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Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis

Rabbitts, T H; Axelson, H LU ; Forster, A; Grutz, G; Lavenir, I; Larson, R; Osada, H; Valge-Archer, V; Wadman, I and Warren, A (1997) In Leukemia 11 (Suppl 3). p.2-271
Abstract

The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Adaptor Proteins, Signal Transducing, Animals, Chromosomes, Human, Pair 11, DNA-Binding Proteins, Erythropoiesis, Hematopoiesis, Humans, LIM Domain Proteins, Leukemia-Lymphoma, Adult T-Cell, Metalloproteins, Mice, Mice, Transgenic, Proto-Oncogene Proteins, Proto-Oncogenes, Transcription, Genetic, Translocation, Genetic
in
Leukemia
volume
11
issue
Suppl 3
pages
2 pages
publisher
Nature Publishing Group
external identifiers
  • Scopus:0030795048
ISSN
0887-6924
language
English
LU publication?
yes
id
fc7a1fc0-1cd9-424a-b377-76cac3ac46cb
date added to LUP
2016-08-09 09:14:01
date last changed
2016-08-10 04:00:18
@misc{fc7a1fc0-1cd9-424a-b377-76cac3ac46cb,
  abstract     = {<p>The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.</p>},
  author       = {Rabbitts, T H and Axelson, H and Forster, A and Grutz, G and Lavenir, I and Larson, R and Osada, H and Valge-Archer, V and Wadman, I and Warren, A},
  issn         = {0887-6924},
  keyword      = {Adaptor Proteins, Signal Transducing,Animals,Chromosomes, Human, Pair 11,DNA-Binding Proteins,Erythropoiesis,Hematopoiesis,Humans,LIM Domain Proteins,Leukemia-Lymphoma, Adult T-Cell,Metalloproteins,Mice,Mice, Transgenic,Proto-Oncogene Proteins,Proto-Oncogenes,Transcription, Genetic,Translocation, Genetic},
  language     = {eng},
  number       = {Suppl 3},
  pages        = {2--271},
  publisher    = {ARRAY(0xa024560)},
  series       = {Leukemia},
  title        = {Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis},
  volume       = {11 },
  year         = {1997},
}