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Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases

Spelt, Lidewij LU ; Sasor, Agata; Ansari, Daniel LU and Andersson, Roland LU (2016) In Scandinavian Journal of Gastroenterology p.1-6
Abstract

Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. Details on patient characteristics, the primary colon cancer operation and metastatic disease were collected. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: Median OS and DFS were 67 and 20 months, respectively. 1-, 3- and 5-year OS were 97, 76, and 52%. 1-, 3- and 5-year DFS were 65, 42, and 37%.... (More)

Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. Details on patient characteristics, the primary colon cancer operation and metastatic disease were collected. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: Median OS and DFS were 67 and 20 months, respectively. 1-, 3- and 5-year OS were 97, 76, and 52%. 1-, 3- and 5-year DFS were 65, 42, and 37%. Multivariate analysis showed LNR to be an independent predictive factor for DFS but not for OS. Other identified predictive factors were vascular and perineural invasion of the primary colon cancer, size of the largest metastasis and severe complications after liver surgery for OS, and perineural invasion, number of liver metastases and preoperative CEA-level for DFS. Traditional N-stage was also considered to be an independent predictive factor for DFS in a separate multivariate analysis. Conclusions: LNR and perineural invasion of the primary colon cancer can be used as a prognostic variable for DFS after a concomitant liver resection for colon cancer metastases. Vascular and perineural invasion of the primary colon cancer are predictive for OS.

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author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
Colonic neoplasms, disease-free survival, liver resection, lymph nodes, metastasis, survival analysis
in
Scandinavian Journal of Gastroenterology
pages
6 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:84976905643
ISSN
0036-5521
DOI
10.1080/00365521.2016.1190400
language
English
LU publication?
yes
id
f0ad2e68-ebeb-4acf-b369-3672b6f83d3c
date added to LUP
2016-07-20 10:25:43
date last changed
2016-09-20 03:07:12
@misc{f0ad2e68-ebeb-4acf-b369-3672b6f83d3c,
  abstract     = {<p>Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. Details on patient characteristics, the primary colon cancer operation and metastatic disease were collected. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: Median OS and DFS were 67 and 20 months, respectively. 1-, 3- and 5-year OS were 97, 76, and 52%. 1-, 3- and 5-year DFS were 65, 42, and 37%. Multivariate analysis showed LNR to be an independent predictive factor for DFS but not for OS. Other identified predictive factors were vascular and perineural invasion of the primary colon cancer, size of the largest metastasis and severe complications after liver surgery for OS, and perineural invasion, number of liver metastases and preoperative CEA-level for DFS. Traditional N-stage was also considered to be an independent predictive factor for DFS in a separate multivariate analysis. Conclusions: LNR and perineural invasion of the primary colon cancer can be used as a prognostic variable for DFS after a concomitant liver resection for colon cancer metastases. Vascular and perineural invasion of the primary colon cancer are predictive for OS.</p>},
  author       = {Spelt, Lidewij and Sasor, Agata and Ansari, Daniel and Andersson, Roland},
  issn         = {0036-5521},
  keyword      = {Colonic neoplasms,disease-free survival,liver resection,lymph nodes,metastasis,survival analysis},
  language     = {eng},
  month        = {06},
  pages        = {1--6},
  publisher    = {ARRAY(0xb54d7c8)},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases},
  url          = {http://dx.doi.org/10.1080/00365521.2016.1190400},
  year         = {2016},
}