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The aminoterminal-type-III procollagen pepetide and proteoglycans in serum and synovial fluid in patients with rheumatoid arthritis or reactive arthritis.

Hörslev-Pedersen, Kim; Saxne, Tore LU ; Haar, D; Thomsen, BS; Bentsen, KD; Junker, Peter and Lorenzen, Ib (1988) In Rheumatology International 8. p.1-9
Abstract
The concentrations of aminoterminal-type-III procollagen (procollagen N-) peptide, and of proteoglycans were measured in knee-joint synovial fluid and serum from patients with rheumatoid arthritis or reactive arthritis. All synovial fluids contained large amounts of intact propeptide. The synovial fluid: serum propeptide ratios were high, suggesting local propeptide liberation. A correlation was demonstrated between the propeptide concentration in synovial fluid and in serum. In rheumatoid arthritis, the propeptide concentration in synovial fluid was related to local inflammatory activity, and the serum concentration was correlated with the presence of nonspecific markers of inflammation. The presence of smaller propeptide fragments in... (More)
The concentrations of aminoterminal-type-III procollagen (procollagen N-) peptide, and of proteoglycans were measured in knee-joint synovial fluid and serum from patients with rheumatoid arthritis or reactive arthritis. All synovial fluids contained large amounts of intact propeptide. The synovial fluid: serum propeptide ratios were high, suggesting local propeptide liberation. A correlation was demonstrated between the propeptide concentration in synovial fluid and in serum. In rheumatoid arthritis, the propeptide concentration in synovial fluid was related to local inflammatory activity, and the serum concentration was correlated with the presence of nonspecific markers of inflammation. The presence of smaller propeptide fragments in synovial fluid indicated that some degradation occurred locally. The local metabolic changes were most prominent in patients with joint erosions. Patients with nonerosive rheumatoid arthritis and reactive arthritis had similar synovial fluid propeptide concentrations. The proteoglycan content of synovial fluid was inversely related to the degree of joint destruction, and was highest in patients with reactive arthritis. No correlation was observed between the concentrations of propeptide and proteoglycan in synovial fluid. Intraarticular glucocorticoid injection reduced the levels of propeptide and proteoglycan in synovial fluid (Less)
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Contribution to journal
publication status
published
subject
keywords
Arthritis, Rheumatoid/drug therapy, Proteoglycans/analysis, Prospective studies
in
Rheumatology International
volume
8
pages
1 - 9
publisher
Springer
ISSN
1437-160X
language
English
LU publication?
yes
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c739c9df-c101-4930-b882-3be04958d0ac
date added to LUP
2016-05-06 16:08:03
date last changed
2016-11-14 12:48:13
@misc{c739c9df-c101-4930-b882-3be04958d0ac,
  abstract     = {The concentrations of aminoterminal-type-III procollagen (procollagen N-) peptide, and of proteoglycans were measured in knee-joint synovial fluid and serum from patients with rheumatoid arthritis or reactive arthritis. All synovial fluids contained large amounts of intact propeptide. The synovial fluid: serum propeptide ratios were high, suggesting local propeptide liberation. A correlation was demonstrated between the propeptide concentration in synovial fluid and in serum. In rheumatoid arthritis, the propeptide concentration in synovial fluid was related to local inflammatory activity, and the serum concentration was correlated with the presence of nonspecific markers of inflammation. The presence of smaller propeptide fragments in synovial fluid indicated that some degradation occurred locally. The local metabolic changes were most prominent in patients with joint erosions. Patients with nonerosive rheumatoid arthritis and reactive arthritis had similar synovial fluid propeptide concentrations. The proteoglycan content of synovial fluid was inversely related to the degree of joint destruction, and was highest in patients with reactive arthritis. No correlation was observed between the concentrations of propeptide and proteoglycan in synovial fluid. Intraarticular glucocorticoid injection reduced the levels of propeptide and proteoglycan in synovial fluid},
  author       = {Hörslev-Pedersen, Kim and Saxne, Tore and Haar, D and Thomsen, BS and Bentsen, KD and Junker, Peter and Lorenzen, Ib},
  issn         = {1437-160X},
  keyword      = {Arthritis, Rheumatoid/drug therapy,Proteoglycans/analysis,Prospective studies},
  language     = {eng},
  pages        = {1--9},
  publisher    = {ARRAY(0x9631170)},
  series       = {Rheumatology International},
  title        = {The aminoterminal-type-III procollagen pepetide and proteoglycans in serum and synovial fluid in patients with rheumatoid arthritis or reactive arthritis.},
  volume       = {8},
  year         = {1988},
}