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Structural biology of starch-degrading enzymes and their regulation

Møller, Marie Sofie LU and Svensson, Birte (2016) In Current Opinion in Structural Biology 40. p.33-42
Abstract

Starch is a major energy source for all domains of life. Recent advances in structures of starch-degrading enzymes encompass the substrate complex of starch debranching enzyme, the function of surface binding sites in plant isoamylase, details on individual steps in the mechanism of plant disproportionating enzyme and a self-stabilised conformation of amylose accommodated in the active site of plant α-glucosidase. Important inhibitor complexes include a flavonol glycoside, montbretin A, binding at the active site of human pancreatic α-amylase and barley limit dextrinase inhibitor binding to the debranching enzyme, limit dextrinase using a new binding mode for cereal protein inhibitors.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Structural Biology
volume
40
pages
10 pages
publisher
Elsevier
external identifiers
  • Scopus:84979695897
ISSN
0959-440X
DOI
10.1016/j.sbi.2016.07.006
language
English
LU publication?
yes
id
cdb4f61e-5352-48e0-9ed8-873c9416b4a1
date added to LUP
2016-10-17 10:37:23
date last changed
2016-10-18 03:00:04
@misc{cdb4f61e-5352-48e0-9ed8-873c9416b4a1,
  abstract     = {<p>Starch is a major energy source for all domains of life. Recent advances in structures of starch-degrading enzymes encompass the substrate complex of starch debranching enzyme, the function of surface binding sites in plant isoamylase, details on individual steps in the mechanism of plant disproportionating enzyme and a self-stabilised conformation of amylose accommodated in the active site of plant α-glucosidase. Important inhibitor complexes include a flavonol glycoside, montbretin A, binding at the active site of human pancreatic α-amylase and barley limit dextrinase inhibitor binding to the debranching enzyme, limit dextrinase using a new binding mode for cereal protein inhibitors.</p>},
  author       = {Møller, Marie Sofie and Svensson, Birte},
  issn         = {0959-440X},
  language     = {eng},
  month        = {10},
  pages        = {33--42},
  publisher    = {ARRAY(0x82dd218)},
  series       = {Current Opinion in Structural Biology},
  title        = {Structural biology of starch-degrading enzymes and their regulation},
  url          = {http://dx.doi.org/10.1016/j.sbi.2016.07.006},
  volume       = {40},
  year         = {2016},
}