The Escherichia coli ftsK1 mutation attenuates the induction of sigma(s)-dependent genes upon transition to stationary phase
Diez, A A; Tunlid, Anders; Nyström, T (2002). The Escherichia coli ftsK1 mutation attenuates the induction of sigma(s)-dependent genes upon transition to stationary phase. FEMS Microbiology Letters, 206, (1), 19 - 23
|
Published
|
English
Authors:
Diez, A A
;
Tunlid, Anders
;
Nyström, T
Department:
MEMEG
Microbial Ecology
Research Group:
Microbial Ecology
Abstract:
A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene,ftsY, uncouples the otherwise coordinated induction of sigma(S)-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. (C) 2002 Federation of European Microbiological Societies, Published by Elsevier Science B.V. All rights reserved.
Cite this