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A long-term longitudinal follow-up of depressed patients treated with ECT with special focus on development of dementia

Berggren, Åke; Gustafson, Lars LU ; Höglund, Peter LU and Johanson, Aki LU (2016) In Journal of Affective Disorders 200. p.15-24
Abstract

Background In this study, the long term effects of ECT on patients with depression were investigated through repeated rCBF and EEG measures as well as clinical characteristics over several years. The aim of the investigation was to establish an association with the eventual development of dementia. Method A cohort of forty-nine patients (21 men and 28 women) with a mean age of 61 years underwent ECT. A subsequent evaluation from medical records and three rating-scales for diagnosis of Alzheimeŕs disease (AD), fronto-temporal dementia (FTD), and for vascular dementia (VaD), revealed that 17 patients (8 men and 9 women), had developed dementia. These cases were compared to the 32 patients (13 men and 19 women), who had not developed... (More)

Background In this study, the long term effects of ECT on patients with depression were investigated through repeated rCBF and EEG measures as well as clinical characteristics over several years. The aim of the investigation was to establish an association with the eventual development of dementia. Method A cohort of forty-nine patients (21 men and 28 women) with a mean age of 61 years underwent ECT. A subsequent evaluation from medical records and three rating-scales for diagnosis of Alzheimeŕs disease (AD), fronto-temporal dementia (FTD), and for vascular dementia (VaD), revealed that 17 patients (8 men and 9 women), had developed dementia. These cases were compared to the 32 patients (13 men and 19 women), who had not developed dementia. Result Initially, the dementia group, compared to those without dementia, showed a lower hemispheric CBF (left side; p=.029, right side; p=.033), and a lower mean occipital EEG frequency (p=.048). After the first ECT-series, an increase in general disorientation (p=.015), personal disorientation (p=.009), and subsequently, spatial disorientation (p=.021), were seen in the dementia group. There were no differences in the clinical response or remissions after treatment in the groups. Limitations The small sample-size, which did not allow for the comparison of characteristics between different dementias. Conclusion Depressed older patients who later developed dementia showed lower hemispheric mean level of CBF and EEG mean frequency before ECT and higher personal and spatial disorientation following ECT.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Clinical characteristics, Dementia, EEG, Electroconvulsive therapy, Major depression, RCBF
in
Journal of Affective Disorders
volume
200
pages
10 pages
publisher
Elsevier
external identifiers
  • Scopus:84964533506
ISSN
0165-0327
DOI
10.1016/j.jad.2016.04.004
language
English
LU publication?
yes
id
d3245b3e-0b58-4a22-9427-40748ab1661c
date added to LUP
2016-05-31 12:12:50
date last changed
2016-09-27 15:28:31
@misc{d3245b3e-0b58-4a22-9427-40748ab1661c,
  abstract     = {<p>Background In this study, the long term effects of ECT on patients with depression were investigated through repeated rCBF and EEG measures as well as clinical characteristics over several years. The aim of the investigation was to establish an association with the eventual development of dementia. Method A cohort of forty-nine patients (21 men and 28 women) with a mean age of 61 years underwent ECT. A subsequent evaluation from medical records and three rating-scales for diagnosis of Alzheimeŕs disease (AD), fronto-temporal dementia (FTD), and for vascular dementia (VaD), revealed that 17 patients (8 men and 9 women), had developed dementia. These cases were compared to the 32 patients (13 men and 19 women), who had not developed dementia. Result Initially, the dementia group, compared to those without dementia, showed a lower hemispheric CBF (left side; p=.029, right side; p=.033), and a lower mean occipital EEG frequency (p=.048). After the first ECT-series, an increase in general disorientation (p=.015), personal disorientation (p=.009), and subsequently, spatial disorientation (p=.021), were seen in the dementia group. There were no differences in the clinical response or remissions after treatment in the groups. Limitations The small sample-size, which did not allow for the comparison of characteristics between different dementias. Conclusion Depressed older patients who later developed dementia showed lower hemispheric mean level of CBF and EEG mean frequency before ECT and higher personal and spatial disorientation following ECT.</p>},
  author       = {Berggren, Åke and Gustafson, Lars and Höglund, Peter and Johanson, Aki},
  issn         = {0165-0327},
  keyword      = {Clinical characteristics,Dementia,EEG,Electroconvulsive therapy,Major depression,RCBF},
  language     = {eng},
  month        = {08},
  pages        = {15--24},
  publisher    = {ARRAY(0xb6303e8)},
  series       = {Journal of Affective Disorders},
  title        = {A long-term longitudinal follow-up of depressed patients treated with ECT with special focus on development of dementia},
  url          = {http://dx.doi.org/10.1016/j.jad.2016.04.004},
  volume       = {200},
  year         = {2016},
}