Acetophenone azine : A new allergen responsible for severe contact dermatitis from shin pads
(2016) In Contact Dermatitis 75(2). p.106-110- Abstract
Background: Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins. Objectives: To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player. Methods: High-performance liquid chromatography (HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads. Results: HPLC identified acetophenone azine at concentrations of approximately 20μg/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine... (More)
Background: Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins. Objectives: To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player. Methods: High-performance liquid chromatography (HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads. Results: HPLC identified acetophenone azine at concentrations of approximately 20μg/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine down to 0.001% in acetone, whereas acetophenone and hydrazine sulfate were both negative. Twenty controls were negative for acetophenone azine 0.01% in acetone. Conclusions: Acetophenone azine is a new, strong allergen of shin pads, and more generally of other sport equipment based on ethylene vinyl acetate. It may be used as a biocide, but this has to be confirmed. Further investigations are needed to understand factors such as exposure, cross-reaction patterns, metabolism, and the optimal patch test preparation.
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- author
- Raison-Peyron, Nadia ; Bergendorff, Ola LU ; Bourrain, Jean Luc and Bruze, Magnus LU
- organization
- publishing date
- 2016-05-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acetophenone azine, Allergic contact dermatitis, CAS no. 729-43-1, Chemical analysis, EVA copolymers, Patch testing, Shin pads, Sport equipment
- in
- Contact Dermatitis
- volume
- 75
- issue
- 2
- pages
- 106 - 110
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:27198908
- wos:000380901200006
- scopus:84977654737
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12579
- language
- English
- LU publication?
- yes
- id
- c38bfc6a-c9d1-4269-9f1f-d8cb0d7ee23c
- date added to LUP
- 2016-06-14 10:15:04
- date last changed
- 2022-09-07 18:55:17
@article{c38bfc6a-c9d1-4269-9f1f-d8cb0d7ee23c,
abstract = {{<p>Background: Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins. Objectives: To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player. Methods: High-performance liquid chromatography (HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads. Results: HPLC identified acetophenone azine at concentrations of approximately 20μg/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine down to 0.001% in acetone, whereas acetophenone and hydrazine sulfate were both negative. Twenty controls were negative for acetophenone azine 0.01% in acetone. Conclusions: Acetophenone azine is a new, strong allergen of shin pads, and more generally of other sport equipment based on ethylene vinyl acetate. It may be used as a biocide, but this has to be confirmed. Further investigations are needed to understand factors such as exposure, cross-reaction patterns, metabolism, and the optimal patch test preparation.</p>}},
author = {{Raison-Peyron, Nadia and Bergendorff, Ola and Bourrain, Jean Luc and Bruze, Magnus}},
issn = {{0105-1873}},
keywords = {{Acetophenone azine; Allergic contact dermatitis; CAS no. 729-43-1; Chemical analysis; EVA copolymers; Patch testing; Shin pads; Sport equipment}},
language = {{eng}},
month = {{05}},
number = {{2}},
pages = {{106--110}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Acetophenone azine : A new allergen responsible for severe contact dermatitis from shin pads}},
url = {{http://dx.doi.org/10.1111/cod.12579}},
doi = {{10.1111/cod.12579}},
volume = {{75}},
year = {{2016}},
}