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Lund University Lund University Publications2000-01-01T00:00+00:001dailyPrevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes : Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children
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Lindgren, MarieNorström, FredrikPersson, MartinaElding Larsson, HelenaForsander, GunÅkesson, KarinSamuelsson, UlfLudvigsson, JohnnyCarlsson, Annelie2024-04-01OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis study in Sweden.RESULTS: The prevalence of biopsy-proven CD was 9.8%, of which 58.2% already had a CD diagnosis before or at T1D onset. Almost all, 95.9%, were diagnosed with CD within 5 years after the T1D diagnosis. Younger age at the T1D diagnosis and being homozygote for DQ2 increased the risk of CD after T1D, but neither sex nor diabetes-related autoantibodies were associated with the risk.CONCLUSIONS: Age at and time after diabetes diagnosis should be considered in screening guidelines for CD in children with T1D.https://lup.lub.lu.se/record/6f77e4e1-8bf7-4bb4-893f-d4e6284b4a91http://dx.doi.org/10.2337/dc23-1671pmid:38363973engDiabetes Care; 47(4), pp 756-760 (2024)ISSN: 1935-5548Endocrinology and DiabetesChildAdolescentHumansInfantDiabetes Mellitus, Type 1/complicationsCeliac Disease/complicationsSweden/epidemiologyLongitudinal StudiesPrevalenceCohort StudiesAutoantibodiesPrevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes : Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Childrencontributiontojournal/articleinfo:eu-repo/semantics/articletext