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Design of a molecular clock with RNA-mediated regulation

Blanchini, Franco; Cuba Samaniego, Christian; Franco, Elisa and Giordano, Giulia LU (2014) 2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014 In Proceedings of the IEEE Conference on Decision and Control p.4611-4616
Abstract

We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.

Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Proceedings of the IEEE Conference on Decision and Control
pages
6 pages
publisher
Institute of Electrical and Electronics Engineers Inc.
conference name
2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014
external identifiers
  • Scopus:84931858517
DOI
10.1109/CDC.2014.7040109
language
English
LU publication?
no
id
ddb91431-8be3-4998-8a5b-e24fba5c125e
date added to LUP
2016-07-06 15:21:40
date last changed
2016-11-29 11:30:47
@misc{ddb91431-8be3-4998-8a5b-e24fba5c125e,
  abstract     = {<p>We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.</p>},
  author       = {Blanchini, Franco and Cuba Samaniego, Christian and Franco, Elisa and Giordano, Giulia},
  language     = {eng},
  pages        = {4611--4616},
  publisher    = {ARRAY(0x89f9f10)},
  series       = {Proceedings of the IEEE Conference on Decision and Control},
  title        = {Design of a molecular clock with RNA-mediated regulation},
  url          = {http://dx.doi.org/10.1109/CDC.2014.7040109},
  year         = {2014},
}