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Subjective sleep problems in Huntington's disease : A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function

Baker, Chaya Rochel; Domínguez D, Juan F.; Stout, Julie C.; Gabery, Sanaz LU ; Churchyard, Andrew; Chua, Phyllis; Egan, Gary F.; Petersén, Åsa LU ; Georgiou-Karistianis, Nellie and Poudel, Govinda R. (2016) In Journal of the Neurological Sciences 364. p.148-153
Abstract

Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retrospective pilot study used brain volume, neurocognitive and neuropsychiatric data from premanifest (pre-HD) and symptomatic HD (symp-HD). Subjective sleep problem was measured using the sleep item of the Beck's Depression Inventory-II (BDI-II). Pre-HD individuals reporting sleep problems had significantly poorer neuropsychiatric outcomes compared... (More)

Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retrospective pilot study used brain volume, neurocognitive and neuropsychiatric data from premanifest (pre-HD) and symptomatic HD (symp-HD). Subjective sleep problem was measured using the sleep item of the Beck's Depression Inventory-II (BDI-II). Pre-HD individuals reporting sleep problems had significantly poorer neuropsychiatric outcomes compared to those not reporting sleep problems. In the symp-HD group, those with sleep problems had significantly accelerated thalamic degeneration and poorer neuropsychiatric outcomes compared to those without sleep problems. There was no relationship between subjective sleep problems and neurocognitive measures. These findings suggest an association between subjective sleep disturbance, neuropathology, and development of neuropsychiatric symptoms in HD. Further studies using quantitative EEG-based monitoring of sleep in HD and changes in the brain and behaviour will be necessary to establish the causal nature of this relationship.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Huntington's disease, Neurodegeneration, Sleep disturbances
in
Journal of the Neurological Sciences
volume
364
pages
6 pages
publisher
Elsevier
external identifiers
  • Scopus:84962375327
ISSN
0022-510X
DOI
10.1016/j.jns.2016.03.021
language
English
LU publication?
yes
id
f7658f25-6f4c-4ab4-8921-03d5fee053d6
date added to LUP
2016-05-10 08:13:55
date last changed
2016-09-28 11:07:53
@misc{f7658f25-6f4c-4ab4-8921-03d5fee053d6,
  abstract     = {<p>Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retrospective pilot study used brain volume, neurocognitive and neuropsychiatric data from premanifest (pre-HD) and symptomatic HD (symp-HD). Subjective sleep problem was measured using the sleep item of the Beck's Depression Inventory-II (BDI-II). Pre-HD individuals reporting sleep problems had significantly poorer neuropsychiatric outcomes compared to those not reporting sleep problems. In the symp-HD group, those with sleep problems had significantly accelerated thalamic degeneration and poorer neuropsychiatric outcomes compared to those without sleep problems. There was no relationship between subjective sleep problems and neurocognitive measures. These findings suggest an association between subjective sleep disturbance, neuropathology, and development of neuropsychiatric symptoms in HD. Further studies using quantitative EEG-based monitoring of sleep in HD and changes in the brain and behaviour will be necessary to establish the causal nature of this relationship.</p>},
  author       = {Baker, Chaya Rochel and Domínguez D, Juan F. and Stout, Julie C. and Gabery, Sanaz and Churchyard, Andrew and Chua, Phyllis and Egan, Gary F. and Petersén, Åsa and Georgiou-Karistianis, Nellie and Poudel, Govinda R.},
  issn         = {0022-510X},
  keyword      = {Huntington's disease,Neurodegeneration,Sleep disturbances},
  language     = {eng},
  month        = {05},
  pages        = {148--153},
  publisher    = {ARRAY(0xad24ce8)},
  series       = {Journal of the Neurological Sciences},
  title        = {Subjective sleep problems in Huntington's disease : A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function},
  url          = {http://dx.doi.org/10.1016/j.jns.2016.03.021},
  volume       = {364},
  year         = {2016},
}