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Spermidine/spermine-N1-acetyltransferase activity in isoprenaline-stimulated rat salivary glands

Ekström, J.; Månsson, Bengt LU ; Nilsson, B O LU ; Rosengren, Elsa and Tobin, G (1989) In Acta Physiol.Scand 135(3). p.54-249
Abstract

In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine... (More)

In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine markedly. The result obtained in this gland indicates interconversion of higher polyamines to putrescine.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Acetyltransferases, Animals, Infusions, Intravenous, Isoproterenol, Male, Organ Size, Ornithine Decarboxylase, Putrescine, Rats, Rats, Inbred Strains, Salivary Glands, Spermidine, Spermine
in
Acta Physiol.Scand
volume
135
issue
3
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0024477714
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1989.tb08574.x
language
English
LU publication?
yes
id
d8303fc6-8afe-4377-aded-5863fbd4e315
date added to LUP
2016-06-17 16:51:05
date last changed
2016-12-04 04:52:20
@misc{d8303fc6-8afe-4377-aded-5863fbd4e315,
  abstract     = {<p>In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine markedly. The result obtained in this gland indicates interconversion of higher polyamines to putrescine.</p>},
  author       = {Ekström, J. and Månsson, Bengt and Nilsson, B O and Rosengren, Elsa and Tobin, G},
  issn         = {0001-6772},
  keyword      = {Acetyltransferases,Animals,Infusions, Intravenous,Isoproterenol,Male,Organ Size,Ornithine Decarboxylase,Putrescine,Rats,Rats, Inbred Strains,Salivary Glands,Spermidine,Spermine},
  language     = {eng},
  number       = {3},
  pages        = {54--249},
  publisher    = {ARRAY(0x8244e30)},
  series       = {Acta Physiol.Scand},
  title        = {Spermidine/spermine-N1-acetyltransferase activity in isoprenaline-stimulated rat salivary glands},
  url          = {http://dx.doi.org/10.1111/j.1748-1716.1989.tb08574.x},
  volume       = {135},
  year         = {1989},
}