Prediction of obstructive coronary artery disease from myocardial perfusion scintigraphy using deep neural networks

Arvidsson, Ida; Overgaard, Niels Christian; Aström, Kalle; Heyden, Anders, et al. (2020). Prediction of obstructive coronary artery disease from myocardial perfusion scintigraphy using deep neural networks 2020 25th International Conference on Pattern Recognition (ICPR), 4442 - 4449. 25th International Conference on Pattern Recognition, ICPR 2020. Virtual, Milan, Italy: IEEE - Institute of Electrical and Electronics Engineers Inc.
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DOI:
Conference Proceeding/Paper | Published | English
Authors:
Arvidsson, Ida ; Overgaard, Niels Christian ; Aström, Kalle ; Heyden, Anders , et al.
Department:
eSSENCE: The e-Science Collaboration
Mathematics (Faculty of Engineering)
Lund University Bioimaging Center
Centre for Mathematical Sciences
Project:
Deep learning based evaluation of coronary artery disease and estimation of quantitative coronary angiography using myocardial perfusion imaging
Abstract:

For diagnosis and risk assessment in patients with stable ischemic heart disease, myocardial perfusion scintigraphy is one of the most common cardiological examinations performed today. There are however many motivations for why an artificial intelligence algorithm would provide useful input to this task. For example to reduce the subjectiveness and save time for the nuclear medicine physicians working with this time consuming task. In this work we have developed a deep learning algorithm for multi-label classification based on a convolutional neural network to estimate the probability of obstructive coronary artery disease in the left anterior artery, left circumflex artery and right coronary artery. The prediction is based on data from myocardial perfusion scintigraphy studies conducted in a dedicated Cadmium-Zinc-Telluride cardio camera (D-SPECT Spectrum Dynamics). Data from 588 patients was available, with stress images in both upright and supine position, as well as a number of auxiliary parameters such as angina symptoms and age. The data was used to train and evaluate the algorithm using 5-fold cross-validation. We achieve state-of-the-art results for this task with an area under the receiver operating characteristics curve of 0.89 as average on per-vessel level and 0.95 on per-patient level.

Keywords:
Mathematics ; Computer Vision and Robotics (Autonomous Systems)
ISBN:
9781728188089
ISSN:
1051-4651
LUP-ID:
d3b98c37-485d-416c-8acc-4260d432fdb6 | Link: https://lup.lub.lu.se/record/d3b98c37-485d-416c-8acc-4260d432fdb6 | Statistics

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