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Species diversity regarding the presence of proximal tubular progenitor cells of the kidney

Hansson, J LU ; Ericsson, A E; Axelson, Håkan LU and Johansson, Martin LU (2016) In European Journal of Histochemistry 60(1). p.2567-2567
Abstract

The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting... (More)

The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Histochemistry
volume
60
issue
1
pages
2567 - 2567
publisher
SOCIETA ITALIANA DI ISTOCHIMICA
external identifiers
  • Scopus:84958539725
ISSN
2038-8306
DOI
10.4081/ejh.2016.2567
language
English
LU publication?
yes
id
cf3a16f8-298e-4527-be86-5196de28142d
date added to LUP
2016-04-11 14:24:08
date last changed
2016-10-13 05:05:54
@misc{cf3a16f8-298e-4527-be86-5196de28142d,
  abstract     = {<p>The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.</p>},
  author       = {Hansson, J and Ericsson, A E and Axelson, Håkan and Johansson, Martin},
  issn         = {2038-8306},
  language     = {eng},
  number       = {1},
  pages        = {2567--2567},
  publisher    = {ARRAY(0x94af680)},
  series       = {European Journal of Histochemistry},
  title        = {Species diversity regarding the presence of proximal tubular progenitor cells of the kidney},
  url          = {http://dx.doi.org/10.4081/ejh.2016.2567},
  volume       = {60},
  year         = {2016},
}