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Antibodies to pneumococcal polysaccharides in human milk : lack of relationship to colonization and acute otitis media

Rosen, I Andersson; Håkansson, Anders P LU ; Aniansson, G LU ; Hansson, C; Andersson, B; Nylén, O; Sabharwal, H and Svanborg, C LU (1996) In Pediatric Infectious Disease Journal 15(6). p.498-507
Abstract

BACKGROUND: This study analyzed antibodies to pneumococcal polysaccharides in human milk and their effect on nasopharyngeal colonization and acute otitis media in breast-fed infants.

METHODS: A total of 503 milk samples were collected from 310 mothers. Nasopharyngeal cultures were obtained from their children at 2, 6 and 10 months postpartum, and the capsular groups/types of the Streptococcus pneumoniae isolates were determined.

RESULTS: Types 6A, 6B, 19A, 19F and 23F accounted for 54% of the pneumococcal isolates, but type 3 isolates were uncommon. Milk samples were analyzed for antibody activity to the common capsular polysaccharide types 6A, 19F and 23F; to the type 3 polysaccharide; to C-polysaccharide; and to... (More)

BACKGROUND: This study analyzed antibodies to pneumococcal polysaccharides in human milk and their effect on nasopharyngeal colonization and acute otitis media in breast-fed infants.

METHODS: A total of 503 milk samples were collected from 310 mothers. Nasopharyngeal cultures were obtained from their children at 2, 6 and 10 months postpartum, and the capsular groups/types of the Streptococcus pneumoniae isolates were determined.

RESULTS: Types 6A, 6B, 19A, 19F and 23F accounted for 54% of the pneumococcal isolates, but type 3 isolates were uncommon. Milk samples were analyzed for antibody activity to the common capsular polysaccharide types 6A, 19F and 23F; to the type 3 polysaccharide; to C-polysaccharide; and to phosphorylcholine (PC), a major component of the pneumococcal cell wall polysaccharide (CWPS). Anti-capsular antibody activity was low or absent in > 90% of the milk samples. In contrast anti-PC antibody activity was detected in 88% and anti-CWPS in 84% of the samples. The frequency of acute otitis media did not vary with the milk anti-capsular, anti-PC or anti-CWPS antibody activity.

CONCLUSIONS: There was no reduction in nasopharyngeal carriage of S. pneumoniae among children fed milk with anti-capsular or anti-PC antibody activity, but carriage was increased in those children who received milk with anti-CWPS antibody activity. A protective role of antipolysaccharide or anti-CWPS antibodies in milk was not detected under the study conditions.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Animals, Antibodies, Bacterial, Bacterial Capsules, Breast Feeding, Female, Humans, Infant, Infant, Newborn, Milk, Nasopharyngeal Diseases, Otitis Media, Phosphorylcholine, Polysaccharides, Bacterial, Streptococcus pneumoniae
in
Pediatric Infectious Disease Journal
volume
15
issue
6
pages
498 - 507
publisher
Lippincott Williams & Wilkins
external identifiers
  • Scopus:0006366581
ISSN
0891-3668
language
English
LU publication?
yes
id
bebec87e-4d47-412c-a575-988a5c3c4742
date added to LUP
2016-05-21 11:33:51
date last changed
2016-08-04 15:53:31
@misc{bebec87e-4d47-412c-a575-988a5c3c4742,
  abstract     = {<p>BACKGROUND: This study analyzed antibodies to pneumococcal polysaccharides in human milk and their effect on nasopharyngeal colonization and acute otitis media in breast-fed infants.</p><p>METHODS: A total of 503 milk samples were collected from 310 mothers. Nasopharyngeal cultures were obtained from their children at 2, 6 and 10 months postpartum, and the capsular groups/types of the Streptococcus pneumoniae isolates were determined.</p><p>RESULTS: Types 6A, 6B, 19A, 19F and 23F accounted for 54% of the pneumococcal isolates, but type 3 isolates were uncommon. Milk samples were analyzed for antibody activity to the common capsular polysaccharide types 6A, 19F and 23F; to the type 3 polysaccharide; to C-polysaccharide; and to phosphorylcholine (PC), a major component of the pneumococcal cell wall polysaccharide (CWPS). Anti-capsular antibody activity was low or absent in &gt; 90% of the milk samples. In contrast anti-PC antibody activity was detected in 88% and anti-CWPS in 84% of the samples. The frequency of acute otitis media did not vary with the milk anti-capsular, anti-PC or anti-CWPS antibody activity.</p><p>CONCLUSIONS: There was no reduction in nasopharyngeal carriage of S. pneumoniae among children fed milk with anti-capsular or anti-PC antibody activity, but carriage was increased in those children who received milk with anti-CWPS antibody activity. A protective role of antipolysaccharide or anti-CWPS antibodies in milk was not detected under the study conditions.</p>},
  author       = {Rosen, I Andersson and Håkansson, Anders P and Aniansson, G and Hansson, C and Andersson, B and Nylén, O and Sabharwal, H and Svanborg, C},
  issn         = {0891-3668},
  keyword      = {Adult,Animals,Antibodies, Bacterial,Bacterial Capsules,Breast Feeding,Female,Humans,Infant,Infant, Newborn,Milk,Nasopharyngeal Diseases,Otitis Media,Phosphorylcholine,Polysaccharides, Bacterial,Streptococcus pneumoniae},
  language     = {eng},
  number       = {6},
  pages        = {498--507},
  publisher    = {ARRAY(0x89267c8)},
  series       = {Pediatric Infectious Disease Journal},
  title        = {Antibodies to pneumococcal polysaccharides in human milk : lack of relationship to colonization and acute otitis media},
  volume       = {15},
  year         = {1996},
}