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Design of a molecular clock with RNA-mediated regulation

Blanchini, Franco ; Cuba Samaniego, Christian ; Franco, Elisa and Giordano, Giulia LU (2014) 2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014 p.4611-4616
Abstract

We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the IEEE Conference on Decision and Control
article number
7040109
pages
6 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014
conference location
Los Angeles, United States
conference dates
2014-12-15 - 2014-12-17
external identifiers
  • scopus:84992254999
DOI
10.1109/CDC.2014.7040109
language
English
LU publication?
no
id
ddb91431-8be3-4998-8a5b-e24fba5c125e
date added to LUP
2016-07-06 15:21:40
date last changed
2022-05-02 04:21:03
@inproceedings{ddb91431-8be3-4998-8a5b-e24fba5c125e,
  abstract     = {{<p>We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.</p>}},
  author       = {{Blanchini, Franco and Cuba Samaniego, Christian and Franco, Elisa and Giordano, Giulia}},
  booktitle    = {{Proceedings of the IEEE Conference on Decision and Control}},
  language     = {{eng}},
  pages        = {{4611--4616}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  title        = {{Design of a molecular clock with RNA-mediated regulation}},
  url          = {{http://dx.doi.org/10.1109/CDC.2014.7040109}},
  doi          = {{10.1109/CDC.2014.7040109}},
  year         = {{2014}},
}