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Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise.

Roos, Harald LU ; Dahlberg, Leif LU ; Hoerrner, Lori A.; Lark, Michael W.; Thonar, Eugene J M A; Shinmei, Masayuki; Lindqvist, Ulla and Stefan Lohmander, L. LU (1995) In Osteoarthritis and Cartilage 3(1). p.14-7
Abstract

The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the samples after exercise were obtained 30-60 min after the exercise. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). A reference group of 28 patients with knee pain but not evidence of joint pathology or injury was used for comparison. In joint fluid no single marker from the degradative... (More)

The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the samples after exercise were obtained 30-60 min after the exercise. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). A reference group of 28 patients with knee pain but not evidence of joint pathology or injury was used for comparison. In joint fluid no single marker from the degradative processes in cartilage matrix changed significantly with exercise but all showed a rising trend. All markers except stromelysin showed lower concentrations in athletes at rest compared to the reference group. In serum from runners before exercise the concentration of keratan sulfate was significantly higher than in both the soccer and reference groups and further increased after exercise. The increase in markers after exercise may reflect an effect of mechanical loading in combination with a possible high turnover rate of body cartilage matrix in these individuals. © 1995 Osteoarthritis Research Society.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cartilage, Exercise, Joint fluid, Knee joint, Markers, Serum
in
Osteoarthritis and Cartilage
volume
3
issue
1
pages
8 pages
publisher
Elsevier
external identifiers
  • Scopus:0028951758
ISSN
1063-4584
DOI
10.1016/S1063-4584(05)80033-0
language
English
LU publication?
yes
id
dcbd1b21-b2ce-4559-aa18-f357243a078c
date added to LUP
2016-05-04 23:48:17
date last changed
2016-06-13 11:27:57
@misc{dcbd1b21-b2ce-4559-aa18-f357243a078c,
  abstract     = {<p>The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the samples after exercise were obtained 30-60 min after the exercise. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). A reference group of 28 patients with knee pain but not evidence of joint pathology or injury was used for comparison. In joint fluid no single marker from the degradative processes in cartilage matrix changed significantly with exercise but all showed a rising trend. All markers except stromelysin showed lower concentrations in athletes at rest compared to the reference group. In serum from runners before exercise the concentration of keratan sulfate was significantly higher than in both the soccer and reference groups and further increased after exercise. The increase in markers after exercise may reflect an effect of mechanical loading in combination with a possible high turnover rate of body cartilage matrix in these individuals. © 1995 Osteoarthritis Research Society.</p>},
  author       = {Roos, Harald and Dahlberg, Leif and Hoerrner, Lori A. and Lark, Michael W. and Thonar, Eugene J M A and Shinmei, Masayuki and Lindqvist, Ulla and Stefan Lohmander, L.},
  issn         = {1063-4584},
  keyword      = {Cartilage,Exercise,Joint fluid,Knee joint,Markers,Serum},
  language     = {eng},
  number       = {1},
  pages        = {14--7},
  publisher    = {ARRAY(0x7f221f8)},
  series       = {Osteoarthritis and Cartilage},
  title        = {Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise.},
  url          = {http://dx.doi.org/10.1016/S1063-4584(05)80033-0},
  volume       = {3},
  year         = {1995},
}