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Shared genetic factors involved in celiac disease, type 2 diabetes and anorexia nervosa suggest common molecular pathways for chronic diseases

Mostowy, Joanna; Montén, Caroline LU ; Gudjonsdottir, Audur H.; Arnell, Henrik; Browaldh, Lars; Nilsson, Staffan; Agardh, Daniel LU and Naluai, Åsa Torinsson (2016) In PLoS One 11(8).
Abstract

Background and Objectives: Genome-wide association studies (GWAS) have identified several genetic regions involved in immune-regulatory mechanisms to be associated with celiac disease. Previous GWAS also revealed an over-representation of genes involved in type 2 diabetes and anorexia nervosa associated with celiac disease, suggesting involvement of common metabolic pathways for development of these chronic diseases. The aim of this study was to extend these previous analyses to study the gene expression in the gut from children with active celiac disease. Material and Methods: Thirty six target genes involved in type 2 diabetes and four genes associated with anorexia nervosa were investigated for gene expression in small intestinal... (More)

Background and Objectives: Genome-wide association studies (GWAS) have identified several genetic regions involved in immune-regulatory mechanisms to be associated with celiac disease. Previous GWAS also revealed an over-representation of genes involved in type 2 diabetes and anorexia nervosa associated with celiac disease, suggesting involvement of common metabolic pathways for development of these chronic diseases. The aim of this study was to extend these previous analyses to study the gene expression in the gut from children with active celiac disease. Material and Methods: Thirty six target genes involved in type 2 diabetes and four genes associated with anorexia nervosa were investigated for gene expression in small intestinal biopsies from 144 children with celiac disease at median (range) age of 7.4 years (1.6-17.8) and from 154 disease controls at a median (range) age 11.4.years (1.4-18.3). Results: A total of eleven of genes were differently expressed in celiac patients compared with disease controls of which CD36, CD38, FOXP1, SELL, PPARA, PPARG, AGT previously associated with type 2 diabetes and AKAP6, NTNG1 with anorexia nervosa remained significant after correction for multiple testing. Conclusion: Shared genetic factors involved in celiac disease, type 2 diabetes and anorexia nervosa suggest common underlying molecular pathways for these diseases.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS One
volume
11
issue
8
publisher
Public Library of Science
external identifiers
  • Scopus:84983086816
ISSN
1932-6203
DOI
10.1371/journal.pone.0159593
language
English
LU publication?
yes
id
dae9c89f-5505-4b7e-861e-e4509faa3243
date added to LUP
2016-09-20 16:59:26
date last changed
2016-11-14 09:43:04
@misc{dae9c89f-5505-4b7e-861e-e4509faa3243,
  abstract     = {<p>Background and Objectives: Genome-wide association studies (GWAS) have identified several genetic regions involved in immune-regulatory mechanisms to be associated with celiac disease. Previous GWAS also revealed an over-representation of genes involved in type 2 diabetes and anorexia nervosa associated with celiac disease, suggesting involvement of common metabolic pathways for development of these chronic diseases. The aim of this study was to extend these previous analyses to study the gene expression in the gut from children with active celiac disease. Material and Methods: Thirty six target genes involved in type 2 diabetes and four genes associated with anorexia nervosa were investigated for gene expression in small intestinal biopsies from 144 children with celiac disease at median (range) age of 7.4 years (1.6-17.8) and from 154 disease controls at a median (range) age 11.4.years (1.4-18.3). Results: A total of eleven of genes were differently expressed in celiac patients compared with disease controls of which CD36, CD38, FOXP1, SELL, PPARA, PPARG, AGT previously associated with type 2 diabetes and AKAP6, NTNG1 with anorexia nervosa remained significant after correction for multiple testing. Conclusion: Shared genetic factors involved in celiac disease, type 2 diabetes and anorexia nervosa suggest common underlying molecular pathways for these diseases.</p>},
  author       = {Mostowy, Joanna and Montén, Caroline and Gudjonsdottir, Audur H. and Arnell, Henrik and Browaldh, Lars and Nilsson, Staffan and Agardh, Daniel and Naluai, Åsa Torinsson},
  issn         = {1932-6203},
  language     = {eng},
  month        = {08},
  number       = {8},
  publisher    = {ARRAY(0x93d5cf0)},
  series       = {PLoS One},
  title        = {Shared genetic factors involved in celiac disease, type 2 diabetes and anorexia nervosa suggest common molecular pathways for chronic diseases},
  url          = {http://dx.doi.org/10.1371/journal.pone.0159593},
  volume       = {11},
  year         = {2016},
}