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Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice

Wang, Y LU ; Sugiyama, H; Axelson, H LU ; Panda, C K; Babonits, M; Ma, A; Steinberg, J M; Alt, F W; Klein, G and Wiener, F (1992) In Oncogene 7(6). p.7-1241
Abstract

Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by... (More)

Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.

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Contribution to journal
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published
keywords
Abelson murine leukemia virus, Animals, Carcinogens, DNA, DNA, Neoplasm, Enhancer Elements, Genetic, Genes, Immunoglobulin, Genes, myc, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Introns, Mice, Mice, Transgenic, Plasmacytoma, RNA, RNA, Neoplasm, Terpenes, Translocation, Genetic
in
Oncogene
volume
7
issue
6
pages
7 pages
publisher
Nature Publishing Group
external identifiers
  • Scopus:0026583062
ISSN
0950-9232
language
English
LU publication?
yes
id
eadcf944-2dfe-4770-ac08-8a05413060a7
date added to LUP
2016-08-09 09:20:17
date last changed
2016-11-14 09:42:59
@misc{eadcf944-2dfe-4770-ac08-8a05413060a7,
  abstract     = {<p>Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. &amp; Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.</p>},
  author       = {Wang, Y and Sugiyama, H and Axelson, H and Panda, C K and Babonits, M and Ma, A and Steinberg, J M and Alt, F W and Klein, G and Wiener, F},
  issn         = {0950-9232},
  keyword      = {Abelson murine leukemia virus,Animals,Carcinogens,DNA,DNA, Neoplasm,Enhancer Elements, Genetic,Genes, Immunoglobulin,Genes, myc,Immunoglobulin Heavy Chains,Immunoglobulin Light Chains,Introns,Mice,Mice, Transgenic,Plasmacytoma,RNA,RNA, Neoplasm,Terpenes,Translocation, Genetic},
  language     = {eng},
  number       = {6},
  pages        = {7--1241},
  publisher    = {ARRAY(0x7fd00a0)},
  series       = {Oncogene},
  title        = {Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice},
  volume       = {7},
  year         = {1992},
}