A National Swedish Twin-Sibling Study of Alcohol Use Disorders
(2016) In Twin Research and Human Genetics 19(5). p.430-437- Abstract
The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD. In this report, structural equation modeling in OpenMx was applied to (1) the three types of alcohol registration in a population-based sample of male–male twins and reared-together full and half siblings (total 208,810 pairs), and (2) AUD, as a single diagnosis, in male–male, female–female, and opposite-sex (OS) twins and reared-together full and half siblings (total 787,916 pairs). An independent pathway model... (More)
The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD. In this report, structural equation modeling in OpenMx was applied to (1) the three types of alcohol registration in a population-based sample of male–male twins and reared-together full and half siblings (total 208,810 pairs), and (2) AUD, as a single diagnosis, in male–male, female–female, and opposite-sex (OS) twins and reared-together full and half siblings (total 787,916 pairs). An independent pathway model fit best to the three forms of registration and indicated that between 70% and 92% of the genetic and 63% and 98% of the shared environmental effects were shared in common with the remainder unique to each form of AUD registration. Criminal registration had the largest proportion of unique genetic and environmental factors. The best fit model for AUD estimated the heritability to be 22% and 57%, respectively, in females and males. Both shared (12% vs. 6%) and special twin environment (29% vs. 2%) were substantially more important in females versus males. In conclusion, AUD ascertained from medical, pharmacy, and criminal Swedish registries largely share the same genetic and environmental risk factors. Large sex differences in the etiology of AUD were seen in this sample, with substantially stronger familial environmental and weaker genetic effects in females versus males.
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- author
- Kendler, Kenneth S. ; PirouziFard, MirNabi LU ; Lönn, Sara LU ; Edwards, Alexis C. ; Maes, Hermine H. LU ; Lichtenstein, Paul ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2016-08-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alcohol use disorder, registries, sex effects, siblings, twins
- in
- Twin Research and Human Genetics
- volume
- 19
- issue
- 5
- pages
- 8 pages
- publisher
- Cambridge University Press
- external identifiers
-
- scopus:84982146245
- pmid:27515133
- wos:000384428600004
- ISSN
- 1832-4274
- DOI
- 10.1017/thg.2016.62
- language
- English
- LU publication?
- yes
- id
- c301aef8-7833-4afe-9e6f-1aa44cf2e425
- date added to LUP
- 2016-09-20 13:30:31
- date last changed
- 2024-03-22 07:54:15
@article{c301aef8-7833-4afe-9e6f-1aa44cf2e425,
abstract = {{<p>The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD. In this report, structural equation modeling in OpenMx was applied to (1) the three types of alcohol registration in a population-based sample of male–male twins and reared-together full and half siblings (total 208,810 pairs), and (2) AUD, as a single diagnosis, in male–male, female–female, and opposite-sex (OS) twins and reared-together full and half siblings (total 787,916 pairs). An independent pathway model fit best to the three forms of registration and indicated that between 70% and 92% of the genetic and 63% and 98% of the shared environmental effects were shared in common with the remainder unique to each form of AUD registration. Criminal registration had the largest proportion of unique genetic and environmental factors. The best fit model for AUD estimated the heritability to be 22% and 57%, respectively, in females and males. Both shared (12% vs. 6%) and special twin environment (29% vs. 2%) were substantially more important in females versus males. In conclusion, AUD ascertained from medical, pharmacy, and criminal Swedish registries largely share the same genetic and environmental risk factors. Large sex differences in the etiology of AUD were seen in this sample, with substantially stronger familial environmental and weaker genetic effects in females versus males.</p>}},
author = {{Kendler, Kenneth S. and PirouziFard, MirNabi and Lönn, Sara and Edwards, Alexis C. and Maes, Hermine H. and Lichtenstein, Paul and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1832-4274}},
keywords = {{alcohol use disorder; registries; sex effects; siblings; twins}},
language = {{eng}},
month = {{08}},
number = {{5}},
pages = {{430--437}},
publisher = {{Cambridge University Press}},
series = {{Twin Research and Human Genetics}},
title = {{A National Swedish Twin-Sibling Study of Alcohol Use Disorders}},
url = {{http://dx.doi.org/10.1017/thg.2016.62}},
doi = {{10.1017/thg.2016.62}},
volume = {{19}},
year = {{2016}},
}