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Decreased capillary density in juvenile dermatomyositis and in mixed connective tissue disease

Scheja, A LU ; Elborgh, R LU and Wildt, M LU (1999) In Journal of Rheumatology 26(6). p.81-1377
Abstract

OBJECTIVE: To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.

METHODS: Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.

RESULTS: Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p < 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p < 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8)... (More)

OBJECTIVE: To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.

METHODS: Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.

RESULTS: Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p < 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p < 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8) 10(-3) mm2 (p < 0.001)] and in MCTD [median 4.5 (3.0-6.0) 10(-3) mm2 (p < 0.02)] compared to controls [median 2.5 (1.0-4.0) 10(-3) mm2].

CONCLUSION: Quantitative nailfold capillary microscopy is a sensitive indicator of JDM. In MCTD this technique is less discriminative.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Age Factors, Capillaries, Child, Dermatomyositis, Female, Humans, Male, Mixed Connective Tissue Disease, Nails, Regional Blood Flow, Journal Article, Research Support, Non-U.S. Gov't
in
Journal of Rheumatology
volume
26
issue
6
pages
5 pages
publisher
J Rheumatol Publ Co
external identifiers
  • Scopus:0033042815
ISSN
0315-162X
language
English
LU publication?
yes
id
b632e90c-b57d-40b3-b06a-0432900f3d04
date added to LUP
2016-11-17 10:45:12
date last changed
2016-11-29 14:48:12
@misc{b632e90c-b57d-40b3-b06a-0432900f3d04,
  abstract     = {<p>OBJECTIVE: To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.</p><p>METHODS: Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.</p><p>RESULTS: Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p &lt; 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p &lt; 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8) 10(-3) mm2 (p &lt; 0.001)] and in MCTD [median 4.5 (3.0-6.0) 10(-3) mm2 (p &lt; 0.02)] compared to controls [median 2.5 (1.0-4.0) 10(-3) mm2].</p><p>CONCLUSION: Quantitative nailfold capillary microscopy is a sensitive indicator of JDM. In MCTD this technique is less discriminative.</p>},
  author       = {Scheja, A and Elborgh, R and Wildt, M},
  issn         = {0315-162X},
  keyword      = {Adolescent,Age Factors,Capillaries,Child,Dermatomyositis,Female,Humans,Male,Mixed Connective Tissue Disease,Nails,Regional Blood Flow,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {6},
  pages        = {81--1377},
  publisher    = {ARRAY(0x7fdd338)},
  series       = {Journal of Rheumatology},
  title        = {Decreased capillary density in juvenile dermatomyositis and in mixed connective tissue disease},
  volume       = {26},
  year         = {1999},
}