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Acetophenone azine : A new allergen responsible for severe contact dermatitis from shin pads

Raison-Peyron, Nadia; Bergendorff, Ola LU ; Bourrain, Jean Luc and Bruze, Magnus LU (2016) In Contact Dermatitis 75(2). p.106-110
Abstract

Background: Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins. Objectives: To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player. Methods: High-performance liquid chromatography (HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads. Results: HPLC identified acetophenone azine at concentrations of approximately 20μg/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine... (More)

Background: Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins. Objectives: To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player. Methods: High-performance liquid chromatography (HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads. Results: HPLC identified acetophenone azine at concentrations of approximately 20μg/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine down to 0.001% in acetone, whereas acetophenone and hydrazine sulfate were both negative. Twenty controls were negative for acetophenone azine 0.01% in acetone. Conclusions: Acetophenone azine is a new, strong allergen of shin pads, and more generally of other sport equipment based on ethylene vinyl acetate. It may be used as a biocide, but this has to be confirmed. Further investigations are needed to understand factors such as exposure, cross-reaction patterns, metabolism, and the optimal patch test preparation.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acetophenone azine, Allergic contact dermatitis, CAS no. 729-43-1, Chemical analysis, EVA copolymers, Patch testing, Shin pads, Sport equipment
in
Contact Dermatitis
volume
75
issue
2
pages
106 - 110
publisher
Wiley-Blackwell
external identifiers
  • Scopus:84971323737
ISSN
0105-1873
DOI
10.1111/cod.12579
language
English
LU publication?
yes
id
c38bfc6a-c9d1-4269-9f1f-d8cb0d7ee23c
date added to LUP
2016-06-14 10:15:04
date last changed
2016-09-20 03:07:04
@misc{c38bfc6a-c9d1-4269-9f1f-d8cb0d7ee23c,
  abstract     = {<p>Background: Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins. Objectives: To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player. Methods: High-performance liquid chromatography (HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads. Results: HPLC identified acetophenone azine at concentrations of approximately 20μg/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine down to 0.001% in acetone, whereas acetophenone and hydrazine sulfate were both negative. Twenty controls were negative for acetophenone azine 0.01% in acetone. Conclusions: Acetophenone azine is a new, strong allergen of shin pads, and more generally of other sport equipment based on ethylene vinyl acetate. It may be used as a biocide, but this has to be confirmed. Further investigations are needed to understand factors such as exposure, cross-reaction patterns, metabolism, and the optimal patch test preparation.</p>},
  author       = {Raison-Peyron, Nadia and Bergendorff, Ola and Bourrain, Jean Luc and Bruze, Magnus},
  issn         = {0105-1873},
  keyword      = {Acetophenone azine,Allergic contact dermatitis,CAS no. 729-43-1,Chemical analysis,EVA copolymers,Patch testing,Shin pads,Sport equipment},
  language     = {eng},
  number       = {2},
  pages        = {106--110},
  publisher    = {ARRAY(0xb37f6d8)},
  series       = {Contact Dermatitis},
  title        = {Acetophenone azine : A new allergen responsible for severe contact dermatitis from shin pads},
  url          = {http://dx.doi.org/10.1111/cod.12579},
  volume       = {75},
  year         = {2016},
}