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Body fluid markers of cartilage changes in osteoarthritis

Thonar, E. J M A; Shinmei, M. and Lohmander, L. S. LU (1993) In Rheumatic Disease Clinics of North America 19(3). p.635-657
Abstract

Various markers of the metabolism of articular cartilage have been identified in synovial fluid, blood, and urine of patients with osteoarthritis (OA). The joint fluid level of a cartilage-derived molecule, or its fragment, can be used as a marker of the synthesis or catabolism of that molecule in the articular surfaces within that joint. In blood and urine, on the other hand, the level of a marker is useful in assessing systemic changes affecting the metabolism of a molecule in all the cartilages in the body. Quantification of specific markers in body fluids already has proved useful in identifying increased catabolic as well as anabolic activities in articular cartilage during preradiologic as well as later stages of OA. The markers... (More)

Various markers of the metabolism of articular cartilage have been identified in synovial fluid, blood, and urine of patients with osteoarthritis (OA). The joint fluid level of a cartilage-derived molecule, or its fragment, can be used as a marker of the synthesis or catabolism of that molecule in the articular surfaces within that joint. In blood and urine, on the other hand, the level of a marker is useful in assessing systemic changes affecting the metabolism of a molecule in all the cartilages in the body. Quantification of specific markers in body fluids already has proved useful in identifying increased catabolic as well as anabolic activities in articular cartilage during preradiologic as well as later stages of OA. The markers also can be sued for monitoring the effect of drugs on cartilage matrix molecules and in differentiating among different subtypes of osteoarthritis. Markers should prove most useful in prospective studies aimed at identifying early changes in cartilage metabolism in humans at high risk for developing OA.

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organization
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Contribution to journal
publication status
published
subject
in
Rheumatic Disease Clinics of North America
volume
19
issue
3
pages
23 pages
publisher
Elsevier
external identifiers
  • Scopus:0027257244
ISSN
0889-857X
language
English
LU publication?
yes
id
f4ef42b9-3e45-40d0-80bc-8c4369f76daf
date added to LUP
2016-05-04 18:31:58
date last changed
2016-07-04 13:16:11
@misc{f4ef42b9-3e45-40d0-80bc-8c4369f76daf,
  abstract     = {<p>Various markers of the metabolism of articular cartilage have been identified in synovial fluid, blood, and urine of patients with osteoarthritis (OA). The joint fluid level of a cartilage-derived molecule, or its fragment, can be used as a marker of the synthesis or catabolism of that molecule in the articular surfaces within that joint. In blood and urine, on the other hand, the level of a marker is useful in assessing systemic changes affecting the metabolism of a molecule in all the cartilages in the body. Quantification of specific markers in body fluids already has proved useful in identifying increased catabolic as well as anabolic activities in articular cartilage during preradiologic as well as later stages of OA. The markers also can be sued for monitoring the effect of drugs on cartilage matrix molecules and in differentiating among different subtypes of osteoarthritis. Markers should prove most useful in prospective studies aimed at identifying early changes in cartilage metabolism in humans at high risk for developing OA.</p>},
  author       = {Thonar, E. J M A and Shinmei, M. and Lohmander, L. S.},
  issn         = {0889-857X},
  language     = {eng},
  number       = {3},
  pages        = {635--657},
  publisher    = {ARRAY(0x9350a40)},
  series       = {Rheumatic Disease Clinics of North America},
  title        = {Body fluid markers of cartilage changes in osteoarthritis},
  volume       = {19},
  year         = {1993},
}