Contrast enhanced magneto-motive ultrasound in lymph nodes-modelling and pre-clinical imaging using magnetic microbubbles

Sjostrand, Sandra; Bacou, Marion; Thomson, Adrian; Kaczmarek, Katarzyna, et al. (2022). Contrast enhanced magneto-motive ultrasound in lymph nodes-modelling and pre-clinical imaging using magnetic microbubbles 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022, 2022-July,, 194 - 197. 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022. Glasgow, United Kingdom: IEEE - Institute of Electrical and Electronics Engineers Inc.
Download:
DOI:
Conference Proceeding/Paper | Published | English
Authors:
Sjostrand, Sandra ; Bacou, Marion ; Thomson, Adrian ; Kaczmarek, Katarzyna , et al.
Department:
Department of Biomedical Engineering
Biomedical Engineering, Lund
Medical ultrasound
LTH Profile Area: Engineering Health
LTH Profile Area: Photon Science and Technology
Department of Biomedical Engineering
Medicon Bridge
Research Group:
Medical ultrasound
Medicon Bridge
Abstract:

Despite advances in MRI, the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterization of cancer tissues. We report proof-of-concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interrogate tissue mechanical properties through magnetically induced tissue deformations. The feasibility of the proposed application was explored using a combination of pre-clinical ultrasound imaging and finite element analysis. First, contrast enhanced ultrasound imaging on one wild type mouse recorded lymphatic drainage of magnetic microbubbles after bolus injection. Second, preliminary CE-MMUS data were acquired as a proof of concept. Third, the magneto-mechanical interactions of a magnetic microbubble with an elastic solid were simulated using finite element software. Accumulation of magnetic microbubbles in the inguinal lymph node was verified using contrast enhanced ultrasound, with peak enhancement occurring 3.7 s post-injection. Preliminary CE-MMUS indicates the presence of magnetic contrast agent in the lymph node. The finite element analysis explores how the magnetic force is transferred to motion of the solid, which depends on elasticity and bubble radius, indicating an inverse relation with displacement. Combining magnetic microbubbles with MMUS could harness the advantages of both techniques, to provide perfusion information, robust lymph node delineation and characterisation based on mechanical properties. Clinical Relevance-Robust detection and characterisation of lymph nodes could be aided by visualising lymphatic drainage of magnetic microbubbles using contrast enhanced ultrasound imaging and magneto-motion, which is dependent on tissue mechanical properties.

ISBN:
9781728127828
ISSN:
1557-170X
LUP-ID:
dc92d24b-152d-4422-8be5-be7dd0c58dd0 | Link: https://lup.lub.lu.se/record/dc92d24b-152d-4422-8be5-be7dd0c58dd0 | Statistics

Cite this