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Transient synovitis of the hip in the child : Increased levels of proteoglycan fragments in joint fluid

Lohmander, Stefan LU ; Wingstrand, H. LU and Heinegard, D. (1988) In Journal of Orthopaedic Research 6(3). p.420-424
Abstract

The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability... (More)

The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelae of these diseases.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
child, hip, Transient synovitis
in
Journal of Orthopaedic Research
volume
6
issue
3
pages
5 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0023944153
ISSN
0736-0266
language
English
LU publication?
yes
id
da53c0fb-b259-4e7a-ab5c-cf97d2f40033
date added to LUP
2016-05-04 13:09:33
date last changed
2016-05-24 11:53:36
@misc{da53c0fb-b259-4e7a-ab5c-cf97d2f40033,
  abstract     = {<p>The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelae of these diseases.</p>},
  author       = {Lohmander, Stefan and Wingstrand, H. and Heinegard, D.},
  issn         = {0736-0266},
  keyword      = {child,hip,Transient synovitis},
  language     = {eng},
  number       = {3},
  pages        = {420--424},
  publisher    = {ARRAY(0xa1de420)},
  series       = {Journal of Orthopaedic Research},
  title        = {Transient synovitis of the hip in the child : Increased levels of proteoglycan fragments in joint fluid},
  volume       = {6},
  year         = {1988},
}