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Fetal Cortisol and the Initiation of Labour in the Human

Gennser, Gerhard; Ohrlander, Sten and Eneroth, Peter LU (2008) In Ciba Foundation Symposium 47 - The Fetus and Birth 47. p.401-426
Abstract

The role of the fetal adrenal activity in the initiation of parturition in the human has been investigated. Women were studied in the last trimester of pregnancy during treatment with betamethasone for prevention of the idiopathic respiratory distress syndrome. Although betamethasone caused a considerable drop in the cortisol concentrations of fetal plasma and amniotic fluid, the time to spontaneous delivery in this group was similar to that in matched controls. Moreover, cortisol in fetal scalp blood at the onset of parturition in untreated women did not differ between those with spontaneous and those with induced labour. Evidence is given that increase of circulating cortisol in the fetus during the course of parturition predominantly... (More)

The role of the fetal adrenal activity in the initiation of parturition in the human has been investigated. Women were studied in the last trimester of pregnancy during treatment with betamethasone for prevention of the idiopathic respiratory distress syndrome. Although betamethasone caused a considerable drop in the cortisol concentrations of fetal plasma and amniotic fluid, the time to spontaneous delivery in this group was similar to that in matched controls. Moreover, cortisol in fetal scalp blood at the onset of parturition in untreated women did not differ between those with spontaneous and those with induced labour. Evidence is given that increase of circulating cortisol in the fetus during the course of parturition predominantly reflects a rise in maternal cortisol underthe influence of labour. The strain of labour seems to partly override the betamethasone-induced inhibition of maternal cortisol release. The possible ability of the fetal adrenals to respond to stimuli is illustrated by comparison of cortisol concentrations in cord plasma after various forms of complicated deliveries.

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Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Betamethasone, Cord plasma, Fetal cortisol, Parturition, Pregnancy
in
Ciba Foundation Symposium 47 - The Fetus and Birth
editor
Knight, Julie and O'Connor, Maeve
volume
47
pages
26 pages
publisher
Interscience Wiley
external identifiers
  • Scopus:84961385039
ISBN
9780470720295
9789021940533
DOI
10.1002/9780470720295.ch17
language
English
LU publication?
no
id
e88cfb02-efba-43b0-9720-0ea7f5c451b4
date added to LUP
2016-05-18 17:43:21
date last changed
2016-07-15 09:28:20
@misc{e88cfb02-efba-43b0-9720-0ea7f5c451b4,
  abstract     = {<p>The role of the fetal adrenal activity in the initiation of parturition in the human has been investigated. Women were studied in the last trimester of pregnancy during treatment with betamethasone for prevention of the idiopathic respiratory distress syndrome. Although betamethasone caused a considerable drop in the cortisol concentrations of fetal plasma and amniotic fluid, the time to spontaneous delivery in this group was similar to that in matched controls. Moreover, cortisol in fetal scalp blood at the onset of parturition in untreated women did not differ between those with spontaneous and those with induced labour. Evidence is given that increase of circulating cortisol in the fetus during the course of parturition predominantly reflects a rise in maternal cortisol underthe influence of labour. The strain of labour seems to partly override the betamethasone-induced inhibition of maternal cortisol release. The possible ability of the fetal adrenals to respond to stimuli is illustrated by comparison of cortisol concentrations in cord plasma after various forms of complicated deliveries.</p>},
  author       = {Gennser, Gerhard and Ohrlander, Sten and Eneroth, Peter},
  editor       = {Knight, Julie and O'Connor, Maeve},
  isbn         = {9780470720295},
  keyword      = {Betamethasone,Cord plasma,Fetal cortisol,Parturition,Pregnancy},
  language     = {eng},
  month        = {05},
  pages        = {401--426},
  publisher    = {ARRAY(0xa2eda08)},
  series       = {Ciba Foundation Symposium 47 - The Fetus and Birth},
  title        = {Fetal Cortisol and the Initiation of Labour in the Human},
  url          = {http://dx.doi.org/10.1002/9780470720295.ch17},
  volume       = {47},
  year         = {2008},
}