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Simplifying microfluidic separation devices towards field-detection of blood parasites

Holm, S. H. LU ; Beech, J. P. LU ; Barrett, M. P. and Tegenfeldt, J. O. LU (2016) In Analytical Methods 8(16). p.3291-3300
Abstract

With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucially needed for rapid and accurate diagnosis. Here, we exemplify this in the application of blood parasite enrichment from a sample of blood. With trypanosomes as a model system we show a combination of functionalities designed into a single device based on several deterministic lateral displacement arrays of different depths arranged in series.... (More)

With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucially needed for rapid and accurate diagnosis. Here, we exemplify this in the application of blood parasite enrichment from a sample of blood. With trypanosomes as a model system we show a combination of functionalities designed into a single device based on several deterministic lateral displacement arrays of different depths arranged in series. With only one inlet and no expensive or complicated pumping mechanisms to run separations we ensure the level of simplicity necessary for field use.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Methods
volume
8
issue
16
pages
10 pages
publisher
Royal Society of Chemistry
external identifiers
  • Scopus:84969579625
ISSN
1759-9660
DOI
10.1039/c6ay00443a
language
English
LU publication?
yes
id
b79b88aa-c5a9-4876-af26-47431c6f8228
date added to LUP
2016-09-30 07:45:50
date last changed
2016-11-06 04:40:27
@misc{b79b88aa-c5a9-4876-af26-47431c6f8228,
  abstract     = {<p>With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucially needed for rapid and accurate diagnosis. Here, we exemplify this in the application of blood parasite enrichment from a sample of blood. With trypanosomes as a model system we show a combination of functionalities designed into a single device based on several deterministic lateral displacement arrays of different depths arranged in series. With only one inlet and no expensive or complicated pumping mechanisms to run separations we ensure the level of simplicity necessary for field use.</p>},
  author       = {Holm, S. H. and Beech, J. P. and Barrett, M. P. and Tegenfeldt, J. O.},
  issn         = {1759-9660},
  language     = {eng},
  month        = {04},
  number       = {16},
  pages        = {3291--3300},
  publisher    = {ARRAY(0x9d44648)},
  series       = {Analytical Methods},
  title        = {Simplifying microfluidic separation devices towards field-detection of blood parasites},
  url          = {http://dx.doi.org/10.1039/c6ay00443a},
  volume       = {8},
  year         = {2016},
}