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Polyamine metabolism in rat parotid gland after duct ligation

Nilsson, Bengt-Olof LU (1987) In Acta Physiol.Scand 131(2). p.177-81
Abstract

Parotid ducts were ligated unilaterally in rats for periods from 6 h to 5 months. A slight increase in gland weight was observed during the first 24 h; thereafter, the weight gradually fell, being less than 50% of controls at 5 months. The activity of the putrescine-forming enzyme, ornithine decarboxylase (ODC), increased with peak values by 3 days and 3 weeks. However, the putrescine content had already reached its highest value by 24 h. A notably marked reduction of spermidine and spermine contents was observed by 1 day after ligation and throughout the whole time of observation. The results suggest that an inverse polyamine metabolism occurred, that is, spermine converts to spermidine which in turn converts to putrescine.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Ligation, Male, Organ Size, Ornithine Decarboxylase, Parotid Gland, Putrescine, Rats, Rats, Inbred Strains, Spermidine, Spermine
in
Acta Physiol.Scand
volume
131
issue
2
pages
5 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0023552906
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1987.tb08224.x
language
English
LU publication?
yes
id
d263e4a1-c2ef-4b45-aa07-325948b7f1fe
date added to LUP
2016-06-17 16:51:43
date last changed
2016-07-04 11:55:39
@misc{d263e4a1-c2ef-4b45-aa07-325948b7f1fe,
  abstract     = {<p>Parotid ducts were ligated unilaterally in rats for periods from 6 h to 5 months. A slight increase in gland weight was observed during the first 24 h; thereafter, the weight gradually fell, being less than 50% of controls at 5 months. The activity of the putrescine-forming enzyme, ornithine decarboxylase (ODC), increased with peak values by 3 days and 3 weeks. However, the putrescine content had already reached its highest value by 24 h. A notably marked reduction of spermidine and spermine contents was observed by 1 day after ligation and throughout the whole time of observation. The results suggest that an inverse polyamine metabolism occurred, that is, spermine converts to spermidine which in turn converts to putrescine.</p>},
  author       = {Nilsson, Bengt-Olof},
  issn         = {0001-6772},
  keyword      = {Animals,Ligation,Male,Organ Size,Ornithine Decarboxylase,Parotid Gland,Putrescine,Rats,Rats, Inbred Strains,Spermidine,Spermine},
  language     = {eng},
  number       = {2},
  pages        = {177--81},
  publisher    = {ARRAY(0x841e648)},
  series       = {Acta Physiol.Scand},
  title        = {Polyamine metabolism in rat parotid gland after duct ligation},
  url          = {http://dx.doi.org/10.1111/j.1748-1716.1987.tb08224.x},
  volume       = {131},
  year         = {1987},
}