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Safety of pancreatic resection in the elderly : a retrospective analysis of 556 patients

Ansari, Daniel LU ; Aronsson, Linus LU ; Fredriksson, Joakim; Andersson, Bodil LU and Andersson, Roland LU (2016) In Annals of Gastroenterology 29(2). p.5-221
Abstract

BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.

METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged <75 and ≥75 years.

RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups.... (More)

BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.

METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged <75 and ≥75 years.

RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups. The incidence of postoperative pancreatic fistula grade A was significantly lower in the elderly group (P=0.022), but no significant differences were noted in the overall morbidity or the incidence of postpancreatectomy hemorrhage, delayed gastric emptying, bile leakage, cardiac complications, pulmonary complications or septic complications. The 30-day mortality rate was similar between groups (0.8% vs. 1.3%; P=0.532).

CONCLUSION: Pancreatic resection is a safe option for selected elderly patients. Our study confirms that age alone should not preclude potentially curative surgical therapy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Gastroenterology
volume
29
issue
2
pages
5 pages
publisher
Hellenic Society of Gastroenterology
external identifiers
  • Scopus:84962366074
ISSN
1108-7471
DOI
10.20524/aog.2016.0016
language
English
LU publication?
yes
id
cea5c9ef-a995-47be-8928-c530bc06aba6
date added to LUP
2016-05-04 08:44:41
date last changed
2016-10-13 05:07:33
@misc{cea5c9ef-a995-47be-8928-c530bc06aba6,
  abstract     = {<p>BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.</p><p>METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged &lt;75 and ≥75 years.</p><p>RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups. The incidence of postoperative pancreatic fistula grade A was significantly lower in the elderly group (P=0.022), but no significant differences were noted in the overall morbidity or the incidence of postpancreatectomy hemorrhage, delayed gastric emptying, bile leakage, cardiac complications, pulmonary complications or septic complications. The 30-day mortality rate was similar between groups (0.8% vs. 1.3%; P=0.532).</p><p>CONCLUSION: Pancreatic resection is a safe option for selected elderly patients. Our study confirms that age alone should not preclude potentially curative surgical therapy.</p>},
  author       = {Ansari, Daniel and Aronsson, Linus and Fredriksson, Joakim and Andersson, Bodil and Andersson, Roland},
  issn         = {1108-7471},
  language     = {eng},
  number       = {2},
  pages        = {5--221},
  publisher    = {ARRAY(0x9768090)},
  series       = {Annals of Gastroenterology},
  title        = {Safety of pancreatic resection in the elderly : a retrospective analysis of 556 patients},
  url          = {http://dx.doi.org/10.20524/aog.2016.0016},
  volume       = {29},
  year         = {2016},
}