-4.0) 10(-3) mm2].</p><p>CONCLUSION: Quantitative nailfold capillary microscopy is a sensitive indicator of JDM. In MCTD this technique is less discriminative.</p>}}, author = {{Scheja, A and Elborgh, R and Wildt, M}}, issn = {{0315-162X}}, keywords = {{Adolescent; Age Factors; Capillaries; Child; Dermatomyositis; Female; Humans; Male; Mixed Connective Tissue Disease; Nails; Regional Blood Flow; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{6}}, pages = {{81--1377}}, publisher = {{Journal of Rheumatology Publishing Company Limited}}, series = {{Journal of Rheumatology}}, title = {{Decreased capillary density in juvenile dermatomyositis and in mixed connective tissue disease}}, volume = {{26}}, year = {{1999}}, }