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Candida albicans arthritis in a nonimmuno-compromised patient : Complication of placebo intraarticular injections

Christensson, Bertil LU ; Ryd, Leif LU ; Dahlberg, Leif LU and Lohmander, Stefan LU (1993) In Acta Orthopaedica 64(6). p.695-698
Abstract

A nonimmunocompromised 32-year-old man with arthrosis of the knee participated as a placebo control in a clinical trial of intraarticular injections of hya-luronan. After the fourth weekly injection of saline, he developed a warm and swollen knee, and synovia! fluid cultures revealed growth of Candida albicans. Oral fluconazole treatment was instituted 2 weeks after onset of symptoms, but failed to eradicate the infection. the patient recovered after treatment with local and systemic amphotericin B, systemic 5-fluo-rocytosine and surgical synovectomy. Quantitation of joint cartilage proteoglycan fragments in synovia! fluid indicated extensive breakdown of cartilage during the acute phase of arthritis but, parallel to clinical recovery,... (More)

A nonimmunocompromised 32-year-old man with arthrosis of the knee participated as a placebo control in a clinical trial of intraarticular injections of hya-luronan. After the fourth weekly injection of saline, he developed a warm and swollen knee, and synovia! fluid cultures revealed growth of Candida albicans. Oral fluconazole treatment was instituted 2 weeks after onset of symptoms, but failed to eradicate the infection. the patient recovered after treatment with local and systemic amphotericin B, systemic 5-fluo-rocytosine and surgical synovectomy. Quantitation of joint cartilage proteoglycan fragments in synovia! fluid indicated extensive breakdown of cartilage during the acute phase of arthritis but, parallel to clinical recovery, these levels returned to normal. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Orthopaedica
volume
64
issue
6
pages
4 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:0027744148
ISSN
1745-3674
DOI
10.3109/17453679308994601
language
English
LU publication?
no
id
e8178eeb-3e16-447b-bbda-c5a22249fbac
date added to LUP
2016-05-04 18:27:00
date last changed
2016-11-08 15:05:28
@misc{e8178eeb-3e16-447b-bbda-c5a22249fbac,
  abstract     = {<p>A nonimmunocompromised 32-year-old man with arthrosis of the knee participated as a placebo control in a clinical trial of intraarticular injections of hya-luronan. After the fourth weekly injection of saline, he developed a warm and swollen knee, and synovia! fluid cultures revealed growth of Candida albicans. Oral fluconazole treatment was instituted 2 weeks after onset of symptoms, but failed to eradicate the infection. the patient recovered after treatment with local and systemic amphotericin B, systemic 5-fluo-rocytosine and surgical synovectomy. Quantitation of joint cartilage proteoglycan fragments in synovia! fluid indicated extensive breakdown of cartilage during the acute phase of arthritis but, parallel to clinical recovery, these levels returned to normal. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.</p>},
  author       = {Christensson, Bertil and Ryd, Leif and Dahlberg, Leif and Lohmander, Stefan},
  issn         = {1745-3674},
  language     = {eng},
  number       = {6},
  pages        = {695--698},
  publisher    = {ARRAY(0xa134880)},
  series       = {Acta Orthopaedica},
  title        = {Candida albicans arthritis in a nonimmuno-compromised patient : Complication of placebo intraarticular injections},
  url          = {http://dx.doi.org/10.3109/17453679308994601},
  volume       = {64},
  year         = {1993},
}