Lund University Publications
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Lund University Lund University Publications
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Association of excessive daytime sleepiness with the zung self-rated depression subscales in adults with coronary artery disease and obstructive sleep apnea
https://lup.lub.lu.se/search/publication/dfe3b658-c107-4dd0-990b-cd715c31f533
Celik, Yeliz
Yapici-Eser, Hale
Balcan, Baran
Peker, Yüksel
2021-07
Excessive daytime sleepiness (EDS) is a factor associated with both obstructive sleep apnea (OSA) and depressive symptoms. Continuous positive airway pressure (CPAP) treatment may decrease EDS in adults with OSA; however, the modulatory role of depressive symptoms on the improvement of EDS is not known. We aimed to explore the association between subscales of the Zung Self-rated Depression Scale (SDS) and Epworth Sleepiness Scale (ESS) over a 2-year period in coronary artery disease (CAD) patients with OSA. This was a post-hoc analysis of the RICCADSA cohort, in which 399 adults with CAD (155 sleepy OSA [apnea–hypopnea index ≥ 15/h] and ESS score ≥ 10, who were offered CPAP; and 244 nonsleepy OSA [ESS < 10]), randomized to CPAP [n = 122] or no-CPAP [n = 122]) were included. Three factors were extracted from the Zung SDS, based on the principal component analysis: F1, cognitive symptoms and anhedonia; F2, negative mood; and F3, appetite. In a mixed model, the ESS score decreased by 3.4 points (p < 0.001) among the sleepy OSA phenotype, which was predicted by the decline in the F2, but not in the F1 and F3 scores. The fixed effects of time were not significant in the nonsleepy OSA groups, and thus, further analyses were not applicable. Additional within-group analyses showed a significant decrease in all subscales over time both in the sleepy and nonsleepy OSA patients on CPAP whereas there was a significant increase in the nonsleepy OSA group randomized to no-CPAP. We conclude that the improvement in negative mood symptoms of depression, but not changes in cognitive symptoms and anhedonia as well as appetite, was a significant predictor of decline in the ESS scores over a 2-year period in this CAD cohort with sleepy OSA on CPAP treatment.
https://lup.lub.lu.se/record/dfe3b658-c107-4dd0-990b-cd715c31f533
http://dx.doi.org/10.3390/diagnostics11071176
scopus:85110045543
pmid:34203553
eng
Diagnostics; 11(7), no 1176 (2021)
ISSN: 2075-4418
Respiratory Medicine and Allergy
Cardiac and Cardiovascular Systems
Coronary artery disease
Depression
Excessive daytime sleepiness
Obstructive sleep apnea
Zung SDS
Association of excessive daytime sleepiness with the zung self-rated depression subscales in adults with coronary artery disease and obstructive sleep apnea
contributiontojournal/article
info:eu-repo/semantics/article
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Unraveling human aqp5-pip molecular interaction and effect on aqp5 salivary glands localization in ss patients
https://lup.lub.lu.se/search/publication/c757bbca-50a0-4624-b1c4-6392fbf44368
Chivasso, Clara
Nesverova, Veronika
Järvå, Michael
Blanchard, Anne
Rose, Kristie L.
Öberg, Fredrik Kryh
Wang, Zhen
Martin, Maud
Lhotellerie, Florent
Zindy, Egor
Junqueira, Bruna
Leroy, Karelle
Vanhollebeke, Benoit
Delforge, Valérie
Bolaky, Nargis
Perret, Jason
Soyfoo, Muhammad Shahnawaz
Moscato, Stefania
Baldini, Chiara
Chaumont, François
Mattii, Letizia
Schey, Kevin L.
Myal, Yvonne
Törnroth-Horsefield, Susanna
Delporte, Christine
2021-08
Saliva secretion requires effective translocation of aquaporin 5 (AQP5) water channel to the salivary glands (SGs) acinar apical membrane. Patients with Sjögren’s syndrome (SS) display abnormal AQP5 localization within acinar cells from SGs that correlate with sicca manifestation and glands hypofunction. Several proteins such as Prolactin-inducible protein (PIP) may regulate AQP5 trafficking as observed in lacrimal glands from mice. However, the role of the AQP5-PIP complex remains poorly understood. In the present study, we show that PIP interacts with AQP5 in vitro and in mice as well as in human SGs and that PIP misexpression correlates with an altered AQP5 distribution at the acinar apical membrane in PIP knockout mice and SS hMSG. Furthermore, our data show that the protein-protein interaction involves the AQP5 C-terminus and the N-terminal of PIP (one molecule of PIP per AQP5 tetramer). In conclusion, our findings highlight for the first time the role of PIP as a protein controlling AQP5 localization in human salivary glands but extend beyond due to the PIP-AQP5 interaction described in lung and breast cancers.
https://lup.lub.lu.se/record/c757bbca-50a0-4624-b1c4-6392fbf44368
http://dx.doi.org/10.3390/cells10082108
scopus:85113491858
pmid:34440877
eng
Cells; 10(8), no 2108 (2021)
ISSN: 2073-4409
Cell and Molecular Biology
Rheumatology and Autoimmunity
Aquaporin-5
Prolactin-inducible protein
Salivary gland
Sjögren’s syndrome
Unraveling human aqp5-pip molecular interaction and effect on aqp5 salivary glands localization in ss patients
contributiontojournal/article
info:eu-repo/semantics/article
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Self-Transcendence as a Buffer Against COVID-19 Suffering : The Development and Validation of the Self-Transcendence Measure-B
https://lup.lub.lu.se/search/publication/a580ec11-187d-4eba-9460-dae55d0a96a5
Wong, Paul T.P.
Arslan, Gökmen
Bowers, Victoria L.
Peacock, Edward J.
Kjell, Oscar Nils Erik
Ivtzan, Itai
Lomas, Tim
2021-10-06
The age of COVID-19 calls for a different approach toward global well-being and flourishing through the transcendence suffering as advocated by existential positive psychology. In the present study, we primarily explained what self-transcendence is and why it represents the most promising path for human beings to flourish through the transformation of suffering in a difficult and uncertain world. After reviewing the literature on self-transcendence experiences, we concluded that the model of self-transcendence presented by Frankl is able to integrate both of the characteristics associated with self-transcendence. Afterward, we discussed how the self-transcendence paradigm proposed by Wong, an extension of the model by Frankl, may help awaken our innate capacity for connections with the true self, with others, and with God or something larger than oneself. We presented self-transcendence as a less-traveled but more promising route to achieve personal growth and mental health in troubled times. Finally, we presented the history of the development and psychometrics of the Self-Transcendence Measure-Brief (STM-B) and reported the empirical evidence that self-transcendence served as a buffer against COVID-19 suffering. The presented data in the current study suggested that the best way to overcome pandemic suffering and mental health crises is to cultivate self-transcendence.
https://lup.lub.lu.se/record/a580ec11-187d-4eba-9460-dae55d0a96a5
http://dx.doi.org/10.3389/fpsyg.2021.648549
scopus:85114326980
pmid:34690853
eng
Frontiers in Psychology; 12, no 648549 (2021)
ISSN: 1664-1078
Psychology
COVID-19
existential positive psychology (PP2.0)
existential psychology
mature happiness
meaning
positive psychology
self-transcendence
wellbeing
Self-Transcendence as a Buffer Against COVID-19 Suffering : The Development and Validation of the Self-Transcendence Measure-B
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info:eu-repo/semantics/article
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Helium identification with LHCb
https://lup.lub.lu.se/search/publication/84873b1e-9c4c-4013-b3e3-c26fe5247563
Aaij, R.
Ruiz-Vidal, Joan
Zunica, G.
2024
The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √s = 13 TeV recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of 5.5 fb−1. A total of around 105 helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately 50% with a corresponding background rejection rate of up to O(1012). These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei. © 2024 Institute of Physics. All rights reserved.
https://lup.lub.lu.se/record/84873b1e-9c4c-4013-b3e3-c26fe5247563
http://dx.doi.org/10.1088/1748-0221/19/02/P02010
scopus:85185549843
eng
Journal of Instrumentation; 19(2), no P02010 (2024)
ISSN: 1748-0221
Accelerator Physics and Instrumentation
Subatomic Physics
dE/dx detectors
Ion identification systems
Large detector systems for particle and astroparticle physics
Particle identification methods
Astrophysics
Tellurium compounds
Astroparticle physics
De/dx detector
Detector systems
Helium nuclei
Ion identification system
Ion identifications
Large detector system for particle and astroparticle physic
Large detectors
Measurements of
Particle Identification Method
Helium
Helium identification with LHCb
contributiontojournal/article
info:eu-repo/semantics/article
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Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019
https://lup.lub.lu.se/search/publication/4ab47e93-2e83-418f-b56f-2c55c6ad7573
Albinsson, Bo
Hoffman, Tove
Kolstad, Linda
Bergström, Tomas
Bogdanovic, Gordana
Heydecke, Anna
Hägg, Mirja
Kjerstadius, Torbjörn
Lindroth, Ylva
Petersson, Annika
Stenberg, Marie
Vene, Sirkka
Ellström, Patrik
Rönnberg, Bengt
Lundkvist, Åke
2024-01
Background: In Sweden, information on seroprevalence of tick-borne encephalitis virus (TBEV) in the population, including vaccination coverage and infection, is scattered. This is largely due to the absence of a national tick-borne encephalitis (TBE) vaccination registry, scarcity of previous serological studies and use of serological methods not distinguishing between antibodies induced by vaccination and infection. Furthermore, the number of notified TBE cases in Sweden has continued to increase in recent years despite increased vaccination. Aim: The aim was to estimate the TBEV seroprevalence in Sweden. Methods: In 2018 and 2019, 2,700 serum samples from blood donors in nine Swedish regions were analysed using a serological method that can distinguish antibodies induced by vaccination from antibodies elicited by infection. The regions were chosen to reflect differences in notified TBE incidence. Results: The overall seroprevalence varied from 9.7% (95% confidence interval (CI): 6.6–13.6%) to 64.0% (95% CI: 58.3–69.4%) between regions. The proportion of vaccinated individuals ranged from 8.7% (95% CI: 5.8–12.6) to 57.0% (95% CI: 51.2–62.6) and of infected from 1.0% (95% CI: 0.2–3.0) to 7.0% (95% CI: 4.5–10.7). Thus, more than 160,000 and 1,600,000 individuals could have been infected by TBEV and vaccinated against TBE, respectively. The mean manifestation index was 3.1%. Conclusion: A difference was observed between low- and high-incidence TBE regions, on the overall TBEV seroprevalence and when separated into vaccinated and infected individuals. The estimated incidence and manifestation index argue that a large proportion of TBEV infections are not diagnosed.
https://lup.lub.lu.se/record/4ab47e93-2e83-418f-b56f-2c55c6ad7573
http://dx.doi.org/10.2807/1560-7917.ES.2024.29.2.2300221
scopus:85182091674
pmid:38214080
eng
Eurosurveillance; 29(2) (2024)
ISSN: 1025-496X
Infectious Medicine
Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019
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info:eu-repo/semantics/article
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LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
https://lup.lub.lu.se/search/publication/67291f8f-9975-41f0-8a5f-8478a6798ea1
Garza, Raquel
Atacho, Diahann A M
Adami, Anita
Gerdes, Patricia
Vinod, Meghna
Hsieh, PingHsun
Karlsson, Ofelia
Horvath, Vivien
Johansson, Pia A
Pandiloski, Ninoslav
Matas-Fuentes, Jon
Quaegebeur, Annelies
Kouli, Antonina
Sharma, Yogita
Jönsson, Marie E
Monni, Emanuela
Englund, Elisabet
Eichler, Evan E
Gale Hammell, Molly
Barker, Roger A
Kokaia, Zaal
Douse, Christopher H
Jakobsson, Johan
2023-11-03
The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demonstrate that L1 promoters are dynamically active in the developing and the adult human brain. L1s generate hundreds of developmentally regulated and cell type-specific transcripts, many that are co-opted as chimeric transcripts or regulatory RNAs. One L1-derived long noncoding RNA, LINC01876, is a human-specific transcript expressed exclusively during brain development. CRISPR interference silencing of LINC01876 results in reduced size of cerebral organoids and premature differentiation of neural progenitors, implicating L1s in human-specific developmental processes. In summary, our results demonstrate that L1-derived transcripts provide a previously undescribed layer of primate- and human-specific transcriptome complexity that contributes to the functional diversification of the human brain.
https://lup.lub.lu.se/record/67291f8f-9975-41f0-8a5f-8478a6798ea1
http://dx.doi.org/10.1126/sciadv.adh9543
pmid:37910626
scopus:85175770022
eng
Science Advances; 9(44), no eadh9543 (2023)
ISSN: 2375-2548
Neurosciences
Animals
Humans
Retroelements/genetics
Transcriptome
Long Interspersed Nucleotide Elements/genetics
Neurons
Primates/genetics
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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info:eu-repo/semantics/article
text
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Momentum scale calibration of the LHCb spectrometer
https://lup.lub.lu.se/search/publication/81f434b5-4bf3-43a7-8bd2-64138194de8c
Aaij, R.
Ruiz-Vidal, Joan
Zunica, G.
2024
For accurate determination of particle masses accurate knowledge of the momentum scale of the detectors is crucial. The procedure used to calibrate the momentum scale of the LHCb spectrometer is described and illustrated using the performance obtained with an integrated luminosity of 1.6 fb−1 collected during 2016 in pp running. The procedure uses large samples of J/ → +− and B+ → J/K+ decays and leads to a relative accuracy of 3 × 10−4 on the momentum scale. © 2024 Institute of Physics. All rights reserved.
https://lup.lub.lu.se/record/81f434b5-4bf3-43a7-8bd2-64138194de8c
http://dx.doi.org/10.1088/1748-0221/19/02/P02008
scopus:85185551130
eng
Journal of Instrumentation; 19(2), no P02008 (2024)
ISSN: 1748-0221
Subatomic Physics
Analysis
Particle tracking detectors
statistical methods
Spectrometers
Analyse
Integrated luminosity
Particle mass
Particle tracking
Particle tracking detector
Performance
Relative accuracy
Scale calibration
Tracking detectors
Momentum
Momentum scale calibration of the LHCb spectrometer
contributiontojournal/article
info:eu-repo/semantics/article
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Constraining the reflective properties of WASP-178 b using CHEOPS photometry
https://lup.lub.lu.se/search/publication/ddffaeec-a309-48be-bc03-27e44e47bf3a
Pagano, I.
Davies, M.B.
Walton, N.A.
2024
Context. Multiwavelength photometry of the secondary eclipses of extrasolar planets is able to disentangle the reflected and thermally emitted light radiated from the planetary dayside. Based on this, we can measure the planetary geometric albedo Ag, which is an indicator of the presence of clouds in the atmosphere, and the recirculation efficiency ϵ, which quantifies the energy transport within the atmosphere. Aims. We measure Ag and ϵ for the planet WASP-178 b, a highly irradiated giant planet with an estimated equilibrium temperature of 2450 K. Methods. We analyzed archival spectra and the light curves collected by CHEOPS and TESS to characterize the host WASP-178, refine the ephemeris of the system, and measure the eclipse depth in the passbands of the two telescopes. Results. We measured a marginally significant eclipse depth of 70 ± 40 ppm in the TESS passband, and a statistically significant depth of 70 ± 20 ppm in the CHEOPS passband. Conclusions. Combining the eclipse-depth measurement in the CHEOPS (λeff = 6300 Å) and TESS (λeff = 8000 Å) passbands, we constrained the dayside brightness temperature of WASP-178 b in the 2250-2800 K interval. The geometric albedo 0.1< Ag0.7 makes WASP-178 b an interesting laboratory for testing the current heat-recirculation models. © The Authors 2024.
https://lup.lub.lu.se/record/ddffaeec-a309-48be-bc03-27e44e47bf3a
http://dx.doi.org/10.1051/0004-6361/202346705
scopus:85185216038
eng
Astronomy and Astrophysics; 682, no A102 (2024)
ISSN: 0004-6361
Astronomy, Astrophysics and Cosmology
planets and satellites: atmospheres
planets and satellites: detection
planets and satellites: gaseous planets
planets and satellites: individual: wasp-178 b
techniques: photometric
Exoplanets
Satellites
Solar radiation
Geometric albedos
Pass bands
Planet and satellite: gaseous planet
Planet and satellite: individual: wasp-178 b
Planets and satellites
Planets and satellites: atmospheres
Planets and satellites: detections
Planets and satellites: individual
Recirculations
Techniques: photometric
Photometry
Constraining the reflective properties of WASP-178 b using CHEOPS photometry
contributiontojournal/article
info:eu-repo/semantics/article
text
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CHEOPS observations of KELT-20 b/MASCARA-2 b: An aligned orbit and signs of variability from a reflective day side
https://lup.lub.lu.se/search/publication/92d966ba-0ff7-4459-9f5d-f69e7c546961
Singh, V.
Davies, M.B.
Zingales, T.
2024
Context. Occultations are windows of opportunity to indirectly peek into the dayside atmosphere of exoplanets. High-precision transit events provide information on the spin-orbit alignment of exoplanets around fast-rotating hosts. Aims. We aim to precisely measure the planetary radius and geometric albedo of the ultra-hot Jupiter (UHJ) KELT-20 b along with the spin-orbit alignment of the system. Methods. We obtained optical high-precision transits and occultations of KELT-20 b using CHEOPS observations in conjunction with simultaneous TESS observations. We interpreted the occultation measurements together with archival infrared observations to measure the planetary geometric albedo and dayside temperatures. We further used the host star's gravity-darkened nature to measure the system's obliquity. Results. We present a time-averaged precise occultation depth of 82 ± 6 ppm measured with seven CHEOPS visits and 131-7+8 from the analysis of all available TESS photometry. Using these measurements, we precisely constrain the geometric albedo of KELT-20 b to 0.26 ± 0.04 and the brightness temperature of the dayside hemisphere to 2566-80+77 K. Assuming Lambertian scattering law, we constrain the Bond albedo to 0.36-0.05+0.04 along with a minimal heat transfer to the night side (Ïμ = 0.14-0.10+0.13). Furthermore, using five transit observations we provide stricter constraints of 3 9 ± 1 1 deg on the sky-projected obliquity of the system. Conclusions. The aligned orbit of KELT-20 b is in contrast to previous CHEOPS studies that have found strongly inclined orbits for planets orbiting other A-type stars. The comparably high planetary geometric albedo of KELT-20 b corroborates a known trend of strongly irradiated planets being more reflective. Finally, we tentatively detect signs of temporal variability in the occultation depths, which might indicate variable cloud cover advecting onto the planetary day side. © The Author(s) 2024.
https://lup.lub.lu.se/record/92d966ba-0ff7-4459-9f5d-f69e7c546961
http://dx.doi.org/10.1051/0004-6361/202347533
scopus:85186624090
eng
Astronomy and Astrophysics; 683, no A1 (2024)
ISSN: 0004-6361
Astronomy, Astrophysics and Cosmology
Planets and satellites: atmospheres
Planets and satellites: gaseous planets
Planets and satellites: individual: KELT-20 b
Planets and satellites: individual: MASCARA-2 b
Techniques: photometric
Exoplanets
Geometry
Heat transfer
Photometry
Satellites
Solar radiation
Stars
Exo-planets
Geometric albedos
Planet and satellite: gaseous planet
Planet and satellite: individual: KELT-20 b
Planet and satellite: individual: MASCARA-2 b
Planets and satellites
Planets and satellites: individual
Orbits
CHEOPS observations of KELT-20 b/MASCARA-2 b: An aligned orbit and signs of variability from a reflective day side
contributiontojournal/article
info:eu-repo/semantics/article
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
https://lup.lub.lu.se/search/publication/161979b2-f6d8-4bfd-8810-34380c865810
De Marchi, Tommaso
Lai, Chun-Fui
Simmons, Georgia M
Goldsbrough, Isabella
Harrod, Alison
Lam, Thai
Buluwela, Lakjaya
Kjellström, Sven
Brueffer, Christian
Saal, Lao H
Malmström, Johan
Ali, Simak
Niméus, Emma
2024-03-22
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cells to proliferate by employing mechanisms within and without direct regulation by the ER. Although subjected to extensive genetic and transcriptomic analyses, understanding of protein alterations remains poorly investigated. Towards this, we employed an integrated mass spectrometry based proteomic approach to profile the protein and phosphoprotein differences in breast cancer cell lines expressing the frequent Y537N and Y537S ER mutations. Global proteome analysis revealed enrichment of mitotic and immune signaling pathways in ER mutant cells, while phosphoprotein analysis evidenced enriched activity of proliferation associated kinases, in particular CDKs and mTOR. Integration of protein expression and phosphorylation data revealed pathway-dependent discrepancies (motility vs proliferation) that were observed at varying degrees across mutant and wt ER cells. Additionally, protein expression and phosphorylation patterns, while under different regulation, still recapitulated the estrogen-independent phenotype of ER mutant cells. Our study is the first proteome-centric characterization of ESR1 mutant models, out of which we confirm estrogen independence of ER mutants and reveal the enrichment of immune signaling pathways at the proteomic level.
https://lup.lub.lu.se/record/161979b2-f6d8-4bfd-8810-34380c865810
http://dx.doi.org/10.1038/s41598-024-56412-8
pmid:38519482
eng
Scientific Reports; 14, pp 1-16 (2024)
ISSN: 2045-2322
Cancer and Oncology
Humans
Female
Cyclin-Dependent Kinases/genetics
Proteome/genetics
Proteomics
Estrogen Receptor alpha/genetics
Breast Neoplasms/pathology
Mutation
Estrogens
Receptors, Estrogen/genetics
Phosphoproteins/genetics
Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
contributiontojournal/article
info:eu-repo/semantics/article
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Ombytta roller: Marknadsliberaler och statsaktivister 1939
https://lup.lub.lu.se/search/publication/8b18c31a-12bb-4990-a2b3-2389a26cff70
Carlson, Benny
2024-03-27
https://lup.lub.lu.se/record/8b18c31a-12bb-4990-a2b3-2389a26cff70
swe
Statsvetenskaplig tidskrift; 126(1), pp 89-116 (2024)
ISSN: 0039-0747
Political Science
Ombytta roller: Marknadsliberaler och statsaktivister 1939
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Exploring the development of heterogeneous contracting capabilities : the role of organizational design
https://lup.lub.lu.se/search/publication/80814086-0b3b-4e18-8f05-efaf276d8a85
Hallberg, Niklas Lars
2024
Previous research on learning to contract and contracting capabilities suggests that firms in interorganizational relationships adopt contractual designs that economize on transaction costs, and over time learn to govern their relationships in a more efficient manner by incrementally aligning contractual terms with transaction attributes based on new experiences made in their relationships. We augment the learning to contract literature by highlighting the role of organizational design as a factor that may impact contractual learning and the development of heterogeneous contracting capabilities. Specifically, we suggest that the level of specialization and structural integration across the firm’s technical, commercial, and legal functions may affect the effectiveness of contractual learning and the type of learning likely to occur. We also outline boundary conditions for our model in terms of potential interactions between the contractual environment, organizational design, and contractual learning.
https://lup.lub.lu.se/record/80814086-0b3b-4e18-8f05-efaf276d8a85
http://dx.doi.org/10.1177/14761270241244998
eng
Strategic Organization; pp 1-43 (2024)
ISSN: 1476-1270
Business Administration
Contracting Capabilities; Learning to Contract; Organizational Design; Organizational Learning; Transaction Cost Economics
Exploring the development of heterogeneous contracting capabilities : the role of organizational design
contributiontojournal/article
info:eu-repo/semantics/article
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Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study
https://lup.lub.lu.se/search/publication/54717e80-9e8e-48b2-8ada-8ee5c06833ff
Fountoulakis, K.N.
Kazakova, O.
Smirnova, D.
2024
Background: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical depression or distress during the pandemic, also in these special populations. Methods: Chi-square tests were used for initial screening to select only those variables which would show an initial significance. Risk Ratios (RR) were calculated, and a Multiple Backward Stepwise Linear Regression Analysis (MBSLRA) was followed with those variables given significant results at screening and with the presence of distress or depression or the lack of both of them. Results: The most important risk factors for depression were female (RR = 1.59–5.49) and non-binary gender (RR = 1.56–7.41), unemployment (RR = 1.41–6.57), not working during lockdowns (RR = 1.43–5.79), bad general health (RR = 2.74–9.98), chronic somatic disorder (RR = 1.22–5.57), history of mental disorders (depression RR = 2.31–9.47; suicide attempt RR = 2.33–9.75; psychosis RR = 2.14–10.08; Bipolar disorder RR = 2.75–12.86), smoking status (RR = 1.15–5.31) and substance use (RR = 1.77–8.01). The risk factors for distress or depression that survived MBSLRA were younger age, being widowed, living alone, bad general health, being a carer, chronic somatic disorder, not working during lockdowns, being single, self-reported history of depression, bipolar disorder, self-harm, suicide attempts and of other mental disorders, smoking, alcohol, and substance use. Conclusions: Targeted preventive interventions are crucial to safeguard the mental health of vulnerable groups, emphasizing the importance of diverse samples in future research. Limitations: Online data collection may have resulted in the underrepresentation of certain population groups. © 2024
https://lup.lub.lu.se/record/54717e80-9e8e-48b2-8ada-8ee5c06833ff
http://dx.doi.org/10.1016/j.jad.2024.02.050
scopus:85186520393
eng
Journal of Affective Disorders; 352, pp 536-551 (2024)
ISSN: 0165-0327
Public Health, Global Health, Social Medicine and Epidemiology
Psychiatry
COVID-19
Depression
Mental health history
Non-binary gender
Risk factors
Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study
contributiontojournal/article
info:eu-repo/semantics/article
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Femtoscopic correlations of identical charged pions and kaons in pp collisions at s =13 TeV with event-shape selection
https://lup.lub.lu.se/search/publication/53357f36-bc89-46e6-b40c-2f701896d950
Acharya, S.
Basu, S.
Christiansen, P.
Hansen, J.
Iversen, K.E.
Matonoha, O.
Nepeivoda, R.
Ohlson, A.
Silvermyr, D.
Staa, J.
Vislavicius, V.
Zurlo, N.
2024
Collective behavior has been observed in high-energy heavy-ion collisions for several decades. Collectivity is driven by the high particle multiplicities that are produced in these collisions. At the CERN Large Hadron Collider (LHC), features of collectivity have also been seen in high-multiplicity proton-proton collisions that can attain particle multiplicities comparable to peripheral Pb-Pb collisions. One of the possible signatures of collective behavior is the decrease of femtoscopic radii extracted from pion and kaon pairs emitted from high-multiplicity collisions with increasing pair transverse momentum. This decrease can be described in terms of an approximate transverse mass scaling. In the present work, femtoscopic analyses are carried out by the ALICE Collaboration on charged pion and kaon pairs produced in pp collisions at s=13TeV from the LHC to study possible collectivity in pp collisions. The event-shape analysis method based on transverse sphericity is used to select for spherical versus jetlike events, and the effects of this selection on the femtoscopic radii for both charged pion and kaon pairs are studied. This is the first time this selection method has been applied to charged kaon pairs. An approximate transverse-mass scaling of the radii is found in all multiplicity ranges studied when the difference in the Lorentz boost for pions and kaons is taken into account. This observation does not support the hypothesis of collective expansion of hot and dense matter that should only occur in high-multiplicity events. A possible alternate explanation of the present results is based on a scenario of common emission conditions for pions and kaons in pp collisions for the multiplicity ranges studied. © 2024 CERN.
https://lup.lub.lu.se/record/53357f36-bc89-46e6-b40c-2f701896d950
http://dx.doi.org/10.1103/PhysRevC.109.024915
scopus:85186217652
eng
Physical Review C; 109(2), no 024915 (2024)
ISSN: 2469-9985
Subatomic Physics
Femtoscopic correlations of identical charged pions and kaons in pp collisions at s =13 TeV with event-shape selection
contributiontojournal/article
info:eu-repo/semantics/article
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"Take Up Your Cross" : Public Theology Between Populism and Pluralism in the Post-Migrant Context
https://lup.lub.lu.se/search/publication/5aaf43bf-1637-4d87-b51f-83be36ce6ae9
Schmiedel, Ulrich
2019
As of 1 June 2018, the symbol of the cross has to be shown in all state offices of Bavaria in Germany. In order to chart the churches’ reaction, I return to a conversation that Robert N. Bellah and Martin E. Marty had during the 1960s and the 1970s. Drawing on the core concepts of this conversation, I analyze and assess today’s cross controversy as a case of what I call the ‘populist predicament’. I argue that Marty’s programme of public theology provides a path out of the populist predicament because it combines the celebration and the critique of identity. Ultimately, I advocate for a pluralist position of public theology in the post-migrant context.
https://lup.lub.lu.se/record/5aaf43bf-1637-4d87-b51f-83be36ce6ae9
http://dx.doi.org/10.1163/15697320-12341569
scopus:85069158558
eng
International Journal of Public Theology; 13(2), pp 140-162 (2019)
ISSN: 1872-5171
Religious Studies
"Take Up Your Cross" : Public Theology Between Populism and Pluralism in the Post-Migrant Context
contributiontojournal/article
info:eu-repo/semantics/article
text
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Measurements of inclusive J/ψ production at midrapidity and forward rapidity in Pb–Pb collisions at sNN = 5.02 TeV
https://lup.lub.lu.se/search/publication/819bd7db-ac65-4b24-86db-7c33f51b8a9f
Acharya, S.
Basu, S.
Christiansen, P.
Hansen, J.
Iversen, K.E.
Matonoha, O.
Nassirpour, A.F.
Ohlson, A.
Silvermyr, D.
Staa, J.
Vislavicius, V.
Zurlo, N.
2024
https://lup.lub.lu.se/record/819bd7db-ac65-4b24-86db-7c33f51b8a9f
http://dx.doi.org/10.1016/j.physletb.2024.138451
scopus:85185297531
eng
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics; 849, no 138451 (2024)
ISSN: 0370-2693
Subatomic Physics
Measurements of inclusive J/ψ production at midrapidity and forward rapidity in Pb–Pb collisions at sNN = 5.02 TeV
contributiontojournal/article
info:eu-repo/semantics/article
text
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Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden : a study protocol for a national prospective cohort study
https://lup.lub.lu.se/search/publication/c815fed8-fcfb-491c-bede-7734f5929686
Rasmussen, Mette
Larsson, Matz
Gilljam, Hans
Adami, Johanna
Wärjerstam, Sanne
Post, Ann
Björk-Eriksson, Thomas
Helgason, Asgeir R
Tønnesen, Hanne
2022-01-25
INTRODUCTION: Tobacco is still one of the single most important risk factors among the lifestyle habits that cause morbidity and mortality in humans. Furthermore, tobacco has a heavy social gradient, as the consequences are even worse among disadvantaged and vulnerable groups. To reduce tobacco-related inequity in health, those most in need should be offered the most effective tobacco cessation intervention. The aim of this study is to facilitate and improve the evaluation of already implemented national tobacco cessation efforts, focusing on 10 disadvantaged and vulnerable groups of tobacco users.METHODS AND ANALYSIS: This is a prospective cohort study. Data will be collected by established tobacco cessation counsellors in Sweden. The study includes adult tobacco or e-cigarette users, including disadvantaged and vulnerable patients, receiving in-person interventions for tobacco or e-cigarette cessation (smoking, snus and/or e-cigarettes). Patient inclusion was initiated in April 2020. For data analyses patients will be sorted into vulnerable groups based on risk factors and compared with tobacco users without the risk factor in question.The primary outcome is continuous successful quitting after 6 months, measured by self-reporting. Secondary outcomes include abstinence at the end of the treatment programme, which could be from minutes over days to weeks, 14-day point prevalence after 6 months, and patient satisfaction with the intervention. Effectiveness of successful quitting will be examined by comparing vulnerable with non-vulnerable patients using a mixed-effect logistic regression model adjusting for potential prognostic factors and known confounders.ETHICS AND DISSEMINATION: The project will follow the guidelines from the Swedish Data Protection Authority and have been approved by the Swedish Ethical Review Authority before patient inclusion (Dnr: 2019-02221). Only patients providing written informed consent will be included. Both positive and negative results will be published in scientific peer-reviewed journals and presented at national and international conferences. Information will be provided through media available to the public, politicians, healthcare providers and planners as these are all important stakeholders.TRIAL REGISTRATION NUMBER: NCT04819152.
https://lup.lub.lu.se/record/c815fed8-fcfb-491c-bede-7734f5929686
http://dx.doi.org/10.1136/bmjopen-2021-053090
pmid:35078840
scopus:85123816550
eng
BMJ Open; 12(1), pp 1-7 (2022)
ISSN: 2044-6055
Public Health, Global Health, Social Medicine and Epidemiology
Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden : a study protocol for a national prospective cohort study
contributiontojournal/article
info:eu-repo/semantics/article
text
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Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up
https://lup.lub.lu.se/search/publication/f0b8bc2e-d0e7-492b-a194-0e8257656a26
Fawad, Ayesha
Bergmann, Andreas
Schulte, Janin
Butt, Zahra A
Nilsson, Peter M
Bennet, Louise
Orho-Melander, Marju
Melander, Olle
2022-02-17
CONTEXT: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown.OBJECTIVE: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort.METHODS: In the population-based middle-aged cohort (n = 4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT was assessed and total as well as cause-specific mortality was studied. Main cause of death was based on the International Classification of Diseases.RESULTS: During a mean follow-up of 20 ± 3 years, 950 men and 956 women died. There was significantly increased mortality risk in individuals belonging to the highest quartile (Q) of Pro-NT (Q4, Pro-NT ≥ 149 pmol/L) compared with Qs 1 to 3 (Pro-NT < 149 pmol/L), hazard ratio (HR), 95% CI of 1.29 (1.17-1.42; P < .001). Data were adjusted for sex and age. No significant interaction was observed between Pro-NT and sex on mortality risk. Individuals within Q4 vs Qs 1 to 3 had an HR of 1.41 (95% CI, 1.18-1.68; P < .001) for death due to cardiovascular disease (n = 595/4632); 2.53 (95% CI, 1.37-4.67; P = .003), due to digestive tract disease (n = 42/4632), 1.62 (95% CI, 1.04-2.52; P = .032) due to mental and behavioral disease (n = 90/4632); and 1.91 (95% CI, 1.15-3.19; P = .013) due to unspecific causes (n = 64/4632). There was no significant relationship between Pro-NT and deaths due to cancer, infections, neurological, or other causes. Adjustment for cardiovascular risk factors only marginally changed these results.CONCLUSION: The relationship between Pro-NT and total mortality risk was mainly driven by cardiovascular mortality, but high Pro-NT also predicts death from digestive, mental, and behavioral disease and deaths attributed to unspecific causes.
https://lup.lub.lu.se/record/f0b8bc2e-d0e7-492b-a194-0e8257656a26
http://dx.doi.org/10.1210/clinem/dgab755
pmid:34665860
scopus:85124850874
eng
The Journal of clinical endocrinology and metabolism; 107(3), pp 1204-1211 (2022)
ISSN: 1945-7197
Cardiac and Cardiovascular Systems
Aged
Aged, 80 and over
Cause of Death
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neurotensin/blood
Prospective Studies
Protein Precursors/blood
Risk Assessment/methods
Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up
contributiontojournal/article
info:eu-repo/semantics/article
text
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The Politics of Europeanism : "God" in Ernst Troeltsch's War and Post-War Writings
https://lup.lub.lu.se/search/publication/b20e6341-27fa-4a3b-bc70-98032e82b5ff
Schmiedel, Ulrich
2016
For theologians such as Karl Barth the support for Germany’s militaristic ambitions and actions voiced in the manifesto "An die Kulturwelt", published in 1914, was a consequence of the historicization of theology. Ernst Troeltsch (1865-1923), whose interdisciplinary thinking revolved around the significance of history for theology, was labeled the theologian of historicism. Although he had not signed the manifesto, it continues to throw a smokescreen over Troeltsch’s theology. Examining a selection of both his war writings and his post-war writings, I argue that Troeltsch conceptualized a political theology which led him to turn from a clash of cultures to a conversation of cultures. Troeltsch’s historicization of the concept of God allowed him to resist cultural relativism as well as cultural absolutism. Culminating in the concept of "Europeanism (Europäismus)", Troeltsch’s political theology is instructive for a variety of intra- and inter-cultural conversations in Europe today. But in order to unlock its potential, the smokescreen which the manifesto has thrown over Troeltsch’s theology needs to be lifted.
https://lup.lub.lu.se/record/b20e6341-27fa-4a3b-bc70-98032e82b5ff
http://dx.doi.org/10.1515/znth-2016-0004
eng
Zeitschrift für Neuere Theologiegeschichte / Journal for the History of Modern Theology; 22(2), pp 231-249 (2016)
ISSN: 1612-9776
Religious Studies
The Politics of Europeanism : "God" in Ernst Troeltsch's War and Post-War Writings
contributiontojournal/article
info:eu-repo/semantics/article
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Transcendence - Taxis - Trust : Richard Kearney and Jacques Derrida
https://lup.lub.lu.se/search/publication/995dc6e4-f2ad-4bbe-8204-07a9df7e2993
Schmiedel, Ulrich
2017
Whatever else it takes to drive a taxi, it takes trust. Day after day, the driver has to decide whether the other is or is not trustworthy. I take the taxi as a test case to analyze and assess Richard Kearney’s diacritical hermeneutics of the other. I argue that Kearney functionalizes the concept of transcendence in order to connect the transcendence of the finite other to the transcendence of the infinite other. However, in his central critique of the deconstructionists following Jacques Derrida, Kearney counters his connection. While Kearney’s critique of Derrida’s account of absolute alterity is correct and compelling, I argue that Derrida’s critique of a distinction between the trustworthy other and the non-trustworthy other might be more crucial than Kearney contends. Insisting on openness to the other’s otherness, Derrida provokes any hermeneutic of the other to trust in transcendence. The taxi is taken as a test to illustrate the implications which diacritical and deconstructive drivers might have for evaluating the entanglement of ethics and eschatology—inside and outside the taxi.
https://lup.lub.lu.se/record/995dc6e4-f2ad-4bbe-8204-07a9df7e2993
http://dx.doi.org/10.3390/rel8030037
scopus:85015436816
eng
Religions; 8(3) (2017)
ISSN: 2077-1444
Religious Studies
Transcendence - Taxis - Trust : Richard Kearney and Jacques Derrida
contributiontojournal/article
info:eu-repo/semantics/article
text