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A National Swedish Twin-Sibling Study of Alcohol Use Disorders

Kendler, Kenneth S.; PirouziFard, MirNabi LU ; Lönn, Sara LU ; Edwards, Alexis C.; Maes, Hermine H. LU ; Lichtenstein, Paul; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In Twin Research and Human Genetics p.1-8
Abstract

The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD. In this report, structural equation modeling in OpenMx was applied to (1) the three types of alcohol registration in a population-based sample of male–male twins and reared-together full and half siblings (total 208,810 pairs), and (2) AUD, as a single diagnosis, in male–male, female–female, and opposite-sex (OS) twins and reared-together full and half siblings (total 787,916 pairs). An independent pathway model... (More)

The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD. In this report, structural equation modeling in OpenMx was applied to (1) the three types of alcohol registration in a population-based sample of male–male twins and reared-together full and half siblings (total 208,810 pairs), and (2) AUD, as a single diagnosis, in male–male, female–female, and opposite-sex (OS) twins and reared-together full and half siblings (total 787,916 pairs). An independent pathway model fit best to the three forms of registration and indicated that between 70% and 92% of the genetic and 63% and 98% of the shared environmental effects were shared in common with the remainder unique to each form of AUD registration. Criminal registration had the largest proportion of unique genetic and environmental factors. The best fit model for AUD estimated the heritability to be 22% and 57%, respectively, in females and males. Both shared (12% vs. 6%) and special twin environment (29% vs. 2%) were substantially more important in females versus males. In conclusion, AUD ascertained from medical, pharmacy, and criminal Swedish registries largely share the same genetic and environmental risk factors. Large sex differences in the etiology of AUD were seen in this sample, with substantially stronger familial environmental and weaker genetic effects in females versus males.

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author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
alcohol use disorder, registries, sex effects, siblings, twins
in
Twin Research and Human Genetics
pages
8 pages
publisher
Australian Academic Press
external identifiers
  • Scopus:84982146245
ISSN
1832-4274
DOI
10.1017/thg.2016.62
language
English
LU publication?
yes
id
c301aef8-7833-4afe-9e6f-1aa44cf2e425
date added to LUP
2016-09-20 13:30:31
date last changed
2016-11-14 09:43:03
@misc{c301aef8-7833-4afe-9e6f-1aa44cf2e425,
  abstract     = {<p>The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD. In this report, structural equation modeling in OpenMx was applied to (1) the three types of alcohol registration in a population-based sample of male–male twins and reared-together full and half siblings (total 208,810 pairs), and (2) AUD, as a single diagnosis, in male–male, female–female, and opposite-sex (OS) twins and reared-together full and half siblings (total 787,916 pairs). An independent pathway model fit best to the three forms of registration and indicated that between 70% and 92% of the genetic and 63% and 98% of the shared environmental effects were shared in common with the remainder unique to each form of AUD registration. Criminal registration had the largest proportion of unique genetic and environmental factors. The best fit model for AUD estimated the heritability to be 22% and 57%, respectively, in females and males. Both shared (12% vs. 6%) and special twin environment (29% vs. 2%) were substantially more important in females versus males. In conclusion, AUD ascertained from medical, pharmacy, and criminal Swedish registries largely share the same genetic and environmental risk factors. Large sex differences in the etiology of AUD were seen in this sample, with substantially stronger familial environmental and weaker genetic effects in females versus males.</p>},
  author       = {Kendler, Kenneth S. and PirouziFard, MirNabi and Lönn, Sara and Edwards, Alexis C. and Maes, Hermine H. and Lichtenstein, Paul and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1832-4274},
  keyword      = {alcohol use disorder,registries,sex effects,siblings,twins},
  language     = {eng},
  month        = {08},
  pages        = {1--8},
  publisher    = {ARRAY(0x8cf40a0)},
  series       = {Twin Research and Human Genetics},
  title        = {A National Swedish Twin-Sibling Study of Alcohol Use Disorders},
  url          = {http://dx.doi.org/10.1017/thg.2016.62},
  year         = {2016},
}