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14C bomb-pulse dating and stable isotope analysis for growth rate and dietary information in breast cancer?

Lång, K. LU ; Eriksson Stenström, K. LU ; Rosso, A. LU ; Bech, M. LU ; Zackrisson, S. LU ; Graubau, D. and Mattsson, S. LU (2016) In Radiation Protection Dosimetry 169(1). p.158-164
Abstract

The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with 14C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ. Thus, this first study of tumour tissue has not yet demonstrated that 14C bomb-pulse dating can obtain information on the growth of breast cancer. However, with further refinement, involving extraction of cell types and components, there is a possibility that fundamental knowledge of tumour biology might still be gained by the bomb-pulse technique. Additionally,... (More)

The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with 14C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ. Thus, this first study of tumour tissue has not yet demonstrated that 14C bomb-pulse dating can obtain information on the growth of breast cancer. However, with further refinement, involving extraction of cell types and components, there is a possibility that fundamental knowledge of tumour biology might still be gained by the bomb-pulse technique. Additionally, δ13C and δ15N analyses were performed to obtain dietary and metabolic information, and to serve as a base for improvement of the age determination.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
169
issue
1
pages
7 pages
publisher
Nuclear Technology Publishing
external identifiers
  • Scopus:84979019852
ISSN
0144-8420
DOI
10.1093/rpd/ncw107
language
English
LU publication?
yes
id
fba1fdfd-236b-4568-8b8f-40aba7c518aa
date added to LUP
2016-08-15 11:16:08
date last changed
2016-11-08 15:05:35
@misc{fba1fdfd-236b-4568-8b8f-40aba7c518aa,
  abstract     = {<p>The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with <sup>14</sup>C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ. Thus, this first study of tumour tissue has not yet demonstrated that <sup>14</sup>C bomb-pulse dating can obtain information on the growth of breast cancer. However, with further refinement, involving extraction of cell types and components, there is a possibility that fundamental knowledge of tumour biology might still be gained by the bomb-pulse technique. Additionally, δ<sup>13</sup>C and δ<sup>15</sup>N analyses were performed to obtain dietary and metabolic information, and to serve as a base for improvement of the age determination.</p>},
  author       = {Lång, K. and Eriksson Stenström, K. and Rosso, A. and Bech, M. and Zackrisson, S. and Graubau, D. and Mattsson, S.},
  issn         = {0144-8420},
  language     = {eng},
  number       = {1},
  pages        = {158--164},
  publisher    = {ARRAY(0xbdeedc8)},
  series       = {Radiation Protection Dosimetry},
  title        = {<sup>14</sup>C bomb-pulse dating and stable isotope analysis for growth rate and dietary information in breast cancer?},
  url          = {http://dx.doi.org/10.1093/rpd/ncw107},
  volume       = {169},
  year         = {2016},
}