Lund University Publications
https://lup.lub.lu.se/search
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2000-01-01T00:00+00:00
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The DIRAC code for relativistic molecular calculations
https://lup.lub.lu.se/search/publication/1dd042c9-1888-4905-a998-2c9879c5e08c
Saue, Trond
Bast, Radovan
Gomes, André Severo Pereira
Jensen, Hans Jørgen Aa
Visscher, Lucas
Aucar, Ignacio Agustín
Di Remigio, Roberto
Dyall, Kenneth G.
Eliav, Ephraim
Fasshauer, Elke
Fleig, Timo
Halbert, Loïc
Hedegård, Erik Donovan
Helmich-Paris, Benjamin
Iliaš, Miroslav
Jacob, Christoph R.
Knecht, Stefan
Laerdahl, Jon K.
Vidal, Marta L.
Nayak, Malaya K.
Olejniczak, Małgorzata
Olsen, Jógvan Magnus Haugaard
Pernpointner, Markus
Senjean, Bruno
Shee, Avijit
Sunaga, Ayaki
van Stralen, Joost N.P.
2020-05-29
DIRAC is a freely distributed general-purpose program system for one-, two-, and four-component relativistic molecular calculations at the level of Hartree-Fock, Kohn-Sham (including range-separated theory), multiconfigurational self-consistent-field, multireference configuration interaction, electron propagator, and various flavors of coupled cluster theory. At the self-consistent-field level, a highly original scheme, based on quaternion algebra, is implemented for the treatment of both spatial and time reversal symmetry. DIRAC features a very general module for the calculation of molecular properties that to a large extent may be defined by the user and further analyzed through a powerful visualization module. It allows for the inclusion of environmental effects through three different classes of increasingly sophisticated embedding approaches: the implicit solvation polarizable continuum model, the explicit polarizable embedding model, and the frozen density embedding model.
https://lup.lub.lu.se/record/1dd042c9-1888-4905-a998-2c9879c5e08c
http://dx.doi.org/10.1063/5.0004844
scopus:85085909114
pmid:32486677
eng
The Journal of chemical physics; 152(20), pp 204104-204104 (2020)
ISSN: 0021-9606
Theoretical Chemistry
The DIRAC code for relativistic molecular calculations
contributiontojournal/article
info:eu-repo/semantics/article
text
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Trimodal low-dose X-ray tomography
https://lup.lub.lu.se/search/publication/485b39d9-dc77-4cc5-96b8-6e6163f14562
Zanette, I.
Bech, M.
Rack, A.
Le Duc, G.
Tafforeau, P.
David, C.
Mohr, J.
Pfeiffer, F.
Weitkamp, T.
2012
X-ray grating interferometry is a coherent imaging technique that bears tremendous potential for three-dimensional tomographic imaging of soft biological tissue and other specimens whose details exhibit very weak absorption contrast. It is intrinsically trimodal, delivering phase contrast, absorption contrast, and scattering ("dark-field") contrast. Recently reported acquisition strategies for grating-interferometric phase tomography constitute a major improvement of dose efficiency and speed. In particular, some of these techniques eliminate the need for scanning of one of the gratings ("phase stepping"). This advantage, however, comes at the cost of other limitations. These can be a loss in spatial resolution, or the inability to fully separate the three imaging modalities. In the present paper we report a data acquisition and processing method that optimizes dose efficiency but does not share the main limitations of other recently reported methods. Although our method still relies on phase stepping, it effectively uses only down to a single detector frame per projection angle and yields images corresponding to all three contrast modalities. In particular, this means that dark-field imaging remains accessible. The method is also compliant with data acquisition over an angular range of only 180° and with a continuous rotation of the specimen.
https://lup.lub.lu.se/record/485b39d9-dc77-4cc5-96b8-6e6163f14562
http://dx.doi.org/10.1073/pnas.1117861109
scopus:84862977187
pmid:22699500
eng
Proceedings of the National Academy of Sciences of the United States of America; 109(26), pp 10199-10204 (2012)
ISSN: 0027-8424
Paleontology
X-ray dark-field imaging
X-ray medical imaging
X-ray microtomography
X-ray phase-contrast imaging
Trimodal low-dose X-ray tomography
contributiontojournal/article
info:eu-repo/semantics/article
text
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Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom
https://lup.lub.lu.se/search/publication/74396380-4dc3-47a4-bddf-57ee601c24e5
Nguyen, Long H.
Joshi, Amit D.
Drew, David A.
Merino, Jordi
Ma, Wenjie
Lo, Chun Han
Kwon, Sohee
Wang, Kai
Graham, Mark S.
Polidori, Lorenzo
Menni, Cristina
Sudre, Carole H.
Anyane-Yeboa, Adjoa
Astley, Christina M.
Warner, Erica T.
Hu, Christina Y.
Selvachandran, Somesh
Davies, Richard
Nash, Denis
Franks, Paul W.
Wolf, Jonathan
Ourselin, Sebastien
Steves, Claire J.
Spector, Tim D.
Chan, Andrew T.
2022
Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteered to take part in the smartphone-based COVID Symptom Study (March 2020-February 2021) and used logistic regression to estimate odds ratios of vaccine hesitancy and uptake. In the U.S. (n = 87,388), compared to white participants, vaccine hesitancy was greater for Black and Hispanic participants and those reporting more than one or other race. In the U.K. (n = 1,254,294), racial and ethnic minority participants showed similar levels of vaccine hesitancy to the U.S. However, associations between participant race and ethnicity and levels of vaccine uptake were observed to be different in the U.S. and the U.K. studies. Among U.S. participants, vaccine uptake was significantly lower among Black participants, which persisted among participants that self-reported being vaccine-willing. In contrast, statistically significant racial and ethnic disparities in vaccine uptake were not observed in the U.K sample. In this study of self-reported vaccine hesitancy and uptake, lower levels of vaccine uptake in Black participants in the U.S. during the initial vaccine rollout may be attributable to both hesitancy and disparities in access.
https://lup.lub.lu.se/record/74396380-4dc3-47a4-bddf-57ee601c24e5
http://dx.doi.org/10.1038/s41467-022-28200-3
scopus:85124058662
pmid:35105869
eng
Nature Communications; 13(1), no 636 (2022)
ISSN: 2041-1723
Public Health, Global Health, Social Medicine and Epidemiology
Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom
contributiontojournal/article
info:eu-repo/semantics/article
text
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The role of mechanical ventilation in primary graft dysfunction in the postoperative lung transplant recipient : A single center study and literature review
https://lup.lub.lu.se/search/publication/170e36f2-9b80-4737-a01b-0be87cf5a62a
Niroomand, Anna
Qvarnström, Sara
Stenlo, Martin
Malmsjö, Malin
Ingemansson, Richard
Hyllén, Snejana
Lindstedt, Sandra
2022-04
Background: Primary graft dysfunction (PGD) is still a major complication in patients undergoing lung transplantation (LTx). Much is unknown about the effect of postoperative mechanical ventilation on outcomes, with debate on the best approach to ventilation. Aim/Purpose: The goal of this study was to generate hypotheses on the association between postoperative mechanical ventilation settings and allograft size matching in PGD development. Method: This is a retrospective study of LTx patients between September 2011 and September 2018 (n = 116). PGD was assessed according to the International Society of Heart and Lung Transplantation (ISHLT) criteria. Data were collected from medical records, including chest x-ray assessments, blood gas analysis, mechanical ventilator parameters and spirometry. Results: Positive end-expiratory pressures (PEEP) of 5 cm H2O were correlated with lower rates of grade 3 PGD. Graft size was important as tidal volumes calculated according to the recipient yielded greater rates of PGD when low volumes were used, a correlation that was lost when donor metrics were used. Conclusion: Our results highlight a need for greater investigation of the role donor characteristics play in determining post-operative ventilation of a lung transplant recipient. The mechanical ventilation settings on postoperative LTx recipients may have an implication for the development of acute graft dysfunction. Severe PGD was associated with the use of a PEEP higher than 5 and lower tidal volumes and oversized lungs were associated with lower long-term mortality. Lack of association between ventilatory settings and survival may point to the importance of other variables than ventilation in the development of PGD.
https://lup.lub.lu.se/record/170e36f2-9b80-4737-a01b-0be87cf5a62a
http://dx.doi.org/10.1111/aas.14025
scopus:85123684727
pmid:35014027
eng
Acta Anaesthesiologica Scandinavica; 66(4), pp 483-496 (2022)
ISSN: 0001-5172
Anesthesiology and Intensive Care
lung transplant recipients
postoperative mechanical ventilation
primary graft dysfunction
protective lung ventilation
The role of mechanical ventilation in primary graft dysfunction in the postoperative lung transplant recipient : A single center study and literature review
contributiontojournal/article
info:eu-repo/semantics/article
text
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Favorable fatty acid composition in adipose tissue in healthy Iraqi- compared to Swedish-born men - a pilot study using MRI assessment
https://lup.lub.lu.se/search/publication/0d5cec41-87c7-46db-b4e3-5196366161ca
Trinh, Lena
Stenkula, Karin G
Olsson, Lars E
Svensson, Jonas
Peterson, Pernilla
Bennet, Louise
Månsson, Sven
2022
Middle Eastern immigrants are at high-risk for insulin resistance. Fatty acid composition (FAC) plays an important role in the development of insulin resistance but has not been investigated in people of Middle Eastern ancestry. Here, the aim was to assess the FAC in visceral and subcutaneous adipose tissue (VAT and SAT) in healthy Iraqi- and Swedish-born men using a magnetic resonance imaging (MRI) method.This case-control study included 23 Iraqi- and 15 Swedish-born middle-aged men, without cardiometabolic disease. Using multi-echo MRI of the abdomen, the fractions of saturated, monounsaturated, and polyunsaturated fatty acids (fSFA, fMUFA, and fPUFA) were estimated in VAT and SAT. SAT was further analyzed in deep and superficial compartments (dSAT and sSAT).In all depots, fPUFA was significantly higher and fSFA significantly lower in Iraqi men, independently of age and BMI. In both Iraqi- and Swedish-born men, higher fPUFA and lower fMUFA were found in sSAT vs. dSAT. Among Iraqi men only, higher fPUFA and lower fMUFA were found in SAT vs. VAT.Iraqi-born men presented a more favorable abdominal FAC compared to Swedish-born men. This MRI method also revealed different FACs in different abdominal depots. Our results may reflect a beneficial FAC in Middle Eastern immigrants.
https://lup.lub.lu.se/record/0d5cec41-87c7-46db-b4e3-5196366161ca
http://dx.doi.org/10.1080/21623945.2022.2042963
pmid:35291924
scopus:85126645589
eng
Adipocyte; 11(1), pp 153-163 (2022)
ISSN: 2162-3945
Endocrinology and Diabetes
Public Health, Global Health, Social Medicine and Epidemiology
Favorable fatty acid composition in adipose tissue in healthy Iraqi- compared to Swedish-born men - a pilot study using MRI assessment
contributiontojournal/article
info:eu-repo/semantics/article
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Sketching a philosophy of entrepreneurship
https://lup.lub.lu.se/search/publication/40603947-3134-40f7-a40c-6aee12a88e97
Baker, Ted
Welter, Friederike
Hjorth, Daniel
2014
What does it mean to approach the task of sketching a philosophy of entrepreneurship as if such a philosophy is needed and doable? At a minimum it would need to mean that such a task is inscribed in a genealogy of pursuits that lend to it a shimmer of legitimacy and potentiality. Previous efforts, similar in kind, suggest that attending to the philosophical issues that are immanent to the what-and how-questions and problems dealt with within a particular ‘discipline’ represents an important learning per se. We thus have philosophies of management (a journal published by Libri Publishing; books, e.g. Sheldon and Thompson 2003; conferences in 2012 organized by St Anne’s College in Oxford), philosophies of organization (Koslowski 2010; Krijnen and Kee 2009; Spoelstra 2007) and of leadership (a topic that includes Socratic parrhesia; Augustinian Confessions; Machiavelli’s The Prince; as well as recent and much more instrumental guides to how to motivate your employees). In addition, we have philosophy and books, such as Philosophy and Organization (Jones and ten Bos 2007).
https://lup.lub.lu.se/record/40603947-3134-40f7-a40c-6aee12a88e97
ISBN: 9781138363182
ISBN: 9780415631761
ISBN: 9781136218620
scopus:84940194576
eng
Business Administration
Sketching a philosophy of entrepreneurship
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
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Entrepreneuring as organisation-creation
https://lup.lub.lu.se/search/publication/4fdd0b39-a870-4a1a-bc39-b039f78bd45c
Sternberg, Rolf
Krauss, Gerhard
Hjorth, Daniel
2014
This chapter aims at making a contribution to the study of entrepreneurship and creativity by developing a processual conceptualisation of a form of entrepreneurial creativity called entrepreneuring or organisation-creation. Such a processual conceptualisation of entrepreneuring will answer the long-standing call in entrepreneurship research for an enhanced capacity to study organisation-in-creation. I believe recent advances in process thinking, in organisation studies have provided us, finally, with such ‘changes in our perceptions and methodologies’, meaning we have now a capacity to step up to this challenge. This chapter attempts to make one contribution.
https://lup.lub.lu.se/record/4fdd0b39-a870-4a1a-bc39-b039f78bd45c
http://dx.doi.org/10.4337/9781781004432.00011
ISBN: 9781781004425
ISBN: 9781781004432
scopus:84924917567
eng
Business Administration
Entrepreneuring as organisation-creation
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text
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Mitochondrial function in peripheral blood cells across the human lifespan
https://lup.lub.lu.se/search/publication/8773f9bd-6936-4ae9-a806-1a4f3a33df32
Ehinger, Johannes K.
Westerlund, Emil
Frostner, Eleonor Åsander
Karlsson, Michael
Paul, Gesine
Sjövall, Fredrik
Elmér, Eskil
2024-12
Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs. These results add to the understanding of mitochondrial dysfunction in aging and to its possible role in immune cell and platelet senescence.
https://lup.lub.lu.se/record/8773f9bd-6936-4ae9-a806-1a4f3a33df32
http://dx.doi.org/10.1038/s41514-023-00130-4
scopus:85184924260
pmid:38326348
eng
npj Aging; 10(1), no 10 (2024)
ISSN: 2731-6068
Immunology in the medical area
Mitochondrial function in peripheral blood cells across the human lifespan
contributiontojournal/article
info:eu-repo/semantics/article
text
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Playing
https://lup.lub.lu.se/search/publication/419e9ae5-0360-4555-ade7-d2a40a52491a
Mikko, Vesa
Hjorth, Daniel
2021-02-25
https://lup.lub.lu.se/record/419e9ae5-0360-4555-ade7-d2a40a52491a
ISBN: 9780429316722
ISBN: 9780367321185
scopus:85106091360
eng
Business Administration
Playing
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
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Breastfeeding among parous women offered home-visit by a midwife after early discharge following planned cesarean section : Secondary analysis of a randomized controlled trial
https://lup.lub.lu.se/search/publication/cd98013b-0a6c-41fe-9008-6582866efb59
Kruse, Anne R.
Lauszus, Finn F.
Forman, Axel
Kesmodel, Ulrik S.
Rugaard, Marie B.
Knudsen, Randi K.
Persson, Eva Kristina
Sundtoft, Iben B.
Uldbjerg, Niels
2023
INTRODUCTION Early discharge holds several advantages and seems safe after planned cesarean section among low-risk women. However, breastfeeding rates are lower after cesarean section. Thus, concern has been raised that early discharge among these women may affect breastfeeding even further. Therefore, we aimed to assess the effect of early discharge the day after planned cesarean section on breastfeeding, among parous women when a home-visit by a midwife was provided the day after discharge. METHODS We conducted a secondary analysis of a randomized trial. Parous women (n=143) planned for cesarean section were allocated to either discharge within 28 hours after planned cesarean section followed by a home visit the day after (early discharge) or discharge at least 48 hours after planned cesarean section (standard care). The participants filled in questionnaires approximately 2 weeks before delivery and 1 week, 4 weeks, and 6 months postpartum. RESULTS The proportions of women initiating breastfeeding were 84% versus 87% (early discharge vs standard care). After 6 months, 23% versus 21% were exclusively breastfeeding, while 29% versus 42% were partially breastfeeding. The mean duration of exclusive breastfeeding was 3.4 months (SD=2.3) in both groups. None of these differences was statistically significant. In both groups, the women’s breastfeeding selfefficacy score before cesarean section correlated with the duration of breastfeeding. After 4 weeks, low-score rates were 28% versus 30%. CONCLUSIONS Early discharge with follow-up home visits by a midwife after planned cesarean section in parous women is feasible without compromising breastfeeding.
https://lup.lub.lu.se/record/cd98013b-0a6c-41fe-9008-6582866efb59
http://dx.doi.org/10.18332/ejm/173089
scopus:85184268778
pmid:38075381
eng
European Journal of Midwifery; 7(December), no 38 (2023)
ISSN: 2585-2906
Nursing
breastfeeding
cesarean section
house calls
length of stay
postnatal care
self-efficacy
Breastfeeding among parous women offered home-visit by a midwife after early discharge following planned cesarean section : Secondary analysis of a randomized controlled trial
contributiontojournal/article
info:eu-repo/semantics/article
text
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PON-Sol2 : Prediction of effects of variants on protein solubility
https://lup.lub.lu.se/search/publication/ba875afa-1663-4a9c-9641-3b0190a22280
Yang, Yang
Zeng, Lianjie
Vihinen, Mauno
2021-08-01
Genetic variations have a multitude of effects on proteins. A substantial number of variations affect protein–solvent interactions, either aggregation or solubility. Aggregation is often related to structural alterations, whereas solubilizable proteins in the solid phase can be made again soluble by dilution. Solubility is a central protein property and when reduced can lead to diseases. We developed a prediction method, PON-Sol2, to identify amino acid substitutions that increase, decrease, or have no effect on the protein solubility. The method is a machine learning tool utilizing gradient boosting algorithm and was trained on a large dataset of variants with different outcomes after the selection of features among a large number of tested properties. The method is fast and has high performance. The normalized correct prediction rate for three states is 0.656, and the normalized GC2 score is 0.312 in 10-fold cross-validation. The corresponding numbers in the blind test were 0.545 and 0.157. The performance was superior in comparison to previous methods. The PON-Sol2 predictor is freely available. It can be used to predict the solubility effects of variants for any organism, even in large-scale projects.
https://lup.lub.lu.se/record/ba875afa-1663-4a9c-9641-3b0190a22280
http://dx.doi.org/10.3390/ijms22158027
scopus:85111125476
pmid:34360790
eng
International Journal of Molecular Sciences; 22(15), no 8027 (2021)
ISSN: 1661-6596
Medical Genetics
Artificial intelligence
Machine learning
Mutation
PON-Sol2
Prediction
Protein solubility prediction
Variation
Variation interpretation
PON-Sol2 : Prediction of effects of variants on protein solubility
contributiontojournal/article
info:eu-repo/semantics/article
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Cultural adaptation and psychometric properties of the spanish version of the occupational balance questionnaire : An instrument for occupation-based research
https://lup.lub.lu.se/search/publication/2dbcd8c0-5df3-4c2a-9cb2-c2b15d9b01ea
Peral-Gómez, Paula
López-Roig, Sofía
Pastor-Mira, María Ángeles
Abad-Navarro, Ester
Valera-Gran, Desirée
Håkansson, Carita
Wagman, Petra
2021-07-02
Occupational balance (OB) may be a major determinant of health outcomes due to its role in bringing a sense of purpose in the occupations that are personally experienced as a process of getting health and wellness. The Occupational Balance Questionnaire (OBQ) is a reliable instrument for measuring OB, although it has not been adapted and validated in Spain so far; therefore, this study had a double aim: (1) to translate and cross-culturally adapt the original OBQ version into Spanish (OBQ-E); (2) to analyze the psychometric properties for its use in the Spanish population. Standard procedures were used for the cross-adaptation process and pilot testing was carried out using three different samples to extend the applicability of the OBQ-E. Validation measures of the final version of the OBQ-E were conducted in a sample of 219 participants. The OBQ-E showed that items and instructions were culturally appropriate and written clearly. Psychometric testing showed excellent internal consistency (Cronbach’s alpha = 0.87; Guttman split-half coefficient = 0.85), good test–retest reliability (rs (Spearman rho) = 0.73), and acceptable convergent validity (overall status, rs = 0.37; Related Quality of Life, rs = 0.42; Satisfaction with Life Scale, rs = 0.54). The findings suggest that the OBQ-E may be a suitable instrument for assessing OB in the Spanish population; hence, it is a promising tool for epidemiological research that will significantly contribute to the understanding of OB as a health-related factor. Nevertheless, further investigation is also warranted to explore the potentiality of this instrument for clinical purposes.
https://lup.lub.lu.se/record/2dbcd8c0-5df3-4c2a-9cb2-c2b15d9b01ea
http://dx.doi.org/10.3390/ijerph18147506
scopus:85109827218
pmid:34299957
eng
International Journal of Environmental Research and Public Health; 18(14), no 7506 (2021)
ISSN: 1661-7827
Occupational Therapy
Adaptation
Occupational balance
Psychometric testing
Questionnaire
Validation
Cultural adaptation and psychometric properties of the spanish version of the occupational balance questionnaire : An instrument for occupation-based research
contributiontojournal/article
info:eu-repo/semantics/article
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No apparent increase in treatment uptake for gambling disorder during ten months of the covid-19 pandemic—analysis of a regional specialized treatment unit in Sweden
https://lup.lub.lu.se/search/publication/8d200dee-3301-4321-99de-3f1009fe0806
Håkansson, Anders
Åkesson, Gunny
Grudet, Cécile
Broman, Niroshani
2021-02-02
The COVID-19 pandemic and its impact on society has been suspected to affect gambling behaviors. Potentially, the pandemic crisis may result in increased problem gambling, for example, due to COVID-19-related psychological distress, unemployment, and financial difficulties. In ad-dition, the cancellation of sports in early parts of the crisis has been suspected to alter gambling behaviors. Policy makers have called for action and, in some cases, have changed regulations, and media have reported possible increases in treatment seeking. However, research data are hitherto lacking. The present study assessed the treatment uptake at a regional specialized gambling-disorder unit in the healthcare system of Region Skåne, Sweden. Number of patients, treatment contacts, and patterns of rescheduling or cancellations of appointments were quantified for each month, January– December 2020, and compared to corresponding months of 2018 and 2019. Possible trends were analyzed, using an interrupted time-series analysis. Results did not indicate an increase in treatment uptake for gambling disorder during the months of COVID-19 impact in Sweden. The proportion of digital treatment increased, but total treatment uptake was unaffected by the pandemic. In conclusion, during the first ten months of the pandemic in Sweden, no obvious increase in treatment uptake for gambling disorder could be seen. Moreover, longer follow-up may be necessary in order to see if effects of worsening socioeconomic conditions may be a possible long-term risk factor of increased gambling after COVID-19.
https://lup.lub.lu.se/record/8d200dee-3301-4321-99de-3f1009fe0806
http://dx.doi.org/10.3390/ijerph18041918
scopus:85101159553
pmid:33671210
eng
International Journal of Environmental Research and Public Health; 18(4), pp 1-10 (2021)
ISSN: 1661-7827
Public Health, Global Health, Social Medicine and Epidemiology
COVID-19
Gambling disorder
Pandemic
Problem gambling
Treatment seeking
No apparent increase in treatment uptake for gambling disorder during ten months of the covid-19 pandemic—analysis of a regional specialized treatment unit in Sweden
contributiontojournal/article
info:eu-repo/semantics/article
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Perceived opportunities for physical activity and willingness to be more active in older adults with different physical activity levels
https://lup.lub.lu.se/search/publication/1bb4be8b-713f-45e9-b1e4-1aede824d126
Aartolahti, Eeva
Eronen, Johanna
Törmäkangas, Timo
Rantanen, Taina
Hirvensalo, Mirja
Palmberg, Lotta
Skantz, Heidi
Viljanen, Anne
Portegijs, Erja
Iwarsson, Susanne
Rantakokko, Merja
2021-06-01
This study examined equity in physical activity (PA) by investigating whether perceived opportunity for PA was associated with willingness to be more active. Among community residents (75, 80, or 85 years old, n = 962) perceived opportunity for PA (poor and good), willingness to be more active (not at all, a bit, and a lot), and level of PA (low, moderate, and high) were assessed via questionnaires. Multinomial logistic regression showed that physical activity moderated the association between poor opportunity and willingness to increase PA. Among those with moderate PA, poor opportunity for PA increased the odds of willingness to be a lot more active (multinomial odds ratio, mOR 3.90, 95% confidence interval 2.21–6.87) than not wanting to be more active compared to those perceiving good opportunities. Associations were similar at high PA levels (p < 0.001), but were not found at low PA levels. Those with moderate or high PA wish to increase their activity particularly when the perceived opportunities for activity are not optimal. Among those with low PA, perceived opportunities are not associated with a perceived need to increase physical activity. Increasing equity in physical activity in old age requires provision of support and opportunities at every level of physical activity.
https://lup.lub.lu.se/record/1bb4be8b-713f-45e9-b1e4-1aede824d126
http://dx.doi.org/10.3390/ijerph18116146
scopus:85107398723
pmid:34200182
eng
International Journal of Environmental Research and Public Health; 18(11), no 6146 (2021)
ISSN: 1661-7827
Public Health, Global Health, Social Medicine and Epidemiology
Aging
Equity
Exercise
Physical function
Unmet need
Perceived opportunities for physical activity and willingness to be more active in older adults with different physical activity levels
contributiontojournal/article
info:eu-repo/semantics/article
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Do Drug Accessibility and OOP Burden Affect Health-Related Quality of Life of Patients With Chronic Diseases? — EQ-5D-5L Evaluation Evidence From Five Districts in China
https://lup.lub.lu.se/search/publication/a527d3a4-5b15-4e76-8ae5-e518343fbe95
Tang, Shaoliang
Gong, Ying
Liu, Meixian
Yang, Duoer
Tang, Kean
2021-03-12
Purpose: The dependence of patients with chronic diseases on drugs may affect their health-related quality of life (HRQoL). This study aims to assess the relationship between the direct economic burden caused by out-of-pocket (OOP) payments, drug accessibility, sociodemographic characteristics, and health-related quality of life. Methods: 1,055 patients with chronic diseases from Gansu, Hebei, Sichuan, Zhejiang, and Tianjin were investigated. Data collection included basic conditions and economic and health insurance conditions of patients with chronic diseases. The CLAD and Tobit regression models were used to analyze and compare the health-related quality of life and influencing factors of patients with chronic diseases in five districts. Differentiated analysis was conducted through sub-sample regression to explore the variable health effects of patients with single and multiple diseases. Results: A total of 1,055 patients with chronic diseases participated in the study, 54.4% of whom were women. The overall average utility score was 0.727, of which Sichuan Province was the highest with 0.751. Participants reported the highest proportion of pain/discomfort problems, while patients reported the least problems with self-care. The improvement of drug accessibility and the reduction of the burden of out-of-pocket expenses have significant positive effects on HRQoL. Various sociodemographic factors such as age and gender also have significant impact on HRQoL of patients with chronic diseases. HRQoL of patients with multiple chronic diseases is more affected by various influencing factors than that of patients with single disease. Conclusion: In order to improve the quality of life of patients with chronic diseases, it is of great importance to ensure the accessibility of drugs and reduce patients' medication burden. Future focus should shift from preventing and controlling chronic diseases as individual diseases to meeting the comprehensive health needs of people suffering from multiple diseases.
https://lup.lub.lu.se/record/a527d3a4-5b15-4e76-8ae5-e518343fbe95
http://dx.doi.org/10.3389/fpubh.2021.656104
scopus:85103325042
pmid:33791272
eng
Frontiers in Public Health; 9, no 656104 (2021)
ISSN: 2296-2565
Health Care Service and Management, Health Policy and Services and Health Economy
CLAD model
drug accessibility
health-related quality of life
OOP
patients with chronic diseases
Do Drug Accessibility and OOP Burden Affect Health-Related Quality of Life of Patients With Chronic Diseases? — EQ-5D-5L Evaluation Evidence From Five Districts in China
contributiontojournal/article
info:eu-repo/semantics/article
text
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Pre-asthma : a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma
https://lup.lub.lu.se/search/publication/89c55b0a-2860-4bff-97c3-f915e441936f
Scadding, G. K.
McDonald, M.
Backer, V.
Scadding, G.
Bernal-Sprekelsen, M.
Conti, D. M.
De Corso, E.
Diamant, Z.
Gray, C.
Hopkins, C.
Jesenak, M.
Johansen, P.
Kappen, J.
Mullol, J.
Price, D.
Quirce, S.
Reitsma, S.
Salmi, S.
Senior, B.
Thyssen, J. P.
Wahn, U.
Hellings, P. W.
2023
Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society. It is the most common chronic disease in children and represents one of the major causes for years lived with disability. Significant efforts are made by organizations such as WHO in improving the diagnosis, treatment and monitoring of asthma. However asthma prevention has been less studied. Currently there is a concept of pre- diabetes which allows a reduction in full blown diabetes if diet and exercise are undertaken. Similar predictive states are found in Alzheimer's and Parkinson's diseases. In this paper we explore the possibilities for asthma prevention, both at population level and also investigate the possibility of defining a state of pre-asthma, in which intensive treatment could reduce progression to asthma. Since asthma is a heterogeneous condition, this paper is concerned with allergic asthma. A subsequent one will deal with late onset eosinophilic asthma.
https://lup.lub.lu.se/record/89c55b0a-2860-4bff-97c3-f915e441936f
http://dx.doi.org/10.3389/falgy.2023.1291185
scopus:85184725138
pmid:38352244
eng
Frontiers in Allergy; 4, no 1291185 (2023)
ISSN: 2673-6101
Respiratory Medicine and Allergy
asthma
asthma natural history
pre-asthma
predisposition
quality of life
risk factors
Pre-asthma : a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma
contributiontojournal/systematicreview
info:eu-repo/semantics/article
text
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State-Space Gaussian Process for Drift Estimation in Stochastic Differential Equations
https://lup.lub.lu.se/search/publication/178f072e-99a3-4704-bb9b-6009bf73ac4c
Zhao, Zheng
Tronarp, Filip
Särkkä, Simo
Hostettler, Roland
2020
This paper is concerned with the estimation of unknown drift functions of stochastic differential equations (SDEs) from observations of their sample paths. We propose to formulate this as a non-parametric Gaussian process regression problem and use an Ito-Taylor expansion for approximating the SDE. To address the computational complexity problem of Gaussian process regression, we cast the model in an equivalent state-space representation, such that (non-linear) Kalman filters and smoothers can be used. The benefit of these methods is that computational complexity scales linearly with respect to the number of measurements and hence the method remains tractable also with large amounts of data. The overall complexity of the proposed method is O(N log N), where N is the number of measurements, due to the requirement of sorting the input data. We evaluate the performance of the proposed method using simulated data as well as with real-data applications to sunspot activity and electromyography.
https://lup.lub.lu.se/record/178f072e-99a3-4704-bb9b-6009bf73ac4c
http://dx.doi.org/10.1109/ICASSP40776.2020.9054472
ISBN: 978-1-5090-6631-5
ISBN: 978-1-5090-6632-2
scopus:85091179111
eng
Probability Theory and Statistics
State-Space Gaussian Process for Drift Estimation in Stochastic Differential Equations
contributiontobookanthology/conference
info:eu-repo/semantics/conferencePaper
text
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Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer
https://lup.lub.lu.se/search/publication/41c5119a-2ca5-43ad-9b8e-93294e8dbcae
Uno, Kaname
Koya, Yoshihiro
Yoshihara, Masato
Iyoshi, Shohei
Kitami, Kazuhisa
Sugiyama, Mai
Miyamoto, Emiri
Mogi, Kazumasa
Fujimoto, Hiroki
Yamakita, Yoshihiko
Wang, Xinhui
Nawa, Akihiro
Kajiyama, Hiroaki
2024-02
Most epithelial ovarian cancer (EOC) patients are diagnosed with peritoneal dissemination. Cellular interactions are an important aspect of EOC cells when they detach from the primary site of the ovary. However, the mechanism remains underexplored. Our study aimed to reveal the role of chondroitin sulfate proteoglycan 4 (CSPG4) in EOC with a major focus on cell–cell interactions. We examined the expression of CSPG4 in clinical samples and cell lines of EOC. The proliferation, migration, and invasion abilities of the CSPG4 knockdown cells were assessed. We also assessed the role of CSPG4 in spheroid formation and peritoneal metastasis in an in vivo model using sh-CSPG4 EOC cell lines. Of the clinical samples, 23 (44.2%) samples expressed CSPG4. CSPG4 was associated with a worse prognosis in patients with advanced EOC. Among the EOC cell lines, aggressive cell lines, including ES2, expressed CSPG4. When CSPG4 was knocked down using siRNA or shRNA, the cell proliferation, migration, and invasion abilities were significantly decreased compared to the control cells. Proteomic analyses showed changes in the expression of proteins related to the cell movement pathways. Spheroid formation was significantly inhibited when CSPG4 was inhibited. The number of nodules and the tumor burden of the omentum were significantly decreased in the sh-CSPG4 mouse models. In the peritoneal wash fluid from mice injected with sh-CSPG4 EOC cells, significantly fewer spheroids were present. Reduced CSPG4 expression was observed in lymphoid enhancer-binding factor 1-inhibited cells. CSPG4 is associated with aggressive features of EOC and poor prognosis. CSPG4 could be a new treatment target for blocking peritoneal metastasis by inhibiting spheroid formation.
https://lup.lub.lu.se/record/41c5119a-2ca5-43ad-9b8e-93294e8dbcae
http://dx.doi.org/10.3390/ijms25031626
scopus:85184730999
pmid:38338902
eng
International Journal of Molecular Sciences; 25(3), no 1626 (2024)
ISSN: 1661-6596
Cell and Molecular Biology
cancer spheroids
cell–cell interaction
chondroitin sulfate
ovarian cancer
peritoneal metastasis
Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer
contributiontojournal/article
info:eu-repo/semantics/article
text
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Novel biomarkers for epithelial ovarian cancer detection and assessing future cancer risk in women with borderline ovarian tumors
https://lup.lub.lu.se/search/publication/ce836440-6806-4dba-a1c3-17bd0bbab4a5
Dobilas, Arturas
2023
application/pdf
https://lup.lub.lu.se/record/ce836440-6806-4dba-a1c3-17bd0bbab4a5
urn:isbn:978-91-8021-462-9
https://lup.lub.lu.se/search/files/159587678/Avhandling_Arturas_Dobilas_utan_papers.pdf
eng
info:eu-repo/semantics/openAccess
Lund University, Faculty of Medicine Doctoral Dissertation Series; (2023:121) (2023)
ISSN: 1652-8220
Obstetrics, Gynecology and Reproductive Medicine
Ovarian cancer and Biomarkers
Novel biomarkers for epithelial ovarian cancer detection and assessing future cancer risk in women with borderline ovarian tumors
thesis/doccomp
info:eu-repo/semantics/doctoralThesis
text
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Patient-reported outcomes and preferences for colon capsule endoscopy and colonoscopy : A systematic review with meta-analysis
https://lup.lub.lu.se/search/publication/2b6386ec-1118-4a5e-bc20-1444ff7f3f87
Deding, Ulrik
Valdivia, Pablo Cortegoso
Koulaouzidis, Anastasios
Baatrup, Gunnar
Toth, Ervin
Spada, Cristiano
Fernández-Urién, Ignacio
Pennazio, Marco
Bjørsum-Meyer, Thomas
2021-09
Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in-and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including univariate meta-regressions. Patient-reported tolerability and adverse events were reviewed. Out of fourteen included studies, twelve had investigated patient-reported outcomes in patients who had undergone both investigations, whereas in two the patients were randomized between investigations. Pooled patient preferences were estimated to be 52% (CI 95%: 41–63%) for colon capsule endoscopy and 45% (CI 95%: 33–57%) for conventional colonoscopy: not indicating a significant difference. Procedural adverse events were rarely reported by patients for either investigation. The tolerability was high for both colon capsule endoscopy and conventional colonoscopy. Patient preferences for conventional colonoscopy and colon capsule endoscopy were not significantly different. Procedural adverse events were rare and the tolerability for colon capsule endoscopy was consistently reported higher or equal to that of conventional colonoscopy.
https://lup.lub.lu.se/record/2b6386ec-1118-4a5e-bc20-1444ff7f3f87
http://dx.doi.org/10.3390/diagnostics11091730
pmid:34574071
scopus:85116594175
eng
Diagnostics; 11(9), no 1730 (2021)
ISSN: 2075-4418
Gastroenterology and Hepatology
Colon capsule endoscopy
Colonoscopy
Endoscopy
Patient-reported outcomes
Patient-reported outcomes and preferences for colon capsule endoscopy and colonoscopy : A systematic review with meta-analysis
contributiontojournal/systematicreview
info:eu-repo/semantics/article
text
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Association of excessive daytime sleepiness with the zung self-rated depression subscales in adults with coronary artery disease and obstructive sleep apnea
https://lup.lub.lu.se/search/publication/dfe3b658-c107-4dd0-990b-cd715c31f533
Celik, Yeliz
Yapici-Eser, Hale
Balcan, Baran
Peker, Yüksel
2021-07
Excessive daytime sleepiness (EDS) is a factor associated with both obstructive sleep apnea (OSA) and depressive symptoms. Continuous positive airway pressure (CPAP) treatment may decrease EDS in adults with OSA; however, the modulatory role of depressive symptoms on the improvement of EDS is not known. We aimed to explore the association between subscales of the Zung Self-rated Depression Scale (SDS) and Epworth Sleepiness Scale (ESS) over a 2-year period in coronary artery disease (CAD) patients with OSA. This was a post-hoc analysis of the RICCADSA cohort, in which 399 adults with CAD (155 sleepy OSA [apnea–hypopnea index ≥ 15/h] and ESS score ≥ 10, who were offered CPAP; and 244 nonsleepy OSA [ESS < 10]), randomized to CPAP [n = 122] or no-CPAP [n = 122]) were included. Three factors were extracted from the Zung SDS, based on the principal component analysis: F1, cognitive symptoms and anhedonia; F2, negative mood; and F3, appetite. In a mixed model, the ESS score decreased by 3.4 points (p < 0.001) among the sleepy OSA phenotype, which was predicted by the decline in the F2, but not in the F1 and F3 scores. The fixed effects of time were not significant in the nonsleepy OSA groups, and thus, further analyses were not applicable. Additional within-group analyses showed a significant decrease in all subscales over time both in the sleepy and nonsleepy OSA patients on CPAP whereas there was a significant increase in the nonsleepy OSA group randomized to no-CPAP. We conclude that the improvement in negative mood symptoms of depression, but not changes in cognitive symptoms and anhedonia as well as appetite, was a significant predictor of decline in the ESS scores over a 2-year period in this CAD cohort with sleepy OSA on CPAP treatment.
https://lup.lub.lu.se/record/dfe3b658-c107-4dd0-990b-cd715c31f533
http://dx.doi.org/10.3390/diagnostics11071176
pmid:34203553
scopus:85110045543
eng
Diagnostics; 11(7), no 1176 (2021)
ISSN: 2075-4418
Respiratory Medicine and Allergy
Cardiac and Cardiovascular Systems
Coronary artery disease
Depression
Excessive daytime sleepiness
Obstructive sleep apnea
Zung SDS
Association of excessive daytime sleepiness with the zung self-rated depression subscales in adults with coronary artery disease and obstructive sleep apnea
contributiontojournal/article
info:eu-repo/semantics/article
text
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Unraveling human aqp5-pip molecular interaction and effect on aqp5 salivary glands localization in ss patients
https://lup.lub.lu.se/search/publication/c757bbca-50a0-4624-b1c4-6392fbf44368
Chivasso, Clara
Nesverova, Veronika
Järvå, Michael
Blanchard, Anne
Rose, Kristie L.
Öberg, Fredrik Kryh
Wang, Zhen
Martin, Maud
Lhotellerie, Florent
Zindy, Egor
Junqueira, Bruna
Leroy, Karelle
Vanhollebeke, Benoit
Delforge, Valérie
Bolaky, Nargis
Perret, Jason
Soyfoo, Muhammad Shahnawaz
Moscato, Stefania
Baldini, Chiara
Chaumont, François
Mattii, Letizia
Schey, Kevin L.
Myal, Yvonne
Törnroth-Horsefield, Susanna
Delporte, Christine
2021-08
Saliva secretion requires effective translocation of aquaporin 5 (AQP5) water channel to the salivary glands (SGs) acinar apical membrane. Patients with Sjögren’s syndrome (SS) display abnormal AQP5 localization within acinar cells from SGs that correlate with sicca manifestation and glands hypofunction. Several proteins such as Prolactin-inducible protein (PIP) may regulate AQP5 trafficking as observed in lacrimal glands from mice. However, the role of the AQP5-PIP complex remains poorly understood. In the present study, we show that PIP interacts with AQP5 in vitro and in mice as well as in human SGs and that PIP misexpression correlates with an altered AQP5 distribution at the acinar apical membrane in PIP knockout mice and SS hMSG. Furthermore, our data show that the protein-protein interaction involves the AQP5 C-terminus and the N-terminal of PIP (one molecule of PIP per AQP5 tetramer). In conclusion, our findings highlight for the first time the role of PIP as a protein controlling AQP5 localization in human salivary glands but extend beyond due to the PIP-AQP5 interaction described in lung and breast cancers.
https://lup.lub.lu.se/record/c757bbca-50a0-4624-b1c4-6392fbf44368
http://dx.doi.org/10.3390/cells10082108
pmid:34440877
scopus:85113491858
eng
Cells; 10(8), no 2108 (2021)
ISSN: 2073-4409
Cell and Molecular Biology
Rheumatology and Autoimmunity
Aquaporin-5
Prolactin-inducible protein
Salivary gland
Sjögren’s syndrome
Unraveling human aqp5-pip molecular interaction and effect on aqp5 salivary glands localization in ss patients
contributiontojournal/article
info:eu-repo/semantics/article
text
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Self-Transcendence as a Buffer Against COVID-19 Suffering : The Development and Validation of the Self-Transcendence Measure-B
https://lup.lub.lu.se/search/publication/a580ec11-187d-4eba-9460-dae55d0a96a5
Wong, Paul T.P.
Arslan, Gökmen
Bowers, Victoria L.
Peacock, Edward J.
Kjell, Oscar Nils Erik
Ivtzan, Itai
Lomas, Tim
2021-10-06
The age of COVID-19 calls for a different approach toward global well-being and flourishing through the transcendence suffering as advocated by existential positive psychology. In the present study, we primarily explained what self-transcendence is and why it represents the most promising path for human beings to flourish through the transformation of suffering in a difficult and uncertain world. After reviewing the literature on self-transcendence experiences, we concluded that the model of self-transcendence presented by Frankl is able to integrate both of the characteristics associated with self-transcendence. Afterward, we discussed how the self-transcendence paradigm proposed by Wong, an extension of the model by Frankl, may help awaken our innate capacity for connections with the true self, with others, and with God or something larger than oneself. We presented self-transcendence as a less-traveled but more promising route to achieve personal growth and mental health in troubled times. Finally, we presented the history of the development and psychometrics of the Self-Transcendence Measure-Brief (STM-B) and reported the empirical evidence that self-transcendence served as a buffer against COVID-19 suffering. The presented data in the current study suggested that the best way to overcome pandemic suffering and mental health crises is to cultivate self-transcendence.
https://lup.lub.lu.se/record/a580ec11-187d-4eba-9460-dae55d0a96a5
http://dx.doi.org/10.3389/fpsyg.2021.648549
pmid:34690853
scopus:85114326980
eng
Frontiers in Psychology; 12, no 648549 (2021)
ISSN: 1664-1078
Psychology
COVID-19
existential positive psychology (PP2.0)
existential psychology
mature happiness
meaning
positive psychology
self-transcendence
wellbeing
Self-Transcendence as a Buffer Against COVID-19 Suffering : The Development and Validation of the Self-Transcendence Measure-B
contributiontojournal/article
info:eu-repo/semantics/article
text
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The Paintings Reveal the Story : Case Study of a Well-Known Swedish Artist Suffering from Alzheimer's Disease
https://lup.lub.lu.se/search/publication/807ffd05-ed92-46d4-9a33-1e2f32f51360
Holmbom Larsen, Axel
Londos, Elisabet
2024-02-06
Background: Creativity is a multifaceted, complex, activity, and as such is an overarching function of the brain rather than being confined to a specific structure or region. Alzheimer's disease effects several cognitive domains involved in the creative process of producing art. Objective: We analyze the art of a well-known Swedish visual artist who suffered from Alzheimer's disease to determine if, and in what way, his art and creative process might have been influenced by the disease. Methods: We compared his artistic process and artwork along with information from his spouse, medical r ecords, and cognitive tests as well as reviews of exhibitions written by art critics. Results: We show that not only did the artist continue to produce artwork well into a major decline in cognitive function, according to commonly used tests, but he could continue to do so for even longer with some assistance from his spouse. However, the artwork changed considerably as the disease progressed. We hypothesize that there is a substantial lack of representation of creative ability and function in cognitive tests. Conclusions: Signs of the Alzheimer's disease can be seen in the early artwork if viewed by critics and those with more specialized knowledge into the artist's production. Further analysis of the complex interaction between complex neural activities, such as artistic creativity, and cognitive diseases is warranted and might provide insight in the field of neurological degenerative disease.
https://lup.lub.lu.se/record/807ffd05-ed92-46d4-9a33-1e2f32f51360
http://dx.doi.org/10.3233/ADR-230134
scopus:85184935791
pmid:38405346
eng
Journal of Alzheimer's Disease Reports; 8(1), pp 173-187 (2024)
ISSN: 2542-4823
Art History
Alzheimer's disease
art
cognitive dysfunction
creativity
esthetics
The Paintings Reveal the Story : Case Study of a Well-Known Swedish Artist Suffering from Alzheimer's Disease
contributiontojournal/article
info:eu-repo/semantics/article
text
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Forward dynamics computational modelling of a cyclist fall with the inclusion of protective response using deep learning-based human pose estimation
https://lup.lub.lu.se/search/publication/1ef63f26-92c1-407c-be7c-61c4ab3bef20
Gildea, Kevin
Hall, Daniel
Cherry, Christopher R.
Simms, Ciaran
2024
Single bicycle crashes, i.e., falls and impacts not involving a collision with another road user, are a significantly underestimated road safety problem. The motions and behaviours of falling people, or fall kinematics, are often investigated in the injury biomechanics research field. Understanding the mechanics of a fall can help researchers develop better protective gear and safety measures to reduce the risk of injury. However, little is known about cyclist fall kinematics or dynamics. Therefore, in this study, a video analysis of cyclist falls is performed to investigate common kinematic forms and impact patterns. Furthermore, a pipeline involving deep learning-based human pose estimation and inverse kinematics optimisation is created for extracting human motion from real-world footage of falls to initialise forward dynamics computational human body models. A bracing active response is then optimised for using a genetic algorithm. This is then applied to a case study of a cyclist fall. The kinematic forms characterised in this study can be used to inform initial conditions for computational modelling and injury estimation in cyclist falls. Findings indicate that protective response is an important consideration in fall kinematics and dynamics, and should be included in computational modelling. Furthermore, the novel reconstruction pipeline proposed here can be applied more broadly for traumatic injury biomechanics tasks. The tool developed in this study is available at https://kevgildea.github.io/KinePose/kevgildea.github.io/KinePose/.
https://lup.lub.lu.se/record/1ef63f26-92c1-407c-be7c-61c4ab3bef20
http://dx.doi.org/10.1016/j.jbiomech.2024.111959
scopus:85183450856
pmid:38286096
eng
Journal of Biomechanics; 163, no 111959 (2024)
ISSN: 0021-9290
Vehicle Engineering
Computational modelling
Deep learning
Falls
Human pose estimation
Injury biomechanics
Single bicycle crashes
Video analysis
Forward dynamics computational modelling of a cyclist fall with the inclusion of protective response using deep learning-based human pose estimation
contributiontojournal/article
info:eu-repo/semantics/article
text
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Metabolic profiling of plasma in patients with irritable bowel syndrome after a 4-week starch- and sucrose-reduced diet
https://lup.lub.lu.se/search/publication/b5da0b1d-cf7c-47c6-9603-c7d19c7ac368
Stenlund, Hans
Nilholm, Clara
Chorell, Elin
Roth, Bodil
D’Amato, Mauro
Ohlsson, Bodil
2021-07
A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating metabolite concentrations at the group level, most prominent for reduced starch intake and increased polyunsaturated fat, with small changes in the control group. On an individual level, the correlations were weak. The marked reduction in gastrointestinal symptoms did not correlate with the metabolic changes. SSRD was observed by clear metabolic effects mainly related to linoleic acid metabolism, fatty acid biosynthesis, and beta-oxidation.
https://lup.lub.lu.se/record/b5da0b1d-cf7c-47c6-9603-c7d19c7ac368
http://dx.doi.org/10.3390/metabo11070440
scopus:85109844778
pmid:34357334
eng
Metabolites; 11(7), no 440 (2021)
ISSN: 2218-1989
Gastroenterology and Hepatology
Dietary advice
IBS
Metabolic profiling
Metabolomics
Starch
Sucrose
Metabolic profiling of plasma in patients with irritable bowel syndrome after a 4-week starch- and sucrose-reduced diet
contributiontojournal/article
info:eu-repo/semantics/article
text
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Association between changed self-rated health and the risk of venous thromboembolism in Malmö Preventive Program : a cohort study
https://lup.lub.lu.se/search/publication/6fb0f890-225b-4ead-9205-d256dcc22624
Nymberg, Peter
Milos Nymberg, Veronica
Calling, Susanna
Engström, Gunnar
Svensson, Peter
Elf, Johan
Zöller, Bengt
2024
Poor self-rated health (SRH) is associated with incident arterial cardiovascular disease in both sexes. Studies on the association between SRH and incident venous thromboembolism (VTE) show divergent results in women and no association in men. This study focuses on the association between change in SRH and incident VTE in a cohort of 11,558 men and 6682 women who underwent a baseline examination and assessment of SRH between 1974 and 1992 and a re-examination in 2002–2006. To investigate if changes in SRH over time affect the risk of incident VTE in men and women. During a follow-up time from the re-examination of more than 16 years, there was a lower risk for incident VTE among women if SRH changed from poor at baseline to very good/excellent (HR 0.46, 95% CI 0.28; 0.74) at the re-examination. Stable good SRH (good to very good/excellent at the re-examination, HR 0.60, 95% CI 0.42; 0.89), or change from good SRH at baseline into poor/fair at the re-examination (HR 0.68, 95% CI 0.51; 0.90) were all significantly associated with a reduced risk for VTE. All comparisons were done with the group with stable poor SRH. This pattern was not found among men. Regardless of a decreased or increased SRH during life, having an SRH of very good/excellent at any time point seems to be associated with a decreased risk of VTE among women.
https://lup.lub.lu.se/record/6fb0f890-225b-4ead-9205-d256dcc22624
http://dx.doi.org/10.1007/s11239-023-02933-4
scopus:85182991594
pmid:38265738
eng
Journal of Thrombosis and Thrombolysis; (2024)
ISSN: 0929-5305
Public Health, Global Health, Social Medicine and Epidemiology
Cohort studie
Self-rated health
Venous thromboembolism
Association between changed self-rated health and the risk of venous thromboembolism in Malmö Preventive Program : a cohort study
contributiontojournal/article
info:eu-repo/semantics/article
text
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Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion
https://lup.lub.lu.se/search/publication/84ae6e52-9de9-415a-b6dd-d6298979f377
Verma, Gaurav
Bowen, Alexander
Gheibi, Sevda
Hamilton, Alexander
Muthukumar, Sowndarya
Cataldo, Luis Rodrigo
Asplund, Olof
Esguerra, Jonathan
Karagiannopoulos, Alexandros
Lyons, Claire
Cowan, Elaine
Bellodi, Cristian
Prasad, Rashmi
Fex, Malin
Mulder, Hindrik
2022-02-08
We previously reported that loss of mitochondrial transcription factor B1 (TFB1M) leads to mitochondrial dysfunction and is involved in the pathogenesis of type 2 diabetes (T2D). Whether defects in ribosomal processing impact mitochondrial function and could play a pathogenetic role in β-cells and T2D is not known. To this end, we explored expression and the functional role of dimethyladenosine transferase 1 homolog (DIMT1), a homolog of TFB1M and a ribosomal RNA (rRNA) methyltransferase implicated in the control of rRNA. Expression of DIMT1 was increased in human islets from T2D donors and correlated positively with expression of insulin mRNA, but negatively with insulin secretion. We show that silencing of DIMT1 in insulin-secreting cells impacted mitochondrial function, leading to lower expression of mitochondrial OXPHOS proteins, reduced oxygen consumption rate, dissipated mitochondrial membrane potential, and a slower rate of ATP production. In addition, the rate of protein synthesis was retarded upon DIMT1-deficiency. Consequently, we found that DIMT1 deficiency led to perturbed insulin secretion in rodent cell lines and islets, as well as in a human β-cell line. We observed defects in rRNA processing and reduced interactions between NIN1 (RPN12) binding protein 1 homolog (NOB-1) and Pescadillo ribosomal biogenesis factor 1 (PES-1), critical ribosomal subunit RNA proteins, the dysfunction of which may play a part in disturbing protein synthesis in β-cells. In conclusion, DIMT1 deficiency perturbs protein synthesis, resulting in mitochondrial dysfunction and disrupted insulin secretion, both potential pathogenetic processes in T2D.
https://lup.lub.lu.se/record/84ae6e52-9de9-415a-b6dd-d6298979f377
http://dx.doi.org/10.1016/j.jbc.2022.101692
pmid:35148993
scopus:85126393712
eng
The Journal of biological chemistry; 298(3), no 101692 (2022)
ISSN: 1083-351X
Endocrinology and Diabetes
Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion
contributiontojournal/article
info:eu-repo/semantics/article
text
-
Convalescence plasma treatment of COVID-19 : results from a prematurely terminated randomized controlled open-label study in Southern Sweden
https://lup.lub.lu.se/search/publication/20148598-9f00-4307-b1c6-e7b7a174a3ce
Holm, Karin
Lundgren, Maria N
Kjeldsen-Kragh, Jens
Ljungquist, Oskar
Böttiger, Blenda
Wikén, Christian
Öberg, Jonas
Fernström, Nils
Rosendal, Ebba
Överby, Anna K
Wigren Byström, Julia
Forsell, Mattias
Landin-Olsson, Mona
Rasmussen, Magnus
2021
OBJECTIVE: Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.RESULTS: Hospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6-15) for the convalescent plasma group and 7 days (IQR 5-9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08-2.79). Thus no significant differences were observed between the groups. Trial registration ClinicalTrials NCT04600440, retrospectively registered Oct 23, 2020.
https://lup.lub.lu.se/record/20148598-9f00-4307-b1c6-e7b7a174a3ce
http://dx.doi.org/10.1186/s13104-021-05847-7
pmid:34863304
scopus:85120748357
eng
BMC Research Notes; 14, pp 1-5 (2021)
ISSN: 1756-0500
Infectious Medicine
Anesthesiology and Intensive Care
Convalescence plasma treatment of COVID-19 : results from a prematurely terminated randomized controlled open-label study in Southern Sweden
contributiontojournal/article
info:eu-repo/semantics/article
text
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Impact of Surgery for Primary Hyperparathyroidism
https://lup.lub.lu.se/search/publication/043fabd8-2bb8-4630-9b8a-4b8987d2dbe7
Nilsson, Martin
2024
Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska uppgift är att upprätthålla normala kalciumnivåer i blodet genom att utsöndra PTH. Detta hormon höjer kalciumnivåerna genom att öka konverteringen av D-vitamin till aktiv form, vilket i sin tur höjer upptaget av kalcium från tarmen, minskar utsöndringen av kalcium till urinen och påverkar benomsättningen.Sjukdomen kan orsaka benskörhet och frakturer, njursten och muskelsvaghet, men också kognitiva besvär, nedstämdhet och hjärt-kärlsjukdom. Tidigare upptäcktes sjukdomen oftast i avancerade stadier med uttalade symptom och följdtillstånd. De senaste 50 åren har utveckling gått mot att diagnosen ställs vid avsevärt mildare sjukdom, ofta utan några specifika symptom eller tecken till följdtillstånd.Den enda botande behandlingen är att operera bort den eller de sjuka bisköldkörtlarna. Medicinsk behandling (cinacalcet) kan ges för att lindra symptom vid hög kalciumnivå, men påverkar inte utvecklingen av benskörhet, frakturer, njursten eller hjärt-kärlsjukdom.De flesta undersökningarna av behandlingsresultat vid kirurgi för pHPT är gjorda på patienter med avsevärt mer avancerad sjukdom än vad de flesta patienter har idag. Därför kan vi inte med säkerhet säga att dagens patienter har lika stor nytta av operation. Syftet med denna avhandling är att undersöka hur risken för förtida död, frakturer, benskörhet och hjärt-kärlsjukdom påverkas av operation, samt om vi kan förutsäga vilka patienter som har mest nytta av operation.I den första delstudien undersöktes dödligheten hos patienter som opererats för pHPT jämfört med kontrollpersoner av samma kön, ålder och bostadsort. Patienterna hade inte ökad dödlighet jämfört med kontrollpersonerna, men bland patienterna hade de med högre kalciumnivå i blodet ökad dödlighet. I den andra delstudien undersöktes risken för frakturer före och efter operation för patienter med pHPT, jämfört med kontrollpersoner av samma kön, ålder och bostadsort. Frakturrisken var ökad upp till fyra år före operation, men minskade efter operation till samma nivå som för kontrollpersonerna.I den tredje delstudien undersöktes faktorer för att förutsäga risken för frakturer och sannolikheten för att bentätheten förbättras efter operation för pHPT. Förhöjd mängd kalcium i urin visade sig kunna förutsäga både minskad risk för frakturer efter operation och ökad bentäthet.I den fjärde delstudien undersöktes risken för hjärt-kärlsjukdom före och efter operation för patienter med pHPT, jämfört med kontrollpersoner av samma kön, ålder och bostadsort. Risken för TIA var förhöjd före operation, liksom risken för att utveckla hjärtsvikt eller mitralisstenos, och dessa risker minskade efter operation. Risken att diagnosticeras med pulsåderbråck på aorta var förhöjd hos patienterna, med det påverkades inte av operation. Bland patienterna hade de med högre kalciumnivå i blodet ökad risk för akut hjärtinfarkt, kranskärlssjukdom och hjärtsvikt efter operation.Sammanfattningsvis har nutida patienter med pHPT nytta av kirurgisk behandling i form av minskad risk för frakturer och hjärt-kärlsjukdom. Efter operation är risken för förtida död inte ökad. Bland patienter är risken för hjärt-kärlsjukdom och förtida död störst bland dem med högst kalciumnivå i blodet. Förhöjd mängd kalcium i urinen förutsäger både minskad frakturrisk och förbättrad bentäthet, och ska därför inte förbises vid beslut om kirurgisk behandling.
application/pdf
https://lup.lub.lu.se/record/043fabd8-2bb8-4630-9b8a-4b8987d2dbe7
urn:isbn:978-91-8021-530-5
https://lup.lub.lu.se/search/files/173642649/e-spik_ex_martin.pdf
eng
info:eu-repo/semantics/openAccess
Lund University, Faculty of Medicine Doctoral Dissertation Series; (2024:37) (2024)
ISSN: 1652-8220
Surgery
Endocrinology and Diabetes
primär hyperparatyroidism
paratyroidektomi
mortalitet
frakturer
bone mineral density
hjärt-kärlsjukdom
kalcium
paratyroideahormon
adenom
multiglandulär sjukdom
primary hyperparathyroidism
parathyroidectomy
mortality
fractures
bone mineral density
cardiovascular disease
calcium
parathyroid hormone
adenoma
multiglandular disease
Impact of Surgery for Primary Hyperparathyroidism
thesis/doccomp
info:eu-repo/semantics/doctoralThesis
text
-
Spatially-Coupled Serially Concatenated Codes with Periodic Convolutional Permutors
https://lup.lub.lu.se/search/publication/370a6ce6-3d69-429a-b329-2ef9fb86daa5
Farooq, Muhammad Umar
Amat, Alexandre Graell I
Lentmaier, Michael
2021
Spatially-coupled serially concatenated codes (SC-SCCS) are a class of turbo-like codes constructed by interconnecting a sequence of SCCS using a set of block permutors. At short block lengths, however, the bit-error-rate (BER) performance of SC-SCCS constructed by independent block permutors exhibits a high error floor. In this paper, we propose an alternative method for constructing SC-SCCS to mitigate this problem. Particularly, we use a family of periodically time-varying blockwise convolutional permutors with flexible block length. We derive these convolutional permutors from a block permutor of an optimized spread by applying an unwrapping procedure. We prove that for any chosen block length, the unwrapping procedure preserves the spread of the original block permutor. We further present an efficient implementation method for the blockwise convolutional permutor that derives the permutation indices directly from those of the underlying block permutor. Considering both S-random permutors and quadratic permutation polynomial (QPP) permutors, we perform BER simulations for SC-SCCS with decoding latencies 4096 and 16384. Numerical results show that SC-SCCS based on the proposed convolutional permutors have no visible error floor, which is especially notable at short block lengths.
https://lup.lub.lu.se/record/370a6ce6-3d69-429a-b329-2ef9fb86daa5
http://dx.doi.org/10.1109/ISTC49272.2021.9594196
ISBN: 978-1-6654-0943-8
ISBN: 978-1-6654-0944-5
scopus:85123434429
eng
Telecommunications
Communication Systems
Spatially-Coupled Serially Concatenated Codes with Periodic Convolutional Permutors
contributiontobookanthology/conference
info:eu-repo/semantics/conferencePaper
text
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Osteomodulin Gene Expression Is Associated with Plaque Calcification, Stability, and Fewer Cardiovascular Events in the CPIP Cohort
https://lup.lub.lu.se/search/publication/a913c81d-d1d3-4f65-bd5e-51aef42e0fbc
Gonçalves, Isabel
Oduor, Loureen
Matthes, Frank
Rakem, Narjess
Meryn, Jakob
Skenteris, Nikolaos Taxiarchis
Aspberg, Anders
Orho-Melander, Marju
Nilsson, Jan
Matic, Ljubica
Edsfeldt, Andreas
Sun, Jiangming
Bengtsson, Eva
2022-03-01
Background: Stable atherosclerotic plaques are characterized by thick fibrous caps of smooth muscle cells, collagen, and macrocalcifications. Identifying factors of plaque stability is necessary to design drugs to prevent plaque rupture and symptoms. Osteomodulin, originally identified in bones, is expressed by bone synthesizing osteoblasts and involved in mineralization. In the present study, we analyzed osteomodulin expression in human carotid plaques, its link with plaque phenotype, calcification, and future cardiovascular events. Methods: Osteomodulin gene expression (OMD; n=82) was determined by RNA sequencing and osteomodulin protein levels by immunohistochemistry (n=45) in carotid plaques obtained by endarterectomy from patients with or without cerebrovascular symptoms from the CPIP (Carotid Plaque Imaging Project) cohort, Skåne University Hospital, Sweden. Plaque components were assessed by immunohistochemistry, RNA sequencing, and multiplex analysis. Patients were followed for cardiovascular events or cardiovascular death during a median of 57 or 70 months, respectively, using national registers. Results: OMD levels were increased in plaques from asymptomatic patients compared to symptomatics. High OMD levels were associated with fewer cardiovascular events during follow-up. OMD correlated positively with smooth muscle α-actin (ACTA2; r=0.73, P=10-13) and collagen (COL1A2; r=0.4, P=0.0002), but inversely with CD68 gene expression (r=-0.67, P=10-11), lipids (r=-0.37, P=0.001), intraplaque hemorrhage (r=-0.32, P=0.010), inflammatory cytokine, and matrix metalloproteinase plaque contents. OMD was positively associated with MSX2 (Msh Homeobox 2) (r=0.32, P=0.003), a marker of preosteoblast differentiation, BMP4 (bone morphogenetic protein) (r=0.50, P=0.000002) and BMP6 (r=0.47, P=0.000007), plaque calcification (r=0.35, P=0.016), and was strongly upregulated in osteogenically stimulated smooth muscle cells, which was further increased upon BMP stimulation. Osteomodulin protein was present in calcified regions. Osteomodulin protein levels were associated with plaque calcification (r=0.41, P=0.006) and increased in macrocalcified plaques. Conclusions: These data show that osteomodulin mRNA and protein levels are associated with plaque calcification in human atherosclerosis. Furthermore, osteomodulin mRNA, but not protein levels, is associated with plaque stability.
https://lup.lub.lu.se/record/a913c81d-d1d3-4f65-bd5e-51aef42e0fbc
http://dx.doi.org/10.1161/STROKEAHA.121.037223
scopus:85125554222
pmid:35135320
eng
Stroke; 53(3), pp 79-84 (2022)
ISSN: 0039-2499
Cardiac and Cardiovascular Systems
atherosclerosis
gene expression
immunohistochemistry
osteomodulin
plaques, atherosclerotic
Osteomodulin Gene Expression Is Associated with Plaque Calcification, Stability, and Fewer Cardiovascular Events in the CPIP Cohort
contributiontojournal/article
info:eu-repo/semantics/article
text
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Enhanced Production of Λb0 Baryons in High-Multiplicity pp Collisions at s =13 TeV
https://lup.lub.lu.se/search/publication/4a81f8be-4e52-4703-a7ba-2f003d05344f
Aaij, R.
Ruiz-Vidal, Joan
Zunica, G.
2024
The production rate of Λb0 baryons relative to B0 mesons in pp collisions at a center-of-mass energy s=13 TeV is measured by the LHCb experiment. The ratio of Λb0 to B0 production cross sections shows a significant dependence on both the transverse momentum and the measured charged-particle multiplicity. At low multiplicity, the ratio measured at LHCb is consistent with the value measured in e+e- collisions, and increases by a factor of ∼2 with increasing multiplicity. At relatively low transverse momentum, the ratio of Λb0 to B0 cross sections is higher than what is measured in e+e- collisions, but converges with the e+e- ratio as the momentum increases. These results imply that the evolution of heavy b quarks into final-state hadrons is influenced by the density of the hadronic environment produced in the collision. Comparisons with several models and implications for the mechanisms enforcing quark confinement are discussed. © 2024 CERN.
https://lup.lub.lu.se/record/4a81f8be-4e52-4703-a7ba-2f003d05344f
http://dx.doi.org/10.1103/PhysRevLett.132.081901
scopus:85185840573
eng
Physical Review Letters; 132(8), no 081901 (2024)
ISSN: 1079-7114
Subatomic Physics
Hadrons
Momentum
Tellurium compounds
A-center
Center-of-mass energies
Centre-of-mass energies
Charged particle multiplicities
Final state
Hadronics
High multiplicity
Production cross section
Production rates
Transverse momenta
article
baryon
Charged particles
Enhanced Production of Λb0 Baryons in High-Multiplicity pp Collisions at s =13 TeV
contributiontojournal/article
info:eu-repo/semantics/article
text
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Helium identification with LHCb
https://lup.lub.lu.se/search/publication/84873b1e-9c4c-4013-b3e3-c26fe5247563
Aaij, R.
Ruiz-Vidal, Joan
Zunica, G.
2024
The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √s = 13 TeV recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of 5.5 fb−1. A total of around 105 helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately 50% with a corresponding background rejection rate of up to O(1012). These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei. © 2024 Institute of Physics. All rights reserved.
https://lup.lub.lu.se/record/84873b1e-9c4c-4013-b3e3-c26fe5247563
http://dx.doi.org/10.1088/1748-0221/19/02/P02010
scopus:85185549843
eng
Journal of Instrumentation; 19(2), no P02010 (2024)
ISSN: 1748-0221
Accelerator Physics and Instrumentation
Subatomic Physics
dE/dx detectors
Ion identification systems
Large detector systems for particle and astroparticle physics
Particle identification methods
Astrophysics
Tellurium compounds
Astroparticle physics
De/dx detector
Detector systems
Helium nuclei
Ion identification system
Ion identifications
Large detector system for particle and astroparticle physic
Large detectors
Measurements of
Particle Identification Method
Helium
Helium identification with LHCb
contributiontojournal/article
info:eu-repo/semantics/article
text
-
Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019
https://lup.lub.lu.se/search/publication/4ab47e93-2e83-418f-b56f-2c55c6ad7573
Albinsson, Bo
Hoffman, Tove
Kolstad, Linda
Bergström, Tomas
Bogdanovic, Gordana
Heydecke, Anna
Hägg, Mirja
Kjerstadius, Torbjörn
Lindroth, Ylva
Petersson, Annika
Stenberg, Marie
Vene, Sirkka
Ellström, Patrik
Rönnberg, Bengt
Lundkvist, Åke
2024-01
Background: In Sweden, information on seroprevalence of tick-borne encephalitis virus (TBEV) in the population, including vaccination coverage and infection, is scattered. This is largely due to the absence of a national tick-borne encephalitis (TBE) vaccination registry, scarcity of previous serological studies and use of serological methods not distinguishing between antibodies induced by vaccination and infection. Furthermore, the number of notified TBE cases in Sweden has continued to increase in recent years despite increased vaccination. Aim: The aim was to estimate the TBEV seroprevalence in Sweden. Methods: In 2018 and 2019, 2,700 serum samples from blood donors in nine Swedish regions were analysed using a serological method that can distinguish antibodies induced by vaccination from antibodies elicited by infection. The regions were chosen to reflect differences in notified TBE incidence. Results: The overall seroprevalence varied from 9.7% (95% confidence interval (CI): 6.6–13.6%) to 64.0% (95% CI: 58.3–69.4%) between regions. The proportion of vaccinated individuals ranged from 8.7% (95% CI: 5.8–12.6) to 57.0% (95% CI: 51.2–62.6) and of infected from 1.0% (95% CI: 0.2–3.0) to 7.0% (95% CI: 4.5–10.7). Thus, more than 160,000 and 1,600,000 individuals could have been infected by TBEV and vaccinated against TBE, respectively. The mean manifestation index was 3.1%. Conclusion: A difference was observed between low- and high-incidence TBE regions, on the overall TBEV seroprevalence and when separated into vaccinated and infected individuals. The estimated incidence and manifestation index argue that a large proportion of TBEV infections are not diagnosed.
https://lup.lub.lu.se/record/4ab47e93-2e83-418f-b56f-2c55c6ad7573
http://dx.doi.org/10.2807/1560-7917.ES.2024.29.2.2300221
scopus:85182091674
pmid:38214080
eng
Eurosurveillance; 29(2) (2024)
ISSN: 1025-496X
Infectious Medicine
Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019
contributiontojournal/article
info:eu-repo/semantics/article
text
-
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
https://lup.lub.lu.se/search/publication/67291f8f-9975-41f0-8a5f-8478a6798ea1
Garza, Raquel
Atacho, Diahann A M
Adami, Anita
Gerdes, Patricia
Vinod, Meghna
Hsieh, PingHsun
Karlsson, Ofelia
Horvath, Vivien
Johansson, Pia A
Pandiloski, Ninoslav
Matas-Fuentes, Jon
Quaegebeur, Annelies
Kouli, Antonina
Sharma, Yogita
Jönsson, Marie E
Monni, Emanuela
Englund, Elisabet
Eichler, Evan E
Gale Hammell, Molly
Barker, Roger A
Kokaia, Zaal
Douse, Christopher H
Jakobsson, Johan
2023-11-03
The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demonstrate that L1 promoters are dynamically active in the developing and the adult human brain. L1s generate hundreds of developmentally regulated and cell type-specific transcripts, many that are co-opted as chimeric transcripts or regulatory RNAs. One L1-derived long noncoding RNA, LINC01876, is a human-specific transcript expressed exclusively during brain development. CRISPR interference silencing of LINC01876 results in reduced size of cerebral organoids and premature differentiation of neural progenitors, implicating L1s in human-specific developmental processes. In summary, our results demonstrate that L1-derived transcripts provide a previously undescribed layer of primate- and human-specific transcriptome complexity that contributes to the functional diversification of the human brain.
https://lup.lub.lu.se/record/67291f8f-9975-41f0-8a5f-8478a6798ea1
http://dx.doi.org/10.1126/sciadv.adh9543
pmid:37910626
scopus:85175770022
eng
Science Advances; 9(44), no eadh9543 (2023)
ISSN: 2375-2548
Neurosciences
Animals
Humans
Retroelements/genetics
Transcriptome
Long Interspersed Nucleotide Elements/genetics
Neurons
Primates/genetics
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
contributiontojournal/article
info:eu-repo/semantics/article
text
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Situational vs vasovagal syncope : one but different?
https://lup.lub.lu.se/search/publication/38b5c362-816c-4c4e-afde-acc96e289552
Johansson, Madeleine
Fedorowski, Artur
2024
https://lup.lub.lu.se/record/38b5c362-816c-4c4e-afde-acc96e289552
http://dx.doi.org/10.1136/heartjnl-2023-323180
pmid:37591689
scopus:85168965153
eng
Heart; 110(1), pp 3-4 (2024)
ISSN: 1355-6037
Cardiac and Cardiovascular Systems
Syncope
Situational vs vasovagal syncope : one but different?
contributiontojournal/comment
info:eu-repo/semantics/other
text
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Momentum scale calibration of the LHCb spectrometer
https://lup.lub.lu.se/search/publication/81f434b5-4bf3-43a7-8bd2-64138194de8c
Aaij, R.
Ruiz-Vidal, Joan
Zunica, G.
2024
For accurate determination of particle masses accurate knowledge of the momentum scale of the detectors is crucial. The procedure used to calibrate the momentum scale of the LHCb spectrometer is described and illustrated using the performance obtained with an integrated luminosity of 1.6 fb−1 collected during 2016 in pp running. The procedure uses large samples of J/ → +− and B+ → J/K+ decays and leads to a relative accuracy of 3 × 10−4 on the momentum scale. © 2024 Institute of Physics. All rights reserved.
https://lup.lub.lu.se/record/81f434b5-4bf3-43a7-8bd2-64138194de8c
http://dx.doi.org/10.1088/1748-0221/19/02/P02008
scopus:85185551130
eng
Journal of Instrumentation; 19(2), no P02008 (2024)
ISSN: 1748-0221
Subatomic Physics
Analysis
Particle tracking detectors
statistical methods
Spectrometers
Analyse
Integrated luminosity
Particle mass
Particle tracking
Particle tracking detector
Performance
Relative accuracy
Scale calibration
Tracking detectors
Momentum
Momentum scale calibration of the LHCb spectrometer
contributiontojournal/article
info:eu-repo/semantics/article
text
-
Constraining the reflective properties of WASP-178 b using CHEOPS photometry
https://lup.lub.lu.se/search/publication/ddffaeec-a309-48be-bc03-27e44e47bf3a
Pagano, I.
Davies, M.B.
Walton, N.A.
2024
Context. Multiwavelength photometry of the secondary eclipses of extrasolar planets is able to disentangle the reflected and thermally emitted light radiated from the planetary dayside. Based on this, we can measure the planetary geometric albedo Ag, which is an indicator of the presence of clouds in the atmosphere, and the recirculation efficiency ϵ, which quantifies the energy transport within the atmosphere. Aims. We measure Ag and ϵ for the planet WASP-178 b, a highly irradiated giant planet with an estimated equilibrium temperature of 2450 K. Methods. We analyzed archival spectra and the light curves collected by CHEOPS and TESS to characterize the host WASP-178, refine the ephemeris of the system, and measure the eclipse depth in the passbands of the two telescopes. Results. We measured a marginally significant eclipse depth of 70 ± 40 ppm in the TESS passband, and a statistically significant depth of 70 ± 20 ppm in the CHEOPS passband. Conclusions. Combining the eclipse-depth measurement in the CHEOPS (λeff = 6300 Å) and TESS (λeff = 8000 Å) passbands, we constrained the dayside brightness temperature of WASP-178 b in the 2250-2800 K interval. The geometric albedo 0.1< Ag0.7 makes WASP-178 b an interesting laboratory for testing the current heat-recirculation models. © The Authors 2024.
https://lup.lub.lu.se/record/ddffaeec-a309-48be-bc03-27e44e47bf3a
http://dx.doi.org/10.1051/0004-6361/202346705
scopus:85185216038
eng
Astronomy and Astrophysics; 682, no A102 (2024)
ISSN: 0004-6361
Astronomy, Astrophysics and Cosmology
planets and satellites: atmospheres
planets and satellites: detection
planets and satellites: gaseous planets
planets and satellites: individual: wasp-178 b
techniques: photometric
Exoplanets
Satellites
Solar radiation
Geometric albedos
Pass bands
Planet and satellite: gaseous planet
Planet and satellite: individual: wasp-178 b
Planets and satellites
Planets and satellites: atmospheres
Planets and satellites: detections
Planets and satellites: individual
Recirculations
Techniques: photometric
Photometry
Constraining the reflective properties of WASP-178 b using CHEOPS photometry
contributiontojournal/article
info:eu-repo/semantics/article
text
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CHEOPS observations of KELT-20 b/MASCARA-2 b: An aligned orbit and signs of variability from a reflective day side
https://lup.lub.lu.se/search/publication/92d966ba-0ff7-4459-9f5d-f69e7c546961
Singh, V.
Davies, M.B.
Zingales, T.
2024
Context. Occultations are windows of opportunity to indirectly peek into the dayside atmosphere of exoplanets. High-precision transit events provide information on the spin-orbit alignment of exoplanets around fast-rotating hosts. Aims. We aim to precisely measure the planetary radius and geometric albedo of the ultra-hot Jupiter (UHJ) KELT-20 b along with the spin-orbit alignment of the system. Methods. We obtained optical high-precision transits and occultations of KELT-20 b using CHEOPS observations in conjunction with simultaneous TESS observations. We interpreted the occultation measurements together with archival infrared observations to measure the planetary geometric albedo and dayside temperatures. We further used the host star's gravity-darkened nature to measure the system's obliquity. Results. We present a time-averaged precise occultation depth of 82 ± 6 ppm measured with seven CHEOPS visits and 131-7+8 from the analysis of all available TESS photometry. Using these measurements, we precisely constrain the geometric albedo of KELT-20 b to 0.26 ± 0.04 and the brightness temperature of the dayside hemisphere to 2566-80+77 K. Assuming Lambertian scattering law, we constrain the Bond albedo to 0.36-0.05+0.04 along with a minimal heat transfer to the night side (Ïμ = 0.14-0.10+0.13). Furthermore, using five transit observations we provide stricter constraints of 3 9 ± 1 1 deg on the sky-projected obliquity of the system. Conclusions. The aligned orbit of KELT-20 b is in contrast to previous CHEOPS studies that have found strongly inclined orbits for planets orbiting other A-type stars. The comparably high planetary geometric albedo of KELT-20 b corroborates a known trend of strongly irradiated planets being more reflective. Finally, we tentatively detect signs of temporal variability in the occultation depths, which might indicate variable cloud cover advecting onto the planetary day side. © The Author(s) 2024.
https://lup.lub.lu.se/record/92d966ba-0ff7-4459-9f5d-f69e7c546961
http://dx.doi.org/10.1051/0004-6361/202347533
scopus:85186624090
eng
Astronomy and Astrophysics; 683, no A1 (2024)
ISSN: 0004-6361
Astronomy, Astrophysics and Cosmology
Planets and satellites: atmospheres
Planets and satellites: gaseous planets
Planets and satellites: individual: KELT-20 b
Planets and satellites: individual: MASCARA-2 b
Techniques: photometric
Exoplanets
Geometry
Heat transfer
Photometry
Satellites
Solar radiation
Stars
Exo-planets
Geometric albedos
Planet and satellite: gaseous planet
Planet and satellite: individual: KELT-20 b
Planet and satellite: individual: MASCARA-2 b
Planets and satellites
Planets and satellites: individual
Orbits
CHEOPS observations of KELT-20 b/MASCARA-2 b: An aligned orbit and signs of variability from a reflective day side
contributiontojournal/article
info:eu-repo/semantics/article
text
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
https://lup.lub.lu.se/search/publication/161979b2-f6d8-4bfd-8810-34380c865810
De Marchi, Tommaso
Lai, Chun-Fui
Simmons, Georgia M
Goldsbrough, Isabella
Harrod, Alison
Lam, Thai
Buluwela, Lakjaya
Kjellström, Sven
Brueffer, Christian
Saal, Lao H
Malmström, Johan
Ali, Simak
Niméus, Emma
2024-03-22
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cells to proliferate by employing mechanisms within and without direct regulation by the ER. Although subjected to extensive genetic and transcriptomic analyses, understanding of protein alterations remains poorly investigated. Towards this, we employed an integrated mass spectrometry based proteomic approach to profile the protein and phosphoprotein differences in breast cancer cell lines expressing the frequent Y537N and Y537S ER mutations. Global proteome analysis revealed enrichment of mitotic and immune signaling pathways in ER mutant cells, while phosphoprotein analysis evidenced enriched activity of proliferation associated kinases, in particular CDKs and mTOR. Integration of protein expression and phosphorylation data revealed pathway-dependent discrepancies (motility vs proliferation) that were observed at varying degrees across mutant and wt ER cells. Additionally, protein expression and phosphorylation patterns, while under different regulation, still recapitulated the estrogen-independent phenotype of ER mutant cells. Our study is the first proteome-centric characterization of ESR1 mutant models, out of which we confirm estrogen independence of ER mutants and reveal the enrichment of immune signaling pathways at the proteomic level.
https://lup.lub.lu.se/record/161979b2-f6d8-4bfd-8810-34380c865810
http://dx.doi.org/10.1038/s41598-024-56412-8
pmid:38519482
eng
Scientific Reports; 14, pp 1-16 (2024)
ISSN: 2045-2322
Cancer and Oncology
Humans
Female
Cyclin-Dependent Kinases/genetics
Proteome/genetics
Proteomics
Estrogen Receptor alpha/genetics
Breast Neoplasms/pathology
Mutation
Estrogens
Receptors, Estrogen/genetics
Phosphoproteins/genetics
Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling
contributiontojournal/article
info:eu-repo/semantics/article
text
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Exploring the development of heterogeneous contracting capabilities : the role of organizational design
https://lup.lub.lu.se/search/publication/80814086-0b3b-4e18-8f05-efaf276d8a85
Hallberg, Niklas Lars
2024
Previous research on learning to contract and contracting capabilities suggests that firms in interorganizational relationships adopt contractual designs that economize on transaction costs, and over time learn to govern their relationships in a more efficient manner by incrementally aligning contractual terms with transaction attributes based on new experiences made in their relationships. We augment the learning to contract literature by highlighting the role of organizational design as a factor that may impact contractual learning and the development of heterogeneous contracting capabilities. Specifically, we suggest that the level of specialization and structural integration across the firm’s technical, commercial, and legal functions may affect the effectiveness of contractual learning and the type of learning likely to occur. We also outline boundary conditions for our model in terms of potential interactions between the contractual environment, organizational design, and contractual learning.
https://lup.lub.lu.se/record/80814086-0b3b-4e18-8f05-efaf276d8a85
http://dx.doi.org/10.1177/14761270241244998
eng
Strategic Organization; pp 1-43 (2024)
ISSN: 1476-1270
Business Administration
Contracting Capabilities; Learning to Contract; Organizational Design; Organizational Learning; Transaction Cost Economics
Exploring the development of heterogeneous contracting capabilities : the role of organizational design
contributiontojournal/article
info:eu-repo/semantics/article
text
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Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study
https://lup.lub.lu.se/search/publication/54717e80-9e8e-48b2-8ada-8ee5c06833ff
Fountoulakis, K.N.
Kazakova, O.
Smirnova, D.
2024
Background: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical depression or distress during the pandemic, also in these special populations. Methods: Chi-square tests were used for initial screening to select only those variables which would show an initial significance. Risk Ratios (RR) were calculated, and a Multiple Backward Stepwise Linear Regression Analysis (MBSLRA) was followed with those variables given significant results at screening and with the presence of distress or depression or the lack of both of them. Results: The most important risk factors for depression were female (RR = 1.59–5.49) and non-binary gender (RR = 1.56–7.41), unemployment (RR = 1.41–6.57), not working during lockdowns (RR = 1.43–5.79), bad general health (RR = 2.74–9.98), chronic somatic disorder (RR = 1.22–5.57), history of mental disorders (depression RR = 2.31–9.47; suicide attempt RR = 2.33–9.75; psychosis RR = 2.14–10.08; Bipolar disorder RR = 2.75–12.86), smoking status (RR = 1.15–5.31) and substance use (RR = 1.77–8.01). The risk factors for distress or depression that survived MBSLRA were younger age, being widowed, living alone, bad general health, being a carer, chronic somatic disorder, not working during lockdowns, being single, self-reported history of depression, bipolar disorder, self-harm, suicide attempts and of other mental disorders, smoking, alcohol, and substance use. Conclusions: Targeted preventive interventions are crucial to safeguard the mental health of vulnerable groups, emphasizing the importance of diverse samples in future research. Limitations: Online data collection may have resulted in the underrepresentation of certain population groups. © 2024
https://lup.lub.lu.se/record/54717e80-9e8e-48b2-8ada-8ee5c06833ff
http://dx.doi.org/10.1016/j.jad.2024.02.050
scopus:85186520393
eng
Journal of Affective Disorders; 352, pp 536-551 (2024)
ISSN: 0165-0327
Public Health, Global Health, Social Medicine and Epidemiology
Psychiatry
COVID-19
Depression
Mental health history
Non-binary gender
Risk factors
Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study
contributiontojournal/article
info:eu-repo/semantics/article
text
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Femtoscopic correlations of identical charged pions and kaons in pp collisions at s =13 TeV with event-shape selection
https://lup.lub.lu.se/search/publication/53357f36-bc89-46e6-b40c-2f701896d950
Acharya, S.
Basu, S.
Christiansen, P.
Hansen, J.
Iversen, K.E.
Matonoha, O.
Nepeivoda, R.
Ohlson, A.
Silvermyr, D.
Staa, J.
Vislavicius, V.
Zurlo, N.
2024
Collective behavior has been observed in high-energy heavy-ion collisions for several decades. Collectivity is driven by the high particle multiplicities that are produced in these collisions. At the CERN Large Hadron Collider (LHC), features of collectivity have also been seen in high-multiplicity proton-proton collisions that can attain particle multiplicities comparable to peripheral Pb-Pb collisions. One of the possible signatures of collective behavior is the decrease of femtoscopic radii extracted from pion and kaon pairs emitted from high-multiplicity collisions with increasing pair transverse momentum. This decrease can be described in terms of an approximate transverse mass scaling. In the present work, femtoscopic analyses are carried out by the ALICE Collaboration on charged pion and kaon pairs produced in pp collisions at s=13TeV from the LHC to study possible collectivity in pp collisions. The event-shape analysis method based on transverse sphericity is used to select for spherical versus jetlike events, and the effects of this selection on the femtoscopic radii for both charged pion and kaon pairs are studied. This is the first time this selection method has been applied to charged kaon pairs. An approximate transverse-mass scaling of the radii is found in all multiplicity ranges studied when the difference in the Lorentz boost for pions and kaons is taken into account. This observation does not support the hypothesis of collective expansion of hot and dense matter that should only occur in high-multiplicity events. A possible alternate explanation of the present results is based on a scenario of common emission conditions for pions and kaons in pp collisions for the multiplicity ranges studied. © 2024 CERN.
https://lup.lub.lu.se/record/53357f36-bc89-46e6-b40c-2f701896d950
http://dx.doi.org/10.1103/PhysRevC.109.024915
scopus:85186217652
eng
Physical Review C; 109(2), no 024915 (2024)
ISSN: 2469-9985
Subatomic Physics
Femtoscopic correlations of identical charged pions and kaons in pp collisions at s =13 TeV with event-shape selection
contributiontojournal/article
info:eu-repo/semantics/article
text
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"Take Up Your Cross" : Public Theology Between Populism and Pluralism in the Post-Migrant Context
https://lup.lub.lu.se/search/publication/5aaf43bf-1637-4d87-b51f-83be36ce6ae9
Schmiedel, Ulrich
2019
As of 1 June 2018, the symbol of the cross has to be shown in all state offices of Bavaria in Germany. In order to chart the churches’ reaction, I return to a conversation that Robert N. Bellah and Martin E. Marty had during the 1960s and the 1970s. Drawing on the core concepts of this conversation, I analyze and assess today’s cross controversy as a case of what I call the ‘populist predicament’. I argue that Marty’s programme of public theology provides a path out of the populist predicament because it combines the celebration and the critique of identity. Ultimately, I advocate for a pluralist position of public theology in the post-migrant context.
https://lup.lub.lu.se/record/5aaf43bf-1637-4d87-b51f-83be36ce6ae9
http://dx.doi.org/10.1163/15697320-12341569
scopus:85069158558
eng
International Journal of Public Theology; 13(2), pp 140-162 (2019)
ISSN: 1872-5171
Religious Studies
"Take Up Your Cross" : Public Theology Between Populism and Pluralism in the Post-Migrant Context
contributiontojournal/article
info:eu-repo/semantics/article
text
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Measurements of inclusive J/ψ production at midrapidity and forward rapidity in Pb–Pb collisions at sNN = 5.02 TeV
https://lup.lub.lu.se/search/publication/819bd7db-ac65-4b24-86db-7c33f51b8a9f
Acharya, S.
Basu, S.
Christiansen, P.
Hansen, J.
Iversen, K.E.
Matonoha, O.
Nassirpour, A.F.
Ohlson, A.
Silvermyr, D.
Staa, J.
Vislavicius, V.
Zurlo, N.
2024
https://lup.lub.lu.se/record/819bd7db-ac65-4b24-86db-7c33f51b8a9f
http://dx.doi.org/10.1016/j.physletb.2024.138451
scopus:85185297531
eng
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics; 849, no 138451 (2024)
ISSN: 0370-2693
Subatomic Physics
Measurements of inclusive J/ψ production at midrapidity and forward rapidity in Pb–Pb collisions at sNN = 5.02 TeV
contributiontojournal/article
info:eu-repo/semantics/article
text
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Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden : a study protocol for a national prospective cohort study
https://lup.lub.lu.se/search/publication/c815fed8-fcfb-491c-bede-7734f5929686
Rasmussen, Mette
Larsson, Matz
Gilljam, Hans
Adami, Johanna
Wärjerstam, Sanne
Post, Ann
Björk-Eriksson, Thomas
Helgason, Asgeir R
Tønnesen, Hanne
2022-01-25
INTRODUCTION: Tobacco is still one of the single most important risk factors among the lifestyle habits that cause morbidity and mortality in humans. Furthermore, tobacco has a heavy social gradient, as the consequences are even worse among disadvantaged and vulnerable groups. To reduce tobacco-related inequity in health, those most in need should be offered the most effective tobacco cessation intervention. The aim of this study is to facilitate and improve the evaluation of already implemented national tobacco cessation efforts, focusing on 10 disadvantaged and vulnerable groups of tobacco users.METHODS AND ANALYSIS: This is a prospective cohort study. Data will be collected by established tobacco cessation counsellors in Sweden. The study includes adult tobacco or e-cigarette users, including disadvantaged and vulnerable patients, receiving in-person interventions for tobacco or e-cigarette cessation (smoking, snus and/or e-cigarettes). Patient inclusion was initiated in April 2020. For data analyses patients will be sorted into vulnerable groups based on risk factors and compared with tobacco users without the risk factor in question.The primary outcome is continuous successful quitting after 6 months, measured by self-reporting. Secondary outcomes include abstinence at the end of the treatment programme, which could be from minutes over days to weeks, 14-day point prevalence after 6 months, and patient satisfaction with the intervention. Effectiveness of successful quitting will be examined by comparing vulnerable with non-vulnerable patients using a mixed-effect logistic regression model adjusting for potential prognostic factors and known confounders.ETHICS AND DISSEMINATION: The project will follow the guidelines from the Swedish Data Protection Authority and have been approved by the Swedish Ethical Review Authority before patient inclusion (Dnr: 2019-02221). Only patients providing written informed consent will be included. Both positive and negative results will be published in scientific peer-reviewed journals and presented at national and international conferences. Information will be provided through media available to the public, politicians, healthcare providers and planners as these are all important stakeholders.TRIAL REGISTRATION NUMBER: NCT04819152.
https://lup.lub.lu.se/record/c815fed8-fcfb-491c-bede-7734f5929686
http://dx.doi.org/10.1136/bmjopen-2021-053090
pmid:35078840
scopus:85123816550
eng
BMJ Open; 12(1), pp 1-7 (2022)
ISSN: 2044-6055
Public Health, Global Health, Social Medicine and Epidemiology
Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden : a study protocol for a national prospective cohort study
contributiontojournal/article
info:eu-repo/semantics/article
text
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Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up
https://lup.lub.lu.se/search/publication/f0b8bc2e-d0e7-492b-a194-0e8257656a26
Fawad, Ayesha
Bergmann, Andreas
Schulte, Janin
Butt, Zahra A
Nilsson, Peter M
Bennet, Louise
Orho-Melander, Marju
Melander, Olle
2022-02-17
CONTEXT: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown.OBJECTIVE: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort.METHODS: In the population-based middle-aged cohort (n = 4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT was assessed and total as well as cause-specific mortality was studied. Main cause of death was based on the International Classification of Diseases.RESULTS: During a mean follow-up of 20 ± 3 years, 950 men and 956 women died. There was significantly increased mortality risk in individuals belonging to the highest quartile (Q) of Pro-NT (Q4, Pro-NT ≥ 149 pmol/L) compared with Qs 1 to 3 (Pro-NT < 149 pmol/L), hazard ratio (HR), 95% CI of 1.29 (1.17-1.42; P < .001). Data were adjusted for sex and age. No significant interaction was observed between Pro-NT and sex on mortality risk. Individuals within Q4 vs Qs 1 to 3 had an HR of 1.41 (95% CI, 1.18-1.68; P < .001) for death due to cardiovascular disease (n = 595/4632); 2.53 (95% CI, 1.37-4.67; P = .003), due to digestive tract disease (n = 42/4632), 1.62 (95% CI, 1.04-2.52; P = .032) due to mental and behavioral disease (n = 90/4632); and 1.91 (95% CI, 1.15-3.19; P = .013) due to unspecific causes (n = 64/4632). There was no significant relationship between Pro-NT and deaths due to cancer, infections, neurological, or other causes. Adjustment for cardiovascular risk factors only marginally changed these results.CONCLUSION: The relationship between Pro-NT and total mortality risk was mainly driven by cardiovascular mortality, but high Pro-NT also predicts death from digestive, mental, and behavioral disease and deaths attributed to unspecific causes.
https://lup.lub.lu.se/record/f0b8bc2e-d0e7-492b-a194-0e8257656a26
http://dx.doi.org/10.1210/clinem/dgab755
pmid:34665860
scopus:85124850874
eng
The Journal of clinical endocrinology and metabolism; 107(3), pp 1204-1211 (2022)
ISSN: 1945-7197
Cardiac and Cardiovascular Systems
Aged
Aged, 80 and over
Cause of Death
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neurotensin/blood
Prospective Studies
Protein Precursors/blood
Risk Assessment/methods
Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up
contributiontojournal/article
info:eu-repo/semantics/article
text
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The Politics of Europeanism : "God" in Ernst Troeltsch's War and Post-War Writings
https://lup.lub.lu.se/search/publication/b20e6341-27fa-4a3b-bc70-98032e82b5ff
Schmiedel, Ulrich
2016
For theologians such as Karl Barth the support for Germany’s militaristic ambitions and actions voiced in the manifesto "An die Kulturwelt", published in 1914, was a consequence of the historicization of theology. Ernst Troeltsch (1865-1923), whose interdisciplinary thinking revolved around the significance of history for theology, was labeled the theologian of historicism. Although he had not signed the manifesto, it continues to throw a smokescreen over Troeltsch’s theology. Examining a selection of both his war writings and his post-war writings, I argue that Troeltsch conceptualized a political theology which led him to turn from a clash of cultures to a conversation of cultures. Troeltsch’s historicization of the concept of God allowed him to resist cultural relativism as well as cultural absolutism. Culminating in the concept of "Europeanism (Europäismus)", Troeltsch’s political theology is instructive for a variety of intra- and inter-cultural conversations in Europe today. But in order to unlock its potential, the smokescreen which the manifesto has thrown over Troeltsch’s theology needs to be lifted.
https://lup.lub.lu.se/record/b20e6341-27fa-4a3b-bc70-98032e82b5ff
http://dx.doi.org/10.1515/znth-2016-0004
eng
Zeitschrift für Neuere Theologiegeschichte / Journal for the History of Modern Theology; 22(2), pp 231-249 (2016)
ISSN: 1612-9776
Religious Studies
The Politics of Europeanism : "God" in Ernst Troeltsch's War and Post-War Writings
contributiontojournal/article
info:eu-repo/semantics/article
text
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Transcendence - Taxis - Trust : Richard Kearney and Jacques Derrida
https://lup.lub.lu.se/search/publication/995dc6e4-f2ad-4bbe-8204-07a9df7e2993
Schmiedel, Ulrich
2017
Whatever else it takes to drive a taxi, it takes trust. Day after day, the driver has to decide whether the other is or is not trustworthy. I take the taxi as a test case to analyze and assess Richard Kearney’s diacritical hermeneutics of the other. I argue that Kearney functionalizes the concept of transcendence in order to connect the transcendence of the finite other to the transcendence of the infinite other. However, in his central critique of the deconstructionists following Jacques Derrida, Kearney counters his connection. While Kearney’s critique of Derrida’s account of absolute alterity is correct and compelling, I argue that Derrida’s critique of a distinction between the trustworthy other and the non-trustworthy other might be more crucial than Kearney contends. Insisting on openness to the other’s otherness, Derrida provokes any hermeneutic of the other to trust in transcendence. The taxi is taken as a test to illustrate the implications which diacritical and deconstructive drivers might have for evaluating the entanglement of ethics and eschatology—inside and outside the taxi.
https://lup.lub.lu.se/record/995dc6e4-f2ad-4bbe-8204-07a9df7e2993
http://dx.doi.org/10.3390/rel8030037
scopus:85015436816
eng
Religions; 8(3) (2017)
ISSN: 2077-1444
Religious Studies
Transcendence - Taxis - Trust : Richard Kearney and Jacques Derrida
contributiontojournal/article
info:eu-repo/semantics/article
text
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Coalition - Creation - Church : In Pursuit of a Political Ecclesiology
https://lup.lub.lu.se/search/publication/3519bc1f-e078-4863-ab7e-a1d8b72e5ae8
Schmiedel, Ulrich
2019
Taking the recent UN Report about extreme poverty in the UK as a point of departure, this article analyses and assesses William Cavanaugh’s political ecclesiology. Drawing on the interpretation of Martin Luther’s concept of creation in Scandinavian Creation Theology, I argue that creation destabilises the distinction Cavanaugh draws between what he considers to be church and what he considers not to be church. I account for creation as a web of vulnerability in which all creatures are vulnerable to both creature and creator. In contrast to Cavanaugh’s strong and stable church, I advocate for what I call “coalitional church”: a church that can enter into coalitions with Christians and non-Christians in order to call for conditions under which vulnerable life is liveable. The public and political task of churches is not necessarily to fight the state, but to hold the state accountable to its citizens, whether they are Christian or non-Christian.
https://lup.lub.lu.se/record/3519bc1f-e078-4863-ab7e-a1d8b72e5ae8
http://dx.doi.org/10.1080/0039338X.2019.1667431
scopus:85073932719
eng
Studia Theologica - Nordic Journal of Theology; 73(2), pp 154-178 (2019)
ISSN: 1502-7791
Religious Studies
Coalition - Creation - Church : In Pursuit of a Political Ecclesiology
contributiontojournal/article
info:eu-repo/semantics/article
text
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Elucidating fungal decomposition of organic matter at sub-micrometer spatial scales using optical photothermal infrared (O-PTIR) microspectroscopy
https://lup.lub.lu.se/search/publication/bfa53ffd-c6d9-4efa-a6b6-efdb1df6583f
De Beeck, Michiel Op
Troein, Carl
Peterson, Carsten
Tunlid, Anders
Persson, Per
2024-02
In microbiological studies, a common goal is to link environmental factors to microbial activities. Both environmental factors and microbial activities are typically derived from bulk samples. It is becoming increasingly clear that such bulk environmental parameters poorly represent the microscale environments microorganisms experience. Using infrared (IR) microspectroscopy, the spatial distribution of chemical compound classes can be visualized, making it a useful tool for studying the interactions between microbial cells and their microenvironments. The spatial resolution of conventional IR microspectroscopy has been limited by the diffractionlimit of IR light. The recent development of optical photothermal infrared (O-PTIR) microspectroscopy has pushed the spatial resolution of IR microspectroscopy beyond this diffractionlimit, allowing the distribution of chemical compound classes to be visualized at sub-micrometer spatial scales. To examine the potential and limitations of O-PTIR microspectroscopy to probe the interactions between fungal cells and their immediate environments, we imaged the decomposition of cellulose filmsby cells of the ectomycorrhizal fungus Paxillus involutus and compared O-PTIR results using conventional IR microspectroscopy. Whereas the data collected with conventional IR microspectroscopy indicated that P. involutus has only a very limited ability to decompose cellulose films,O-PTIR data suggested that the ability of P. involutus to decompose cellulose was substantial. Moreover, the O-PTIR method enabled the identificationof a zone located outside the fungal hyphae where the cellulose was decomposed by oxidation. We conclude that O-PTIR can provide valuable new insights into the abilities and mechanisms by which microorganisms interact with their surrounding environments.
https://lup.lub.lu.se/record/bfa53ffd-c6d9-4efa-a6b6-efdb1df6583f
http://dx.doi.org/10.1128/aem.01489-23
scopus:85185705956
pmid:38289133
eng
Applied and Environmental Microbiology; 90(2), no e01489-23. (2024)
ISSN: 0099-2240
Soil Science
cellulose
decomposition
infrared microspectroscopy
microenvironment
microorganism
organic matter
Elucidating fungal decomposition of organic matter at sub-micrometer spatial scales using optical photothermal infrared (O-PTIR) microspectroscopy
contributiontojournal/article
info:eu-repo/semantics/article
text
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Mourning the Un-Mournable? Political Theology Between Refugees and Religion
https://lup.lub.lu.se/search/publication/6e157a89-6461-47a1-96ae-e366efb1a356
Schmiedel, Ulrich
2017
Since the arrival, or the attempted arrival, of millions of refugees in Europe, the performances of the Center for Political Beauty – a Berlin-based collective of artists and activists – have had a huge impact on public and political debates about Germany's migration policies. In this paper, I analyze the performance “The Dead Are Coming” in which the artists buried refugees who drowned in their attempt to enter the European Union. Drawing on Judith Butler's political philosophy of performativity, I assess “The Dead Are Coming” as a “doing” rather than a “describing” of dignity. I argue that the integration of God into the practices of mourning enables both the activists and the audience to resist the differential distribution of dignity in Europe's migration policy. Ultimately, I advocate a re-thinking of political theology in which art learns from theology and theology learns from art in order to promote dignity under de-dignifying conditions.
https://lup.lub.lu.se/record/6e157a89-6461-47a1-96ae-e366efb1a356
http://dx.doi.org/10.1080/1462317X.2017.1291399
scopus:85013633568
eng
Political Theology; 18(7), pp 612-627 (2017)
ISSN: 1462-317X
Religious Studies
Mourning the Un-Mournable? Political Theology Between Refugees and Religion
contributiontojournal/article
info:eu-repo/semantics/article
text
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Search for New Phenomena in Two-Body Invariant Mass Distributions Using Unsupervised Machine Learning for Anomaly Detection at √s = 13 TeV with the ATLAS Detector
https://lup.lub.lu.se/search/publication/f0f650f1-831f-4456-adac-b898d2580c3b
Aad, G.
Åkesson, T.P.A.
Corrigan, E.E.
Doglioni, C.
Geisen, J.
Hansen, E.
Hedberg, V.
Herde, Hannah
Konya, B.
Lytken, E.
Poettgen, R.
Simpson, N.D.
Smirnova, O.
Zwalinski, L.
2024
Searches for new resonances are performed using an unsupervised anomaly-detection technique. Events with at least one electron or muon are selected from 140 fb−1 of pp collisions at √s ¼ 13 TeV recorded by ATLAS at the Large Hadron Collider. The approach involves training an autoencoder on data, and subsequently defining anomalous regions based on the reconstruction loss of the decoder. Studies focus on nine invariant mass spectra that contain pairs of objects consisting of one light jet or b jet and either one lepton (e; μ), photon, or second light jet or b jet in the anomalous regions. No significant deviations from the background hypotheses are observed. Limits on contributions from generic Gaussian signals with various widths of the resonance mass are obtained for nine invariant masses in the anomalous regions. © 2024 CERN, for the ATLAS Collaboration.
https://lup.lub.lu.se/record/f0f650f1-831f-4456-adac-b898d2580c3b
http://dx.doi.org/10.1103/PhysRevLett.132.081801
scopus:85186742137
eng
Physical Review Letters; 132(8), no 081801 (2024)
ISSN: 0031-9007
Subatomic Physics
Anomaly detection
Machine learning
Tellurium compounds
Anomalous regions
ATLAS detectors
Auto encoders
Invariant mass distribution
Large Hadron Collider
Large-hadron colliders
Region-based
Unsupervised anomaly detection
Unsupervised machine learning
Mass spectrometry
Search for New Phenomena in Two-Body Invariant Mass Distributions Using Unsupervised Machine Learning for Anomaly Detection at √s = 13 TeV with the ATLAS Detector
contributiontojournal/article
info:eu-repo/semantics/article
text
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Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018
https://lup.lub.lu.se/search/publication/173dd52b-844c-4e56-b76b-be501e6c5f10
Thorlund, Jonas Bloch
Lundberg, Matilde
Petersen, Jindong Ding
Englund, Martin
Viberg, Bjarke
Waldorff, Frans Boch
Søndergaard, Jens
2023
INTRODUCTION. In the US, opioids are commonly prescribed after arthroscopic knee surgery. We aimed to investigate opioid dispensing in relation to arthroscopic knee surgeries from 2006 to 2018 in Denmark. METHODS. In Danish registries, we identified patients (≥ 15 years old) having arthroscopic knee surgery (anterior cruciate ligament (ACL) reconstruction; meniscal surgery; cartilage resection; synovectomy and diagnostic arthroscopy) between 1 January 2006 and 31 December 2018 and opioid dispensing (oral morphine equivalents (OMEQ)) within seven days after discharge from surgery. RESULTS. Among 218,940 patients, 15,263 (7%) had an opioid dispensed within seven days after being discharged following surgery. The opioid dispensing incidence (per 1,000 persons/year) increased during the study period for all procedures. This trend was more pronounced for ACL reconstruction, which recorded an increase from 86 (95% confidence interval (CI): 75-99) in 2006 to 278 (95% CI: 255-301) in 2018, corresponding to 9% and 28% of ACL patients, respectively. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased (change: 70.0 OMEQ (95% CI: 12.4-127.5)). Tramadol and oxycodone were the most commonly dispensed opioids. CONCLUSION. About 7% of patients had an opioid dispensed within the first seven days after discharge following arthroscopic knee surgery. The incidence of opioids dispensed increased for all investigated procedures from 2006 to 2018. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased.
https://lup.lub.lu.se/record/173dd52b-844c-4e56-b76b-be501e6c5f10
scopus:85168719652
pmid:37622647
eng
Danish Medical Journal; 70(9), no A01230032 (2023)
ISSN: 0011-6092
Orthopedics
Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018
contributiontojournal/article
info:eu-repo/semantics/article
text
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The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and App <sup>NL−F/NL−F</sup> mice
https://lup.lub.lu.se/search/publication/ffafa7be-853f-4f7d-a759-1fe72b72aa13
Nuñez-Diaz, Cristina
Andersson, Emelie
Schultz, Nina
Pocevičiūtė, Dovilė
Hansson, Oskar
Nilsson, K. Peter R.
Wennström, Malin
2024-12
Background: Amyloid beta (Aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of Alzheimer’s disease (AD) patients and transgenic AD mice. Previous studies have shown that retinal microglia engulf Aβ, but this property decreases in AD patients. Whether retinal microglia also take up p-tau and if this event is affected in AD is yet not described. In the current study, we use the p-tau-specific thiophene-based ligand bTVBT2 to investigate the relationship between disease progression and p-tau uptake by microglia in the retina of AD patients and App NL−F/NL−F knock-in mice, an AD mouse model known to demonstrate extracellular Aβ plaques and dystrophic neurites in the brain from 6 months of age. Methods: Evaluation of bTVBT2 specificity and its presence within microglia was assessed by immunofluorescent staining of hippocampal sections and flat-mount retina samples from non-demented controls, AD patients, 3-, 9-, and 12-month-old App NL−F/NL−F knock-in mice and 12- and 18-month-old wild type (WT) mice. We used ImageJ to analyze the amount of bTVBT2 inside Iba1-positive microglia. Co-localization between the ligand and p-tau variant Ser396/Ser404 (PHF-1), Aβ, phosphorylated TAR DNA binding protein 43 (pTDP-43), and islet amyloid polypeptide (IAPP) in the brain and retina was analyzed using confocal imaging. Results: Confocal imaging analysis showed that bTVBT2 binds to PHF-1- and AT8-positive aggregates inside retinal microglia, and not to Aβ, pTDP-43, or IAPP. The density of bTVBT2-positive microglia was higher in cases with a high Aβ load compared to those with a low Aβ load. This density correlated with the neurofibrillary tangle load in the brain, but not with retinal levels of high molecular weight (aggregated) Aβ40 or Aβ42. Analysis of App NL−F/NL−F knock-in mouse retina further showed that 50% of microglia in 3-month-old App NL−F/NL−F knock-in mice contained bTVBT2. The percentage significantly increased in 9- and 12-month-old mice. Conclusion: Our study suggests that the microglial capability to uptake p-tau in the retina persists and intensifies with AD progression. These results also highlight bTVBT2 as a ligand of interest in future monitoring of retinal AD pathology.
https://lup.lub.lu.se/record/ffafa7be-853f-4f7d-a759-1fe72b72aa13
http://dx.doi.org/10.1186/s13195-023-01375-7
scopus:85181464643
pmid:38167557
eng
Alzheimer's Research and Therapy; 16(1), no 4 (2024)
ISSN: 1758-9193
Neurosciences
Alzheimer’s disease
Retina
Tauopathy
Thiophene-based ligands
The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and App NL−F/NL−F mice
contributiontojournal/article
info:eu-repo/semantics/article
text
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Probing the CP nature of the top–Higgs Yukawa coupling in tt¯H and tH events with H→bb¯ decays using the ATLAS detector at the LHC
https://lup.lub.lu.se/search/publication/1eb12e70-d39e-40ce-bd85-55db21558153
Aad, G.
Åkesson, T.P.A.
Corrigan, E.E.
Doglioni, C.
Ekman, P.A.
Geisen, J.
Hedberg, V.
Jarlskog, G.
Konya, B.
Lytken, E.
Mankinen, K.H.
Marcon, C.
Mjörnmark, J.U.
Mullier, G.A.
Poettgen, R.
Simpson, N.D.
Skorda, E.
Smirnova, O.
Zwalinski, L.
2024
The CP properties of the coupling between the Higgs boson and the top quark are investigated using 139 fb−1 of proton–proton collision data recorded by the ATLAS experiment at the LHC at a centre-of-mass energy of s=13 TeV. The CP structure of the top quark–Higgs boson Yukawa coupling is probed in events with a Higgs boson decaying into a pair of b-quarks and produced in association with either a pair of top quarks, tt¯H, or a single top quark, tH. Events containing one or two electrons or muons are used for the measurement. Multivariate techniques are used to select regions enriched in tt¯H and tH events, where dedicated CP-sensitive observables are exploited. In an extension of the Standard Model (SM) with a CP-odd admixture in the top–Higgs Yukawa coupling, the mixing angle between CP-even and CP-odd couplings is measured to be α=11−73∘+52, compatible with the SM prediction corresponding to α=0. © 2024 The Author(s)
https://lup.lub.lu.se/record/1eb12e70-d39e-40ce-bd85-55db21558153
http://dx.doi.org/10.1016/j.physletb.2024.138469
scopus:85185283920
eng
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics; 849, no 138469 (2024)
ISSN: 0370-2693
Subatomic Physics
Probing the CP nature of the top–Higgs Yukawa coupling in tt¯H and tH events with H→bb¯ decays using the ATLAS detector at the LHC
contributiontojournal/article
info:eu-repo/semantics/article
text
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Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke
https://lup.lub.lu.se/search/publication/2c61601f-746e-42df-b1fa-4592165bf049
Aldridge, Chad M.
Braun, Robynne
Lohse, Keith
de Havenon, Adam
Cole, John W.
Cramer, Steven C.
Lindgren, Arne G.
Keene, Keith L.
Hsu, Fang Chi
Worrall, Bradford B.
2024-02
BACKGROUND AND OBJECTIVES: Stroke genetic research has made substantial progress in the past decade. Its recovery application, however, remains behind, in part due to its reliance on the modified Rankin Scale (mRS) score as a measure of poststroke outcome. The mRS does not map well to biological processes because numerous psychosocial factors drive much of what the mRS captures. Second, the mRS contains multiple disparate biological events into a single measure further limiting its use for biological discovery. This led us to investigate the effect of distinct stroke recovery phenotypes on genetic variation associations with Genome-Wide Association Studies (GWASs) by repurposing the NIH Stroke Scale (NIHSS) and its subscores. METHODS: In the Vitamin Intervention for Stroke Prevention cohort, we estimated changes in cognition, motor, and global impairments over 2 years using specific measures. We included genotyped participants with a total NIHSS score greater than zero at randomization and excluded those with recurrent stroke during the trial. A GWAS linear mixed-effects model predicted score changes, with participant as a random effect, and included initial score, age, sex, treatment group, and the first 5 ancestry principal components. RESULTS: In total, 1,270 participants (64% male) were included with a median NIHSS score of 2 (interquartile range [IQR] 1-3) and median age 68 (IQR 59-75) years. At randomization, 20% had cognitive deficits (NIHSS Cog-4 score >0) and 70% had ≥1 motor deficits (impairment score >1). At 2 years, these percentages improved to 7.2% with cognitive deficits and 30% with motor deficits. GWAS identified novel suggestive gene-impairment associations (p < 5e-6) for cognition (CAMK2D, EVX2, LINC0143, PTPRM, SGMS1, and SMAD2), motor (ACBD6, KDM4B, MARK4, PTPRS, ROBO1, and ROBO2), and global (MSR1 and ROBO2) impairments. DISCUSSION: Defining domain-specific stroke recovery phenotypes and using longitudinal clinical trial designs can help detect novel genes associated with chronic recovery. These data support the use of granular endpoints to identify genetic associations related to stroke recovery.
https://lup.lub.lu.se/record/2c61601f-746e-42df-b1fa-4592165bf049
http://dx.doi.org/10.1212/WNL.0000000000208011
scopus:85181629055
pmid:38181310
eng
Neurology; 102(3), no e208011 (2024)
ISSN: 1526-632X
Neurosciences
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke
contributiontojournal/article
info:eu-repo/semantics/article
text
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Outlining recent updates on influenza therapeutics and vaccines : A comprehensive review
https://lup.lub.lu.se/search/publication/c964f3aa-3e2e-4733-9b13-062e1df35337
Malik, Shiza
Asghar, Muhammad
Waheed, Yasir
2024
Influenza virus has presented a considerable healthcare challenge during the past years, particularly in vulnerable groups with compromised immune systems. Therapeutics and vaccination have always been in research annals since the spread of influenza. Efforts have been going on to develop an antiviral therapeutic approach that could assist in better disease management and reduce the overall disease complexity, resistance development, and fatality rates. On the other hand, vaccination presents a chance for effective, long-term, cost-benefit, and preventive response against the morbidity and mortality associated with the influenza. However, the issues of resistance development, strain mutation, antigenic variability, and inability to cure wide-spectrum and large-scale strains of the virus by available vaccines remain there. The article gathers the updated data for the therapeutics and available influenza vaccines, their mechanism of action, shortcomings, and trials under clinical experimentation. A methodological approach has been adopted to identify the prospective therapeutics and available vaccines approved and within the clinical trials against the influenza virus. Review contains influenza therapeutics, including traditional and novel antiviral drugs and inhibitor therapies against influenza virus as well as research trials based on newer drug combinations and latest technologies such as nanotechnology and organic and plant-based natural products. Most recent development of influenza vaccine has been discussed including some updates on traditional vaccination protocols and discussion on next-generation and upgraded novel technologies. This review will help the readers to understand the righteous approach for dealing with influenza virus infection and for deducing futuristic approaches for novel therapeutic and vaccine trials against Influenza.
https://lup.lub.lu.se/record/c964f3aa-3e2e-4733-9b13-062e1df35337
http://dx.doi.org/10.1016/j.jvacx.2024.100452
scopus:85185511846
pmid:38328274
eng
Vaccine: X; 17, no 100452 (2024)
ISSN: 2590-1362
Infectious Medicine
Antiviral agents
Clinical management
Influenza virus
Influenza virus infection
Novel therapeutic
Therapeutics
Treatment
Vaccines
Outlining recent updates on influenza therapeutics and vaccines : A comprehensive review
contributiontojournal/systematicreview
info:eu-repo/semantics/article
text
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Oxidative stress-related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm : a Swedish population-based retrospective cohort study
https://lup.lub.lu.se/search/publication/0b2a64e5-0935-485c-9fc8-1275b9903e75
Vats, Sakshi
Sundquist, Kristina
Sundquist, Jan
Zhang, Naiqi
Wang, Xiao
Acosta, Stefan
Gottsäter, Anders
Memon, Ashfaque A
2024
AIMS: The aim of this study is to investigate how genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and any potential interactions between these factors affect the incidence of intact abdominal aortic aneurysm (AAA) and its rupture (rAAA), accounting for sex differences where possible.METHODS AND RESULTS: The present retrospective cohort study (n = 25 252) uses baseline single-nucleotide polymorphisms (SNPs) and total antioxidant vitamin intake data from the large population-based, Malmö Diet and Cancer Study. Cumulative incidence of intact AAA was 1.6% and of rAAA 0.3% after a median follow-up of 24.3 years. A variant in NOX3 (rs3749930) was associated with higher rAAA risk in males [adjusted hazard ratio (aHR): 2.49; 95% confidence interval (CI): 1.36-4.35] and the overall population (aHR: 1.88; 95% CI: 1.05-3.37). Higher intakes of antioxidant vitamins, riboflavin, and folate were associated with 20% and 19% reduced intact AAA incidence, respectively. Interestingly, the inverse associations between riboflavin and vitamin D intake with intact AAA incidence were stronger in the individuals carrying the NOX3 variant as compared with the wild-type recessive genotype, i.e. by 60% and 66%, respectively (P for interaction < 0.05). Higher riboflavin intake was associated with a 33% male-specific intact AAA risk reduction, while higher intake of vitamin B12 intake was associated with 55% female-specific intact AAA risk increase; both these associations were significantly modified by sex (P for interaction < 0.05).CONCLUSIONS: Our findings highlight the role of oxidative stress genetic variations and antioxidant vitamin intake in AAA. Although a low AAA/rAAA sample size limited some analyses, especially in females, our findings highlight the need for future randomized controlled trials and mechanistic studies, to explore the potential benefits of antioxidant vitamins while accounting for genetic and sex differences.
https://lup.lub.lu.se/record/0b2a64e5-0935-485c-9fc8-1275b9903e75
http://dx.doi.org/10.1093/eurjpc/zwad271
pmid:37665957
scopus:85181797311
eng
European Journal of Preventive Cardiology; 31(1), pp 61-74 (2024)
ISSN: 2047-4881
Cardiac and Cardiovascular Systems
Abdominal aortic aneurysm
Genetics
Vitamins
Oxidative stress
Sex differences
Oxidative stress-related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm : a Swedish population-based retrospective cohort study
contributiontojournal/article
info:eu-repo/semantics/article
text
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Economic Burden of Parkinson’s Disease : A Multinational, Real-World, Cost-of-Illness Study
https://lup.lub.lu.se/search/publication/74353d89-6c1a-474d-ae5e-41e8efbd4646
Chaudhuri, K. Ray
Azulay, Jean Philippe
Odin, Per
Lindvall, Susanna
Domingos, Josefa
Alobaidi, Ali
Kandukuri, Prasanna L.
Chaudhari, Vivek S.
Parra, Juan Carlos
Yamazaki, Toru
Oddsdottir, Julia
Wright, Jack
Martinez-Martin, Pablo
2024
Background: Parkinson’s disease is now one of the fastest-growing neurodegenerative disorders in the developed world, with an increasing prevalence and associated socioeconomic costs. Progression of the disease leads to a gradual deterioration in patients’ quality of life, despite optimal treatment, and both medical and societal needs increase, often with the assistance of paid and/or unpaid caregivers. Objective: We aimed to quantify the incremental economic burden of Parkinson’s disease by disease severity in a real-world setting across differing geographic regions. Methods: Demographics, clinical characteristics, health status, patient quality of life, caregiver burden, and healthcare resource utilization data were drawn from the Adelphi Parkinson’s Disease Specific Program™, conducted in the USA, five European countries, and Japan. Results: A total of 563 neurologists provided data for 5299 individuals with Parkinson’s disease; 61% were male, with a mean age of 64 years. Approximately 15% of individuals were deemed to have advanced disease, with significantly more comorbidities, and a poorer quality of life, than those with non-advanced disease. Overall, the mean annual healthcare resource utilization increased significantly with advancing disease, and resulted in a three-fold difference in the USA and Europe. The main drivers behind the high economic burden included hospitalizations, prescription medications, and indirect costs. Conclusions: People with Parkinson’s disease, and their caregivers, incur a higher economic burden as their disease progresses. Future interventions that can control symptoms or slow disease progression could reduce the burden on people with Parkinson’s disease and their caregivers, whilst also substantially impacting societal costs.
https://lup.lub.lu.se/record/74353d89-6c1a-474d-ae5e-41e8efbd4646
http://dx.doi.org/10.1007/s40801-023-00410-1
scopus:85181904450
pmid:38193999
eng
Drugs - Real World Outcomes; (2024)
ISSN: 2199-1154
Neurology
Economic Burden of Parkinson’s Disease : A Multinational, Real-World, Cost-of-Illness Study
contributiontojournal/article
info:eu-repo/semantics/article
text
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Polarisation vision in the dark : Green-sensitive photoreceptors in the nocturnal ball-rolling dung beetle Escarabaeus satyrus
https://lup.lub.lu.se/search/publication/4ff51de3-f707-43be-83e1-1f56de4fb21e
Yilmaz, Ayse
Belušič, Gregor
Foster, James J.
Tocco, Claudia
Khaldy, Lana
Dacke, Marie
2024
Many insects utilise the polarisation pattern of the sky to adjust their travelling directions. The extraction of directional information from this sky-wide cue is mediated by specialised photoreceptors located in the dorsal rim area (DRA). While this part of the eye is known to be sensitive to the ultraviolet, blue or green component of skylight, the latter has only been observed in insects active in dim light. To address the functional significance of green polarisation sensitivity, we define the spectral and morphological adaptations of the DRA in a nocturnal ball-rolling dung beetle–the only family of insects demonstrated to orient to the dim polarisation pattern in the night sky. Intracellular recordings revealed polarisation-sensitive green photoreceptors in the DRA of Escarabaeus satyrus. Behavioural experiments verified the navigational relevance of this finding. To quantify the adaptive value of green sensitivity for celestial orientation at night, we also obtained the polarisation properties of the night sky in the natural habitat of the beetle. Calculations of relative photon catch revealed that under a moonlit sky the green-sensitive DRA photoreceptors can be expected to catch an order of magnitude more photons compared with the UV-sensitive photoreceptors in the main retina. The green-sensitive photoreceptors – which also show a range of morphological adaptations for enhanced sensitivity – provide E. satyrus with a highly sensitive system for the extraction of directional information from the night sky.
https://lup.lub.lu.se/record/4ff51de3-f707-43be-83e1-1f56de4fb21e
http://dx.doi.org/10.1242/jeb.246374
scopus:85186264608
pmid:38284763
eng
Journal of Experimental Biology; 227(4), no jeb246374 (2024)
ISSN: 0022-0949
Zoology
Dorsal rim area
Dung beetle
Green-sensitive
Nocturnal
Orientation
Polarised light
Polarisation vision in the dark : Green-sensitive photoreceptors in the nocturnal ball-rolling dung beetle Escarabaeus satyrus
contributiontojournal/article
info:eu-repo/semantics/article
text
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Oral glucocorticoid use in patients with rheumatoid arthritis initiating TNF-inhibitors, tocilizumab or abatacept : Results from the international TOCERRA and PANABA observational collaborative studies
https://lup.lub.lu.se/search/publication/49fd0a3f-d2c4-4465-80bf-91ccf9bb9b7c
Lauper, Kim
Mongin, Denis
Bergstra, Sytske Anne
Choquette, Denis
Codreanu, Catalin
Gottenberg, Jacques Eric
Kubo, Satoshi
Hetland, Merete Lund
Iannone, Florenzo
Kristianslund, Eirik K.
Kvien, Tore K.
Lukina, Galina
Mariette, Xavier
Nordström, Dan C.
Pavelka, Karel
Pombo-Suarez, Manuel
Rotar, Ziga
Santos, Maria J.
Tanaka, Yoshiya
Turesson, Carl
Courvoisier, Delphine S.
Finckh, Axel
Gabay, Cem
2024-03
Objective: To evaluate and compare the use of oral glucocorticoids with three classes of bDMARDs in patients with rheumatoid arthritis (RA). Methods: We included patients from 13 observational registries treated with a TNF-inhibitor, abatacept or tocilizumab and with available information on the use of oral glucocorticoids. The main outcome was oral glucocorticoid withdrawal. A McNemar test was used to analyse the change in the use of glucocorticoids after 1 year. Kaplan-Meier estimates and Cox regressions, adjusted for patient, treatment, and disease characteristics, were used to evaluate glucocorticoid discontinuation in patients with glucocorticoids at baseline. Because of heterogeneity, analyses were done by registers and pooled using random-effects meta-analysis. Results: A total of 12,334 participants treated with TNF-inhibitors, 2100 with tocilizumab and 3229 with abatacept were included. At one-year, oral glucocorticoid use decreased in all treatment groups (odds ratio for stopping vs. starting of 2.19 [95% CI 1.58; 3.04] for TNF-inhibitors, 2.46 [1.39; 4.35] for tocilizumab; 1.73 [1.25; 2.21] for abatacept). Median time to glucocorticoid withdrawal was ≈2 years or more in most countries, with a gradual decrease over time. Compared to TNF-inhibitors, crude hazard ratios of glucocorticoid discontinuation were 0.65[0.48–0.87] for abatacept, and 1.04 [0.76–1.43] for tocilizumab, and adjusted hazard ratios were 1.1 [0.83–1.47] for abatacept, and 1.30 [0.96–1.78] for tocilizumab. Conclusion: After initiation of a bDMARD, glucocorticoid use decreased similarly in all treatment groups. However, glucocorticoid withdrawal was much slower than advocated by current international guidelines. More effort should be devoted to glucocorticoid tapering when low disease activity is achieved.
https://lup.lub.lu.se/record/49fd0a3f-d2c4-4465-80bf-91ccf9bb9b7c
http://dx.doi.org/10.1016/j.jbspin.2023.105671
scopus:85181255234
pmid:38042363
eng
Joint Bone Spine; 91(2), no 105671 (2024)
ISSN: 1297-319X
Rheumatology and Autoimmunity
Biologic
Corticosteroid
Epidemiology
IL-6 inhibitor
Observational
Registry
Oral glucocorticoid use in patients with rheumatoid arthritis initiating TNF-inhibitors, tocilizumab or abatacept : Results from the international TOCERRA and PANABA observational collaborative studies
contributiontojournal/article
info:eu-repo/semantics/article
text
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Rapid diversification of a free-living protist is driven by adaptation to climate and habitat
https://lup.lub.lu.se/search/publication/669e0f64-3c6b-4485-a404-0b79767af2c9
Škaloud, Pavel
Jadrná, Iva
Dvořák, Petr
Škvorová, Zuzana
Pusztai, Martin
Čertnerová, Dora
Bestová, Helena
Rengefors, Karin
2024-01
Microbial eukaryotes (protists) have major functional roles in aquatic ecosystems, including the biogeochemical cycling of elements as well as occupying various roles in the food web. Despite their importance for ecosystem function, the factors that drive diversification in protists are not known. Here, we aimed to identify the factors that drive differentiation and, subsequently, speciation in a free-living protist, Synura petersenii (Chrysophyceae). We sampled five different geographic areas and utilized population genomics and quantitative trait analyses. Habitat and climate were the major drivers of diversification on the local geographical scale, while geography played a role over longer distances. In addition to conductivity and temperature, precipitation was one of the most important environmental drivers of differentiation. Our results imply that flushing episodes (floods) drive microalgal adaptation to different niches, highlighting the potential for rapid diversification in protists.
https://lup.lub.lu.se/record/669e0f64-3c6b-4485-a404-0b79767af2c9
http://dx.doi.org/10.1016/j.cub.2023.11.046
scopus:85181839702
pmid:38103550
eng
Current Biology; 34(1), pp 6-105 (2024)
ISSN: 0960-9822
Ecology
algae
gene flow
population genomics
protist
RAD-seq
species diversification
Rapid diversification of a free-living protist is driven by adaptation to climate and habitat
contributiontojournal/article
info:eu-repo/semantics/article
text
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Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium
https://lup.lub.lu.se/search/publication/607146cb-cd32-40f1-b36b-15e4070ebca9
Valentini, Marco
Sagi, Oliver
Baghumyan, Levon
de Gijsel, Thijs
Jung, Jason
Calcaterra, Stefano
Ballabio, Andrea
Aguilera Servin, Juan
Aggarwal, Kushagra
Janik, Marian
Adletzberger, Thomas
Seoane Souto, Rubén
Leijnse, Martin
Danon, Jeroen
Schrade, Constantin
Bakkers, Erik
Chrastina, Daniel
Isella, Giovanni
Katsaros, Georgios
2024
Superconductor/semiconductor hybrid devices have attracted increasing interest in the past years. Superconducting electronics aims to complement semiconductor technology, while hybrid architectures are at the forefront of new ideas such as topological superconductivity and protected qubits. In this work, we engineer the induced superconductivity in two-dimensional germanium hole gas by varying the distance between the quantum well and the aluminum. We demonstrate a hard superconducting gap and realize an electrically and flux tunable superconducting diode using a superconducting quantum interference device (SQUID). This allows to tune the current phase relation (CPR), to a regime where single Cooper pair tunneling is suppressed, creating a sin(2 φ) CPR. Shapiro experiments complement this interpretation and the microwave drive allows to create a diode with ≈ 100% efficiency. The reported results open up the path towards integration of spin qubit devices, microwave resonators and (protected) superconducting qubits on the same silicon technology compatible platform.
https://lup.lub.lu.se/record/607146cb-cd32-40f1-b36b-15e4070ebca9
http://dx.doi.org/10.1038/s41467-023-44114-0
pmid:38167818
scopus:85181236077
eng
Nature Communications; 15(1), no 169 (2024)
ISSN: 2041-1723
Condensed Matter Physics
Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium
contributiontojournal/article
info:eu-repo/semantics/article
text
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Floral scent divergence across an elevational hybrid zone with varying pollinators
https://lup.lub.lu.se/search/publication/66087865-e51c-48d1-b9b1-ae5d65a0b498
García, Yedra
Ostevik, Kate L.
Anderson, Joseph
Rausher, Mark D.
Parachnowitsch, Amy L.
2023-01
Divergence in floral traits attractive to different pollinators can promote reproductive isolation in related species. When isolation is incomplete, hybridization may occur, which offers the opportunity to explore mechanisms underlying reproductive isolation. Recent work suggests that divergence in floral scent may frequently contribute to reproductive barriers, although such divergence has seldom been examined in species with generalized pollination. Here, we used two closely related Penstemon species, P. newberryi and P. davidsonii, and their natural hybrids from an elevational gradient with pollinator communities that are predicted to vary in their reliance on floral scent (i.e., primarily hummingbirds at low elevation vs. bees at high elevation). The species vary in a suite of floral traits, but scent is uncharacterized. To address whether scent varies along elevation and potentially contributes to reproductive isolation, we genetically characterized individuals collected at field and identified whether they were parental species or hybrids. We then characterized scent amount and composition. Although the parental species had similar total emissions, some scent characteristics (i.e., scent composition, aromatic emission) diverged between them and may contribute to their isolation. However, the species emitted similar compound sets which could explain hybridization in the contact area. Hybrids were similar to the parents for most scent traits, suggesting that their floral scent would not provide a strong barrier to backcrossing. Our study suggests floral scent may be a trait contributing to species boundaries even in plants with generalized pollination, and reinforces the idea that evolutionary pollinator transitions may involve changes in multiple floral traits.
https://lup.lub.lu.se/record/66087865-e51c-48d1-b9b1-ae5d65a0b498
http://dx.doi.org/10.1007/s00442-022-05289-3
pmid:36374316
scopus:85142002330
eng
Oecologia; 201(1), pp 45-57 (2023)
ISSN: 0029-8549
Fragrance
Hybridization
Penstemon
Reproductive isolation
Volatile compounds
Floral scent divergence across an elevational hybrid zone with varying pollinators
contributiontojournal/article
info:eu-repo/semantics/article
text
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Water deficit changes patterns of selection on floral signals and nectar rewards in the common morning glory
https://lup.lub.lu.se/search/publication/2cc6e689-72d0-4efa-b46d-3679f28306bc
García, Yedra
Dow, Benjamin S.
Parachnowitsch, Amy L.
2023-10-01
Understanding whether and how resource limitation alters phenotypic selection on floral traits is key to predict the evolution of plant-pollinator interactions under climate change. Two important resources predicted to decline with our changing climate are pollinators and water in the form of increased droughts. Most work, however, has studied these selective agents separately and in the case of water deficit, studies are rare. Here, we use the common morning glory (Ipomoea purpurea) to investigate the effects of experimental reduction in pollinator access and water availability on floral signals and nectar rewards and their effects on phenotypic selection on these traits. We conducted a manipulative experiment in a common garden, where we grew plants in three treatments: (1) pollinator restriction, (2) water reduction and (3) unmanipulated control. Plants in pollinator restriction and control treatments were well-watered compared to water deficit. We found that in contrast to pollinator restriction, water deficit had strong effects altering floral signals and nectar rewards but also differed in the direction and strength of selection on these traits compared to control plants. Water deficit increased the opportunity for selection, and selection in this treatment favoured lower nectar volumes and larger floral sizes, which might further alter pollinator visitation. In addition, well-watered plants, both in control and pollinator deficit, showed similar patterns of selection to increase nectar volume suggesting non-pollinator-mediated selection on nectar. Our study shows that floral traits may evolve in response to reduction in water access faster than to declines in pollinators and reinforces that abiotic factors can be important agents of selection for floral traits. Although only few experimental selection studies have manipulated access to biotic and abiotic resources, our results suggest that this approach is key for understanding how pollination systems may evolve under climate change.
https://lup.lub.lu.se/record/2cc6e689-72d0-4efa-b46d-3679f28306bc
http://dx.doi.org/10.1093/aobpla/plad061
scopus:85172926644
pmid:37899982
eng
AoB Plants; 15(5), no plad061 (2023)
ISSN: 2041-2851
Ecology
Evolutionary Biology
Drought
Ipomoea purpurea
phenotypic selection
pollen limitation
resource limitation
Water deficit changes patterns of selection on floral signals and nectar rewards in the common morning glory
contributiontojournal/article
info:eu-repo/semantics/article
text
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Symptoms during pregnancy in primiparous women with congenital heart disease
https://lup.lub.lu.se/search/publication/57c01a6d-3d5f-40d4-8667-95308d5ed803
Bay, Annika
Berghammer, Malin
Burström, Åsa
Holstad, Ylva
Christersson, Christina
Dellborg, Mikael
Trzebiatowska-Krzynska, Aleksandra
Sörensson, Peder
Thilén, Ulf
Johansson, Bengt
2024
Background: As more women with congenital heart disease (CHD) are reaching childbearing age, it becomes more common for their symptoms to be evaluated during pregnancy. However, pregnancy-related symptoms are similar to those caused by heart disease. This study investigated the prevalence of factors associated with symptoms during pregnancy in women with CHD. Methods: The national birth register was searched for primiparous women with CHD who were registered in the national quality register for patients with CHD. Results: Symptoms during the third trimester were reported in 104 of 465 evaluated women. The most common symptom was palpitations followed by dyspnea. Factors associated with symptoms were tested in a univariable model; higher NYHA classification (>1) (OR 11.3, 95%CI 5.5–23.2), low physical activity (≤3 h/week) (OR 2.1 95%CI 1.3–3.6) and educational level ≤ 12 years (OR 1.9 95%CI 1.2–3.0) were associated with having symptoms. In multivariable analysis, low physical activity level (OR 2.4 95%CI 1.2–5.0) and higher NYHA class (OR 11.3 95%CI 5.0–25.6) remained associated with symptoms during pregnancy. There were no cases with new onset of impaired systemic ventricular function during pregnancy. Conclusion: Symptoms during pregnancy are common in women with CHD but are often already present before pregnancy. Because ordinary symptoms during pregnancy often overlap with symptoms of heart disease, it is important to know if symptoms were present before pregnancy and if they became worse during pregnancy. These results should be included in pre-pregnancy counselling and considered in the monitoring during pregnancy.
https://lup.lub.lu.se/record/57c01a6d-3d5f-40d4-8667-95308d5ed803
http://dx.doi.org/10.1080/14017431.2024.2302135
scopus:85181968010
pmid:38192047
eng
Scandinavian Cardiovascular Journal; 58(1), no 2302135 (2024)
ISSN: 1401-7431
Cardiac and Cardiovascular Systems
Congenital heart disease
pregnancy
pregnancy symptoms
reproductive health
Symptoms during pregnancy in primiparous women with congenital heart disease
contributiontojournal/article
info:eu-repo/semantics/article
text
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Electron and photon energy calibration with the ATLAS detector using LHC Run 2 data
https://lup.lub.lu.se/search/publication/e006cc7e-6f10-44c9-b531-0608ad773897
Aad, G
Åkesson, Torsten
Doglioni, Caterina
Ekman, Alexander
Hedberg, Vincent
Herde, Hannah
Konya, Balazs
Lytken, Else
Pöttgen, Ruth
Simpson, Nathan Daniel
Smirnova, Oxana
Zwalinski, L.
2024
This paper presents the electron and photon energy calibration obtained with the ATLAS detector using 140 fb−1 of LHC proton-proton collision data recorded at √s = 13 TeV between 2015 and 2018. Methods for the measurement of electron and photon energies are outlined, along with the current knowledge of the passive material in front of the ATLAS electromagnetic calorimeter. The energy calibration steps are discussed in detail, with emphasis on the improvements introduced in this paper. The absolute energy scale is set using a large sample of Z-boson decays into electron-positron pairs, and its residual dependence on the electron energy is used for the first time to further constrain systematic uncertainties. The achieved calibration uncertainties are typically 0.05% for electrons from resonant Z-boson decays, 0.4% at ET ∼ 10 GeV, and 0.3% at ET ∼ 1 TeV; for photons at ET ∼ 60 GeV, they are 0.2% on average. This is more than twice as precise as the previous calibration. The new energy calibration is validated using J/ → ee and radiative Z-boson decays. © 2024 Institute of Physics. All rights reserved.
https://lup.lub.lu.se/record/e006cc7e-6f10-44c9-b531-0608ad773897
http://dx.doi.org/10.1088/1748-0221/19/02/P02009
scopus:85185886671
eng
Journal of Instrumentation; 19(2), no P02009 (2024)
ISSN: 1748-0221
Subatomic Physics
calibration
Calorimeter methods; Pattern recognition
cluster finding
fitting methods; Performance of High Energy Physics Detectors
Bosons
Calorimeters
Electron energy levels
Electrons
Pattern recognition
Photons
Tellurium compounds
Calorimeter method;
Cluster finding
Electrons energy
Energy calibration
Fitting method
Fitting method;
High energy physics detector
Performance
Performance of high energy physic detector
Photon energy
Calibration
Electron and photon energy calibration with the ATLAS detector using LHC Run 2 data
contributiontojournal/article
info:eu-repo/semantics/article
text
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Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS
https://lup.lub.lu.se/search/publication/d2f7088a-d529-4fb3-ad61-ab2401c3c793
Stener-Victorin, Elisabet
Eriksson, Gustaw
Mohan Shrestha, Man
Rodriguez Paris, Valentina
Lu, Haojiang
Banks, Jasmine
Samad, Manisha
Perian, Charlène
Jude, Baptiste
Engman, Viktor
Boi, Roberto
Nilsson, Emma
Ling, Charlotte
Nyström, Jenny
Wernstedt Asterholm, Ingrid
Turner, Nigel
Lanner, Johanna
Benrick, Anna
2024
Background: Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in women with PCOS, but these differences do not necessarily lead to changes in protein levels and biological function. Methods: To advance our understanding of the molecular alterations in PCOS, we performed global proteomic and phosphorylation site analysis using tandem mass spectrometry, and analyzed gene expression and methylation. Adipose tissue and skeletal muscle were collected at baseline from 10 women with and without PCOS, and in women with PCOS after 5 weeks of treatment with electrical stimulation. Results: Perilipin-1, a protein that typically coats the surface of lipid droplets in adipocytes, was increased whereas proteins involved in muscle contraction and type I muscle fiber function were downregulated in PCOS muscle. Proteins in the thick and thin filaments had many altered phosphorylation sites, indicating differences in protein activity and function. A mouse model was used to corroborate that androgen exposure leads to a shift in muscle fiber type in controls but not in skeletal muscle-specific androgen receptor knockout mice. The upregulated proteins in muscle post treatment were enriched in pathways involved in extracellular matrix organization and wound healing, which may reflect a protective adaptation to repeated contractions and tissue damage due to needling. A similar, albeit less pronounced, upregulation in extracellular matrix organization pathways was also seen in adipose tissue. Conclusions: Our results suggest that hyperandrogenic women with PCOS have higher levels of extra-myocellular lipids and fewer oxidative insulin-sensitive type I muscle fibers. These could be key factors leading to insulin resistance in PCOS muscle while electric stimulation-induced tissue remodeling may be protective. Funding: Swedish Research Council (2020-02485, 2022-00550, 2020-01463), Novo Nordisk Foundation (NNF22OC0072904), and IngaBritt and Arne Lundberg Foundation. Clinical trial number NTC01457209.
https://lup.lub.lu.se/record/d2f7088a-d529-4fb3-ad61-ab2401c3c793
http://dx.doi.org/10.7554/eLife.87592
scopus:85181630677
pmid:38180081
eng
eLife; 12 (2024)
ISSN: 2050-084X
Physiology
adipose tissue
genetics
genomics
human
medicine
methylation
mouse
PCOS
proteomics
skeletal muscle
transcriptomics
Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS
contributiontojournal/article
info:eu-repo/semantics/article
text
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Addition of nocturnal pollinators modifies the structure of pollination networks
https://lup.lub.lu.se/search/publication/e97ad3de-2edd-40d8-be59-507c4ddc2709
García, Yedra
Giménez-Benavides, Luis
Iriondo, José M.
Lara-Romero, Carlos
Méndez, Marcos
Morente-López, Javier
Santamaría, Silvia
2024-12
Although the ecological network approach has substantially contributed to the study of plant-pollinator interactions, current understanding of their functional structure is biased towards diurnal pollinators. Nocturnal pollinators have been systematically ignored despite the publication of several studies that have tried to alleviate this diurnal bias. Here, we explored whether adding this neglected group of pollinators had a relevant effect on the overall architecture of three high mountain plant-pollinator networks. Including nocturnal moth pollinators modified network properties by decreasing total connectivity, connectance, nestedness and robustness to plant extinction; and increasing web asymmetry and modularity. Nocturnal moths were not preferentially connected to the most linked plants of the networks, and they were grouped into a specific “night” module in only one of the three networks. Our results indicate that ignoring the nocturnal component of plant-pollinator networks may cause changes in network properties different from those expected from random undersampling of diurnal pollinators. Consequently, the neglect of nocturnal interactions may provide a distorted view of the structure of plant-pollinator networks with relevant implications for conservation assessments.
https://lup.lub.lu.se/record/e97ad3de-2edd-40d8-be59-507c4ddc2709
http://dx.doi.org/10.1038/s41598-023-49944-y
scopus:85182245403
pmid:38216624
eng
Scientific Reports; 14, no 1226 (2024)
ISSN: 2045-2322
Ecology
Addition of nocturnal pollinators modifies the structure of pollination networks
contributiontojournal/article
info:eu-repo/semantics/article
text
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Advances in weather radar monitoring of bird movement
https://lup.lub.lu.se/search/publication/3b4e7f0c-e04a-41fb-8da8-534479a5238c
Bringi, V.N
Mishra, Kumar Vijay
Thurai, Merhala
Nilsson, Cecilia
Dokter, Adriaan
Bauer, Silke
Horton, Kyle G.
Farnsworth, Andrew
2023
https://lup.lub.lu.se/record/3b4e7f0c-e04a-41fb-8da8-534479a5238c
http://dx.doi.org/10.1049/SBRA557H_ch7
ISBN: 9781839536274
ISBN: 9781839536267
eng
Ecology
Advances in weather radar monitoring of bird movement
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text
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Widespread Pesticide Distribution in the European Atmosphere Questions their Degradability in Air
https://lup.lub.lu.se/search/publication/869a8d1e-14c7-44ee-bbb7-dc6030508f9f
Mayer, Ludovic
Degrendele, Céline
Šenk, Petr
Kohoutek, Jiři
Přibylová, Petra
Kukučka, Petr
Melymuk, Lisa
Durand, Amandine
Ravier, Sylvain
Alastuey, Andres
Baker, Alex R.
Baltensperger, Urs
Baumann-Stanzer, Kathrin
Biermann, Tobias
Bohlin-Nizzetto, Pernilla
Ceburnis, Darius
Conil, Sébastien
Couret, Cédric
Degórska, Anna
Diapouli, Evangelia
Eckhardt, Sabine
Eleftheriadis, Konstantinos
Forster, Grant L.
Freier, Korbinian
Gheusi, François
Gini, Maria I.
Hellén, Heidi
Henne, Stephan
Herrmann, Hartmut
Holubová Šmejkalová, Adéla
Hõrrak, Urmas
Hüglin, Christoph
Junninen, Heikki
Kristensson, Adam
Langrene, Laurent
Levula, Janne
Lothon, Marie
Ludewig, Elke
Makkonen, Ulla
Matejovičová, Jana
Mihalopoulos, Nikolaos
Mináriková, Veronika
Moche, Wolfgang
Noe, Steffen M.
Pérez, Noemí
Petäjä, Tuukka
Pont, Véronique
Poulain, Laurent
Quivet, Etienne
Ratz, Gabriela
Lammel, Gerhard
2024-02
Risk assessment of pesticide impacts on remote ecosystems makes use of model-estimated degradation in air. Recent studies suggest these degradation rates to be overestimated, questioning current pesticide regulation. Here, we investigated the concentrations of 76 pesticides in Europe at 29 rural, coastal, mountain, and polar sites during the agricultural application season. Overall, 58 pesticides were observed in the European atmosphere. Low spatial variation of 7 pesticides suggests continental-scale atmospheric dispersal. Based on concentrations in free tropospheric air and at Arctic sites, 22 pesticides were identified to be prone to long-range atmospheric transport, which included 15 substances approved for agricultural use in Europe and 7 banned ones. Comparison between concentrations at remote sites and those found at pesticide source areas suggests long atmospheric lifetimes of atrazine, cyprodinil, spiroxamine, tebuconazole, terbuthylazine, and thiacloprid. In general, our findings suggest that atmospheric transport and persistence of pesticides have been underestimated and that their risk assessment needs to be improved.
https://lup.lub.lu.se/record/869a8d1e-14c7-44ee-bbb7-dc6030508f9f
http://dx.doi.org/10.1021/acs.est.3c08488
scopus:85187303663
pmid:38323876
eng
Environmental Science and Technology; 58(7), pp 3342-3352 (2024)
ISSN: 0013-936X
Meteorology and Atmospheric Sciences
Environmental Sciences
atmosphere
Pesticide Distribution
pesticides
risk assessment
transport
air quality
Widespread Pesticide Distribution in the European Atmosphere Questions their Degradability in Air
contributiontojournal/article
info:eu-repo/semantics/article
text
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Capillary leak syndrome was associated with more severe multisystem inflammatory syndrome in children during the COVID-19 pandemic
https://lup.lub.lu.se/search/publication/ac456ef1-aadc-418e-9c08-f09f13c624cd
Kahn, Robin
Mossberg, Maria
Berthold, Elisabet
Schmidt, Tobias
Najibi, Seyed Morteza
Månsson, Bengt
Król, Petra
2024
Aim: This population-based study investigated the occurrence of capillary leak syndrome (CLS) in children with multisystem inflammatory syndrome in children (MIS-C), associated with COVID-19. We also examined associations between CLS and MIS-C disease severity. Methods: All eligible individuals aged 0–18 years, who were diagnosed with MIS-C in Skåne, southern Sweden, from 1 April 2020 to 31 July 2021, were studied. They were all included in the Pediatric Rheumatology Quality Register and clinical and laboratory data were compared between patients with and without CLS. Results: We included 31 patients (61% male) with MIS-C in the study. The median age at diagnosis was 10.6 years (range 1.99–17.15) and 45% developed CLS. All six patients who required intensive care had CLS. Patients with CLS also had a higher incidence of reduced cardiac function, measured as low ejection fraction. The CLS group exhibited significantly higher C-reactive protein values (p < 0.001) and N-terminal pro-B-type natriuretic peptide levels (p < 0.001), as well as lower platelet counts (p = 0.03), during the first week of treatment. Individuals with CLS also received more intense immunosuppression. Conclusion: CLS was a common complication of MIS-C in our study and these patients had a more severe disease course that required more intensive treatment.
https://lup.lub.lu.se/record/ac456ef1-aadc-418e-9c08-f09f13c624cd
http://dx.doi.org/10.1111/apa.17162
scopus:85186252950
pmid:38372417
eng
Acta Paediatrica, International Journal of Paediatrics; (2024)
ISSN: 0803-5253
Pediatrics
Infectious Medicine
immunosuppression
inflammatory response
intensive care
rheumatology
severe disease
Capillary leak syndrome was associated with more severe multisystem inflammatory syndrome in children during the COVID-19 pandemic
contributiontojournal/article
info:eu-repo/semantics/article
text
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Sex pheromone receptors of the light brown apple moth, <i>Epiphyas postvittana</i>, support a second major pheromone receptor clade within the Lepidoptera
https://lup.lub.lu.se/search/publication/c7e28af5-dd7f-4e84-b447-e3ef56c083ee
Yuvaraj, Jothi Kumar
Jordan, Melissa D
Zhang, Dan-Dan
Andersson, Martin N
Löfstedt, Christer
Newcomb, Richard D
Corcoran, Jacob A
2022-02-01
Sex pheromones facilitate species-specific sex communication within the Lepidoptera. They are detected by specialised pheromone receptors (PRs), most of which to date fall into a single monophyletic receptor lineage (frequently referred to as "the PR clade") within the odorant receptor (OR) family. Here we investigated PRs of the invasive horticultural pest, Epiphyas postvittana, commonly known as the light brown apple moth. Ten candidate PRs were selected, based on their male-biased expression in antennae or their relationship to the PR clade, for functional assessment in both HEK293 cells and Xenopus oocytes. Of these, six ORs responded to compounds that include components of the E. postvittana ('Epos') sex pheromone blend or compounds that antagonise sex pheromone attraction. In phylogenies, four of the characterised receptors (EposOR1, 6, 7 and 45) fall within the PR clade and two other male-biased receptors (EposOR30 and 34) group together well outside the PR clade. This new clade of pheromone receptors includes the receptor for (E)-11-tetradecenyl acetate (EposOR30), which is the main component of the sex pheromone blend for this species. Interestingly, receptors of the two clades do not segregate by preference for compounds associated with behavioural response (agonist or antagonist), isomer type (E or Z) or functional group (alcohol or acetate), with examples of each scattered across both clades. Phylogenetic comparison with PRs from other species supports the existence of a second major clade of lepidopteran ORs including, EposOR30 and 34, that has been co-opted into sex pheromone detection in the Lepidoptera. This second clade of sex pheromone receptors has an origin that likely predates the split between the major lepidopteran families.
https://lup.lub.lu.se/record/c7e28af5-dd7f-4e84-b447-e3ef56c083ee
http://dx.doi.org/10.1016/j.ibmb.2021.103708
pmid:34973420
scopus:85122641353
eng
Insect Biochemistry and Molecular Biology; 141, no 103708 (2022)
ISSN: 1879-0240
Biochemistry and Molecular Biology
Evolutionary Biology
sex pheromone
Lepidoptera
PR clade
HEK293 cells
Xenopus oocytes
LBAM
Sex pheromone receptors of the light brown apple moth, Epiphyas postvittana, support a second major pheromone receptor clade within the Lepidoptera
contributiontojournal/article
info:eu-repo/semantics/article
text
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Assessment of a hand-held CZT-based gamma camera for pre-clinical imaging of <sup>177</sup>Lu
https://lup.lub.lu.se/search/publication/eca06b3f-ee54-4c15-a6be-060b89dd39f5
Roth, Daniel
Ljungberg, Michael
Strand, Sven-Erik
2023-10-17
A small CdZnTe-based hand-held gamma-camera has been acquired, intended to be used for preclinical imaging. The camera produces images of size 4 cm x 4 cm with an image-matrix of 16 x 16 pixels and can be equipped with a low-energy high-sensitivity (LEHS) or a high-resolution (LEHR) parallel-hole collimator. Pre-clinical imaging involves scales smaller than what the camera is typically used for, and dedicated assessment of the camera’s performance in this field is thus warranted and the aim of this work. To this end, a mouse-like phantom is developed with the MOBY computer phantom as a basis and manufactured through 3D-printing. The phantom is printed in PLA, with fillable cavities for the liver and a tumour. Additionally, a motorised platform is built enabling SPECT acquisitions by rotating an object in front of the camera. Software is developed in-house for camera operation, SPECT acquisition, and tomographic reconstruction. The camera’s performance for 177 Lu imaging is assessed through measurements on the imageuniformity, sensitivity, spatial resolution, as well as planar and SPECT acquisitions on the mouse phantom. Energy windows over the 55 keV, 113 keV, and 208 keV photopeaks are investigated. Obtained sensitivities are around 100 cps/MBq for the LEHS collimator and 20 cps/MBq for the LEHR collimator, meaning that quick acquisitions can be made with 177 Lu activity administrations that are typically used pre-clinically. Tomographic reconstructions demonstrates that the camera can be used for SPECT applications. Overall, the camera is found promising for pre-clinical applications, both for planar and SPECT imaging.
https://lup.lub.lu.se/record/eca06b3f-ee54-4c15-a6be-060b89dd39f5
http://dx.doi.org/10.1109/NSSMICRTSD49126.2023.10338278
eng
Radiology, Nuclear Medicine and Medical Imaging
Assessment of a hand-held CZT-based gamma camera for pre-clinical imaging of 177Lu
contributiontoconference/poster
info:eu-repo/semantics/conferencePoster
text
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Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
https://lup.lub.lu.se/search/publication/2582e2fd-3f38-40c6-a782-2dcc7e86b938
Rinaldi, Sabina
Dossus, Laure
Keski-Rahkonen, Pekka
Kiss, Agneta
Navionis, Anne Sophie
Biessy, Carine
Travis, Ruth
Weiderpass, Elisabete
Romieu, Isabelle
Eriksen, Anne Kirstine
Tjonneland, Anne
Kvaskoff, Marina
Canonico, Marianne
Truong, Thérèse
Katzke, Verena
Kaaks, Rudolf
Catalano, Alberto
Panico, Salvatore
Masala, Giovanna
Tumino, Rosario
Lukic, Marko
Olsen, Karina Standahl
Zamora-Ros, Raul
Santiuste, Carmen
Aizpurua Atxega, Amaia
Guevara, Marcela
Rodriguez-Barranco, Miguel
Sandstrom, Maria
Hennings, Joakim
Almquist, Martin
Aglago Kouassivi, Elom
Christakoudi, Sofia
Gunter, Marc
Franceschi, Silvia
2024
Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96–2.92, ptrend =.06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96–3.30, ptrend =.06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28–1.05, ptrend =.07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.
https://lup.lub.lu.se/record/2582e2fd-3f38-40c6-a782-2dcc7e86b938
http://dx.doi.org/10.1002/ijc.34872
scopus:85185665624
pmid:38357914
eng
International Journal of Cancer; (2024)
ISSN: 0020-7136
Cancer and Oncology
differentiated thyroid cancer
prospective study
sex steroids
Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
contributiontojournal/article
info:eu-repo/semantics/article
text
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Wave packet dynamics and control in excited states of molecular nitrogen
https://lup.lub.lu.se/search/publication/3d45f94e-f3f8-4e2a-96b4-3405294d1fbd
Fushitani, Mizuho
Fujise, Hikaru
Hishikawa, Akiyoshi
You, Daehyun
Saito, Shu
Luo, Yu
Ueda, Kiyoshi
Ibrahim, Heide
Légaré, Francois
Pratt, Stephen T
Eng-Johnsson, Per
Mauritsson, Johan
Olofsson, Anna
Peschel, Jasper
Simpson, Emma R
Carpeggiani, Paolo Antonio
Ertel, Dominik
Maroju, Praveen Kumar
Moioli, Matteo
Sansone, Giuseppe
Shah, Ronak
Csizmadia, Tamás
Dumergue, Mathieu
Nandiga Gopalakrishna, Harshitha
Kühn, Sergei
Callegari, Carlo
Danailov, Miltcho
Demidovich, Alexander
Raimondi, Lorenzo
Zangrando, Marco
De Ninno, Giovanni
Di Fraia, Michele
Giannessi, Luca
Plekan, Oksana
Rebernik Ribic, Primoz
Prince, Kevin C
2024-03-14
Wave packet interferometry with vacuum ultraviolet light has been used to probe a complex region of the electronic spectrum of molecular nitrogen, N2. Wave packets of Rydberg and valence states were excited by using double pulses of vacuum ultraviolet (VUV), free-electron-laser (FEL) light. These wave packets were composed of contributions from multiple electronic states with a moderate principal quantum number (n ∼ 4-9) and a range of vibrational and rotational quantum numbers. The phase relationship of the two FEL pulses varied in time, but as demonstrated previously, a shot-by-shot analysis allows the spectra to be sorted according to the phase between the two pulses. The wave packets were probed by angle-resolved photoionization using an infrared pulse with a variable delay after the pair of excitation pulses. The photoelectron branching fractions and angular distributions display oscillations that depend on both the time delays and the relative phases of the VUV pulses. The combination of frequency, time delay, and phase selection provides significant control over the ionization process and ultimately improves the ability to analyze and assign complex molecular spectra.
https://lup.lub.lu.se/record/3d45f94e-f3f8-4e2a-96b4-3405294d1fbd
http://dx.doi.org/10.1063/5.0188182
pmid:38469909
eng
The Journal of chemical physics; 160(10), no 104203 (2024)
ISSN: 0021-9606
Atom and Molecular Physics and Optics
Wave packet dynamics and control in excited states of molecular nitrogen
contributiontojournal/article
info:eu-repo/semantics/article
text
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The genome sequence of the Brown Argus, Aricia agestis (Denis & Schiffermüller, 1775)
https://lup.lub.lu.se/search/publication/196a55ff-5d03-4283-8678-af7c25744cef
Hayward, Alex
Lohse, Konrad
Vila, Roger
Laetsch, Dominik R.
Hedlund, Johanna S.U.
2023
We present genome assemblies from two male Aricia agestis specimens (the Brown Argus; Arthropoda; Insecta; Lepidoptera; Lycaenidae). The genome sequences are 435.3 and 437.4 megabases in span. Each assembly is scaffolded into 23 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genomes were assembled and are 15.47 and 15.45 kilobases in length. Gene annotation of these assemblies on Ensembl identified 12,688 and 12,654 protein coding genes.
https://lup.lub.lu.se/record/196a55ff-5d03-4283-8678-af7c25744cef
http://dx.doi.org/10.12688/wellcomeopenres.19784.1
scopus:85186896009
eng
Wellcome Open Research; 8, no 336 (2023)
ISSN: 2398-502X
Genetics
Aricia agestis
Brown Argus
chromosomal
genome sequence
Lepidoptera
The genome sequence of the Brown Argus, Aricia agestis (Denis & Schiffermüller, 1775)
contributiontojournal/article
info:eu-repo/semantics/article
text
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Decentralized leader-follower control for centroid and formation tracking
https://lup.lub.lu.se/search/publication/f04a29fc-3886-451f-8e59-a533e00c69c8
Sileo, Monica
Karayiannidis, Yiannis
Pierri, Francesco
Caccavale, Fabrizio
2023-10-01
In this paper, a novel decentralized leader-follower control scheme for multi–agent systems is devised, where each agent communicates only with a subset of neighboring mates. The goal is to track assigned trajectories for the centroid and the formation of the system. The desired trajectories are known only by a subset of agents, named leaders: the other agents, the followers, are required to estimate the desired trajectories based on a dynamic consensus scheme. Then, the desired trajectories to be tracked by each agent are computed from the estimated trajectories for the centroid and the formation and a simple local control loop is adopted to track the former. Stability and performance are analyzed and experiments are run on Robotarium platform to show the effectiveness of the approach and the effect of different parameters on the achieved performance.
https://lup.lub.lu.se/record/f04a29fc-3886-451f-8e59-a533e00c69c8
http://dx.doi.org/10.1109/SMC53992.2023.10394056
ISBN: 979-835033702-0
scopus:85187298817
eng
Control Engineering
Decentralized leader-follower control for centroid and formation tracking
contributiontobookanthology/conference
info:eu-repo/semantics/conferencePaper
text
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Seasonal movements of Black Coucals Centropus grillii in Nigeria
https://lup.lub.lu.se/search/publication/6bd05696-c27b-433d-90da-282423a40bba
Iwajomo, Soladoye B.
Bakam, Himma
Manu, Shiiwua A.
Ottosson, Ulf
Thorup, Kasper
2024
The scale of movement associated with the migration of many intra-African bird species is still poorly known even with the increasing availability of tracking devices. In this study, we tracked the movements of Black Coucals Centropus grillii breeding in Nigeria from late July using satellite telemetry. Individuals remained on the breeding site for several months; two individuals transmitted after October and these two moved shorter distances (< 100 km) away from the breeding site in early December. One of these was tracked for a full year, moving to a site 175 km south of the breeding site in early January and returning to the breeding site in late May. The bird migrated faster during the return journey (58 km day−1) as compared to the post-breeding journey (5.9 km day−1). The overall home range (90% kernel density) during breeding was 20.4 ± 3.3 km2 (mean ± s.d.) and the core (50%) 5.0 ± 1.6 km2 with no apparent clear change outside of the breeding season. Vegetation conditions at the distant site were apparently poorer although in an average year the move would have led to improved conditions. Short-distance seasonal migration of Black Coucals might be widespread in drier seasonal habitats.
https://lup.lub.lu.se/record/6bd05696-c27b-433d-90da-282423a40bba
http://dx.doi.org/10.2989/00306525.2023.2297378
scopus:85187192971
eng
Ostrich; (2024)
ISSN: 0030-6525
Ecology
intra-African bird migration
short-distance migration
vegetation greenness
Seasonal movements of Black Coucals Centropus grillii in Nigeria
contributiontojournal/article
info:eu-repo/semantics/article
text
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Physiological responses to pH in the freshwater microalga Limnomonas gaiensis
https://lup.lub.lu.se/search/publication/0333c9c4-bc48-48f4-83f8-25e8937ccbbe
Tesson, Sylvie V.M.
2023-05-25
The ecological niche of the recently described limnic microalga Limnomonas gaiensis (Chlamydomonadales) in Northern Europe remains unknown. To decipher the species tolerance capacity to pH, the effects of hydrogen ions on the physiological response of L. gaiensis were investigated. Results showed that L. gaiensis could tolerate exposure from pH 3 up to pH 11, with an optimal survival at pH 5–8. Its physiological response to pH was strain specific. Globally the southernmost strain was more alkaliphilic, had a slightly rounder shape, a slowest growth rate, and a lowest carrying capacity. Despite strain discrepancies among lakes, Swedish strains exhibited similar growth rates, faster at more acidic conditions. The extreme pH conditions affected its morphological features such as the eye spot and papilla shape, especially at acidic pH, and the cell wall integrity, at more alkaline pH. The wide range tolerance of L. gaiensis to pH would not be a hindrance to its dispersal in Swedish lakes (pH 4–8). Notably, the storage of high-energetic reserves over a wide range of pH conditions, as numerous starch grains and oil droplets, makes L. gaiensis a good candidate for bioethanol/fuel industrial production and a key resource to sustain aquatic food chain and microbial loop.
https://lup.lub.lu.se/record/0333c9c4-bc48-48f4-83f8-25e8937ccbbe
http://dx.doi.org/10.1002/jobm.202300107
pmid:37229780
scopus:85160286661
eng
Journal of Basic Microbiology; 63(8), pp 944-956 (2023)
ISSN: 1521-4028
Physiological responses to pH in the freshwater microalga Limnomonas gaiensis
contributiontojournal/article
info:eu-repo/semantics/article
text
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Aerosolization flux, bio-products, and dispersal capacities in the freshwater microalga Limnomonas gaiensis (Chlorophyceae)
https://lup.lub.lu.se/search/publication/9fb641b3-891e-46f2-9135-6e119a482fa2
Tesson, Sylvie V.M.
Barbato, Marta
Rosati, Bernadette
2023-08-03
Little is known on the spreading capacities of Limnomonas gaiensis across freshwater lakes in Northern Europe. In this study, we show that the species could successfully be aerosolized from water sources by bubble bursting (2-40 particles.cm−3), irrespectively of its density in the water source or of the jet velocity used to simulate wave breaking. The species viability was impacted by both water turbulences and aerosolization. The survival rate of emitted cells was low, strain-specific, and differently impacted by bubble busting processes. The entity “microalga and bionts” could produce ethanol, and actively nucleate ice (principally ≤−18 °C) mediated soluble ice nucleation active proteins, thereby potentially impacting smog and cloud formation. Moreover, smallest strains could better cope with applied stressors. Survival to short-term exposure to temperatures down to −21 °C and freezing events further suggest that L. gaiensis could be air dispersed and contribute to their deposition.
https://lup.lub.lu.se/record/9fb641b3-891e-46f2-9135-6e119a482fa2
http://dx.doi.org/10.1038/s42003-023-05183-5
pmid:37537210
scopus:85166575030
eng
Communications Biology; 6, no 809 (2023)
ISSN: 2399-3642
Aerosolization flux, bio-products, and dispersal capacities in the freshwater microalga Limnomonas gaiensis (Chlorophyceae)
contributiontojournal/article
info:eu-repo/semantics/article
text
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No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner
https://lup.lub.lu.se/search/publication/c3672398-bba7-40c8-bb01-33f73cda86ff
Baubeta, Erik
Laurin Gadsböll, Eva
Will, Leon
Holmquist, Fredrik
Aurumskjöld, Marie‐louise
2024-03-12
PurposeThis study aimed to elucidate whether gadolinium contrast in clinically relevant doses can be used with photon-counting computed tomography (PCCT) as an alternative contrast agent in clinical applications.Material/methodsA CTDI phantom with 3D printed rods filled with different concentrations of gadolinium and iodine contrast was scanned in a PCCT and an energy-integrated computed tomography (EICT). Attenuation values at different monoenergetic steps were extracted for each contrast concentration.ResultsFor PCCT, gadolinium reached an attenuation >100 HU (103 HU) at 40 keV with a concentration 5 mmol/L whereas the same level was reached at 50 keV (118 HU) for 10 mmol/L and 90 keV (114 HU) for 25 mmol/L. For iodine, the same level of attenuation was reached at 100 keV (106 HU) with a concentration 8.75 mg I/mL.For EICT the lowest gadolinium contrast concentration needed to reach >100 HU (108 HU) was 10 mmol/L at 50 keV. For 25 mmol/L 100 HU was reached at 100 keV. For iodine contrast 108 HU was reached at 110 keV for 8.75 mg I/mL.ConclusionNo K-edge potential or difference in attenuation curves between iodine and gadolinium contrast is detected on the first clinical available PCCT. Clinically relevant attenuation levels were barely achieved in this setting with gadolinium concentrations approved for human use. The results of this study suggest that, given current scanning technology, gadolinium is not a clinically useful contrast agent for computed tomography because no K-edge was detected.
https://lup.lub.lu.se/record/c3672398-bba7-40c8-bb01-33f73cda86ff
http://dx.doi.org/10.1002/acm2.14324
pmid:38470449
scopus:85187410880
eng
Journal of Applied Clinical Medical Physics; pp 1-7 (2024)
ISSN: 1526-9914
Radiology, Nuclear Medicine and Medical Imaging
No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner
contributiontojournal/article
info:eu-repo/semantics/article
text
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Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis
https://lup.lub.lu.se/search/publication/9b13b686-1554-4f1e-bbad-18e803ccbcbc
Mastropasqua, Francesca
Oksanen, Marika
Soldini, Cristina
Alatar, Shemim
Arora, Abishek
Ballarino, Roberto
Molinari, Maya
Agostini, Federico
Poulet, Axel
Watts, Michelle
Rabkina, Ielyzaveta
Becker, Martin
Li, Danyang
Anderlid, Britt Marie
Isaksson, Johan
Remnelius, Karl Lundin
Moslem, Mohsen
Jacob, Yannick
Falk, Anna
Crosetto, Nicola
Bienko, Magda
Santini, Emanuela
Borgkvist, Anders
Bölte, Sven
Tammimies, Kristiina
2023-10
Genetic variants affectingHeterogeneousNuclear RibonucleoproteinU (HNRNPU) have been identified in several neurodevelopmental disorders (NDDs). HNRNPU is widely expressed in the human brain and shows the highest postnatal expression in the cerebellum. Recent studies have investigated the role of HNRNPU in cerebral cortical development, but the effects of HNRNPU deficiency on cerebellar development remain unknown. Here, we describe the molecular and cellular outcomes of HNRNPU locus deficiency during in vitro neural differentiation of patient-derived and isogenic neuroepithelial stem cells with a hindbrain profile. We demonstrate that HNRNPU deficiency leads to chromatin remodeling of A/B compartments, and transcriptional rewiring, partly by impacting exon inclusion during mRNA processing. Genomic regions affected by the chromatin restructuring and host genes of exon usage differences show a strong enrichment for genes implicated in epilepsies, intellectual disability, and autism. Lastly, we show that at the cellular level HNRNPU downregulation leads to an increased fraction of neural progenitors in the maturing neuronal population. We conclude that the HNRNPU locus is involved in delayed commitment of neural progenitors to differentiate in cell types with hindbrain profile.
https://lup.lub.lu.se/record/9b13b686-1554-4f1e-bbad-18e803ccbcbc
http://dx.doi.org/10.1242/bio.060113
scopus:85187921546
eng
Biology Open; 12(10), no bio060113 (2023)
ISSN: 2046-6390
Medical Genetics
HiC-sequencing
Hindbrain
HNRNPU
Neurodevelopmental disorders
Neurogenesis
RNA-sequencing
Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis
contributiontojournal/article
info:eu-repo/semantics/article
text
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The pH tolerance range of the airborne species Tetracystis vinatzeri (Chlorophyceae, Chlamydomonadales)
https://lup.lub.lu.se/search/publication/e05d42f2-77b6-422e-9ca7-78cad1f762dd
Tesson, Sylvie V.M.
Sildever, Sirje
2023-10-20
To decipher the dispersal range of the cosmopolitan green microalga Tetracystis vinatzeri, two airborne-collected strains were barcoded using the 18S ribosomal DNA gene (18S) and the mitochondrial cytochrome c oxidase I subunit (COI), and their survival capacities were investigated across a stepwise acidic to alkaline pH gradient. Genetic fingerprinting confirmed the identity of the strains as representing the same biological species. Investigations of the tolerance of T. vinatzeri to pH levels refined the delimitation of its ecological niche. T. vinatzeri showed optimal growth in freshwater habitats at pH 4.3–9.6 and strains could cope with exposure to slightly more acidic (down to 3.8) and alkaline (up to 10.4) conditions. However, organismal survival was drastically affected by exposure to pH < 3 and > 11. Morphological observations showed that T. vinatzeri could better cope with exposure to acidic pH, exhibiting less cell membrane damage. Genetic analysis showed that the two airborne strains shared the same haplotype, suggesting that they either originated from the same air mass or that the haplotype has a widespread distribution. Further phylogeographic and physiological investigations are required to define the spreading dynamic of T. vinatzeri.
https://lup.lub.lu.se/record/e05d42f2-77b6-422e-9ca7-78cad1f762dd
http://dx.doi.org/10.1080/09670262.2023.2260444
scopus:85174388127
eng
European Journal of Phycology; (2023)
ISSN: 1469-4433
The pH tolerance range of the airborne species Tetracystis vinatzeri (Chlorophyceae, Chlamydomonadales)
contributiontojournal/article
info:eu-repo/semantics/article
text
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A late modern state of mind : The cityscape of Istanbul and Orhan Pamuk
https://lup.lub.lu.se/search/publication/4c0078be-8709-4938-8b4f-2fb16273fef1
Akpinar, Ipek
Güngören, Elâ
Mårtelius, Johan
Olsson, Gertrud
Magnusson Staaf, Björn
2021
https://lup.lub.lu.se/record/4c0078be-8709-4938-8b4f-2fb16273fef1
ISBN: 9789188929372
eng
Transactions; 24, pp 141-153 (2021)
ISSN: 1100-0333
Architecture
History
Cultural Studies
heritage and memories
A late modern state of mind : The cityscape of Istanbul and Orhan Pamuk
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text
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Factors contributing to the potential expansion of Limnomonas gaiensis (Chlamydomonadales, Chlorophyta) in freshwater lakes in Northern Europe
https://lup.lub.lu.se/search/publication/e4b5305d-4ac6-4284-8111-f559d245269d
Sildever, Sirje
Stewart, Rebecca I.A.
Tesson, Sylvie V.M.
2023-12-07
Limnomonas gaiensis is a recently described green microalga inhabiting freshwater lakes in northern Europe (England, Sweden). There is little information on the species’ tolerance to environmental factors and its capacity to spread to unconnected lakes. Using a barcoding approach, we investigated the phylogeography of L. gaiensis along a latitudinal gradient spanning 54–60°N. Experimental long-term exposure to a gradient of water temperatures, mimicking natural conditions, was performed to assess its thermal tolerance. Genetic analyses showed that this limnic species is easily identified at the species level. Phylogeographic analyses revealed the existence of two genetically similar haplotypes over the mitochondrial cytochrome C oxidase subunit 1 gene in different countries, suggesting that the range of L. gaiensis has recently expanded from a common source lineage, despite geographic isolation. Heterogeneity in the Helix III of the nuclear Internal Transcribed Spacer 2 region of the English strain suggested past hybridization. Physiological analyses showed that L. gaiensis can survive and reproduce asexually, potentially year-round. Optimal growth was observed at 15°C, with a doubling time of 1.1 days. The species is able to survive short periods of desiccation. The lack of connectivity between the lakes where the species was sampled rules out aquatic dispersal of this species. However, its physiological features make L. gaiensis a good candidate for propagule dispersal by either wind or human/animal-mediated transportation. Our study calls for further investigation into limnic systems, using rapid barcoding, with concurrent atmospheric and physiological analyses to establish its distribution over wider geographic scales and to understand how L. gaiensis disperses.
https://lup.lub.lu.se/record/e4b5305d-4ac6-4284-8111-f559d245269d
http://dx.doi.org/10.1080/09670262.2023.2274080
scopus:85179992485
eng
European Journal of Phycology; (2023)
ISSN: 1469-4433
Factors contributing to the potential expansion of Limnomonas gaiensis (Chlamydomonadales, Chlorophyta) in freshwater lakes in Northern Europe
contributiontojournal/article
info:eu-repo/semantics/article
text
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Resisting Democratisation : Arguments Against Female Enfranchisement Among Members of the Swedish Parliament 1866–1918
https://lup.lub.lu.se/search/publication/94267565-a919-4faf-a892-6f0bc90fdc25
Erikson, Josefina
Freidenvall, Lenita
Brunnström, Pål
Olofsson, Magnus
2024-02-29
In this contribution, we analyse the parliamentary minutes debating the issue of women’s voting rights in Sweden from the start of the two-chamber parliament in 1866 until 1918, when women were finally granted voting rights on the same terms as men. We find that most arguments belonged to one of two broad categories: those that were against women’s suffrage as a matter of principle, and those that could accept women’s right to vote but not at the present time. The arguments of principle were without exception used by conservatives, and while some liberals did occasionally use postponement arguments, this was also the realm of conservative argumentation. Not a single social democrat argued against female voting rights in the analysed minutes. Furthermore, we find that the conservative arguments of principle were remarkably stable and essentially did not change during the 52 years our analysis covers. The postponement arguments varied more over time as some of the more common ones, such as the need for further investigation, lost credibility.
https://lup.lub.lu.se/record/94267565-a919-4faf-a892-6f0bc90fdc25
http://dx.doi.org/10.1007/978-3-031-52359-5_2
ISBN: 978-3-031-52359-5
ISBN: 978-3-031-52361-8
ISBN: 978-3-031-52358-8
scopus:85187415895
eng
Gender and Politics; pp 37-61 (2024)
ISSN: 2662-5822
ISSN: 2662-5814
Gender Studies
History
Political Science (excluding Public Administration Studies and Globalization Studies)
Resisting Democratisation : Arguments Against Female Enfranchisement Among Members of the Swedish Parliament 1866–1918
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text
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Short-term memory, attentional control and brain size in primates
https://lup.lub.lu.se/search/publication/1c3eaca1-5e9e-4194-8d62-499f10b04b65
van Schaik, Carel
Jacobs, Ivo
Burkart, Judith
Sauciuc, Gabriela-Alina
Schuppli, Caroline
Persson, Tomas
Song, Zitan
2024-03-07
Brain size variability in primates has been attributed to various domain-specific socio-ecological factors. A recently published large-scale study of short-term memory abilities in 41 primate species [1] did not find any correlations with 11 different proxies of external cognitive demands. Here we found that the interspecific variation in test performance shows correlated evolution with total brain size, with the relationship becoming tighter as species with small sample sizes were successively removed, whereas it was not predicted by the often-used encephalization quotient (EQ). In a subsample, we also found that the sizes of brain region thought to be involved in short-term memory did not predict performance better than did overall brain size. The dependence on brain size suggests that domain-general cognitive processes underlie short-term memory as tested in [1]. These results support the emerging notion that comparative studies of brain size do not generally identify domain-specific cognitive adaptations, but rather reveal varying selection on domain-general cognitive abilities. Finally, because attentional processes beyond short-term memory also affected test performance, we suggest that the delayed response test can be refined.
https://lup.lub.lu.se/record/1c3eaca1-5e9e-4194-8d62-499f10b04b65
eng
Royal Society Open Science; (2024)
ISSN: 2054-5703
Evolutionary Biology
Behavioral Sciences Biology
Psychology (excluding Applied Psychology)
Short-term memory, attentional control and brain size in primates
contributiontojournal/article
info:eu-repo/semantics/article
text
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Food safety and toxicology : Uncertainty analysis in human risk assessment from chemical exposure
https://lup.lub.lu.se/search/publication/91776059-43f2-46ed-9476-dbdbc9ca74d6
Sahlin, U.
Sand, S.
Wallace, H.
Galán-Madruga, David
2023
Uncertainty analysis should be an integral part of conducting a scientific investigation of the damaging human health effects of exposure to chemicals. Sources of uncertainty related to limitations in knowledge are present in all steps of a such risk assessment, i.e. the hazard identification, hazard characterization and exposure assessment. The purpose of uncertainty analysis is to evaluate the combined impact of these uncertainties on the risk characterization. The article describes ways to consider uncertainty in each of these steps, and different approaches of doing the assessment. Hazard characterization uncertainty is discussed, relying on two approaches: uncertainty factors and dose-response modelling. Uncertainties in exposure assessment fall into three broad categories: scenario uncertainty, model uncertainty, and exposure factor uncertainty. It is recommended to conduct an uncertainty analysis as a tiered approach, where the level of precision can be more refined by using more sophisticated methods, or efforts can be made to reduce uncertainty, until the degree of certainty cannot be further refined by the experts or is acceptable to decision makers as sufficient for risk management.
https://lup.lub.lu.se/record/91776059-43f2-46ed-9476-dbdbc9ca74d6
http://dx.doi.org/10.1016/B978-0-12-824315-2.01113-1
ISBN: 9780128243152
scopus:85188061115
eng
Environmental Sciences
Benchmark dose
Causal analysis
Dose-response model
Expert judgment
Exposure factor
Exposure model
Exposure scenario
Guidance value
Guideline value
Lowest observed adverse effect level
No observed adverse effect level
Overall uncertainty
Sensitivity analysis
Uncertainty analysis
Uncertainty factor
Food safety and toxicology : Uncertainty analysis in human risk assessment from chemical exposure
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text
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Management and documentation of pneumonia–a comparison of patients consulting primary care and emergency care
https://lup.lub.lu.se/search/publication/8628e096-942f-4e9e-b128-544deba8639b
Arntsberg, Louise
Fernberg, Sara
Berger, Ann Sofie
Hedin, Katarina
Moberg, Anna
2024
Patients may attend either primary or emergency care without referral in Sweden. Guidelines recommend a severity assessment, including assessment of vital signs, to be performed for all patients presenting with suspected pneumonia. Objective: To compare management and documentation of vital signs, symptoms and infection severity in pneumonia patients seeking primary care and emergency care without referral. Design: Medical record review of vital signs, examination findings and severity of pneumonia. Setting: Primary and emergency care. Subjects: Two hundred and forty patients diagnosed with pneumonia. Main outcome measures: Vital signs, examination findings and severity of pneumonia. Assessments of pneumonia severity according to the reviewers, the traffic light score and CRB-65. Results: Respiratory rate, blood pressure, heart rate and oxygen saturation were less often documented in primary care (p < .001). Chest X-ray was performed in 5% of primary care patients vs. 88% of emergency care patients (p < .01). Primary care patients had longer symptom duration, higher oxygen saturation and lower respiratory rate. In total, the reviewers assessed 63% of all pneumonias as mild and 9% as severe. The traffic light scoring model identified 11 patients (9%) in primary care and 53 patients (44%) in emergency care at high risk of severe infection. Conclusions: Vital signs were documented less often in primary care than in emergency care. Patients in primary care appear to have a less severe pneumonia, indicating attendance to the correct care level. The traffic light scoring model identified more patients at risk of severe infection than CRB-65, where the parameters were documented to a limited extent.
https://lup.lub.lu.se/record/8628e096-942f-4e9e-b128-544deba8639b
http://dx.doi.org/10.1080/02813432.2024.2326469
scopus:85187147202
eng
Scandinavian Journal of Primary Health Care; (2024)
ISSN: 0281-3432
Anesthesiology and Intensive Care
emergency care
Pneumonia
primary care
severity scoring
vital signs
Management and documentation of pneumonia–a comparison of patients consulting primary care and emergency care
contributiontojournal/article
info:eu-repo/semantics/article
text
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Animal migration in the Anthropocene : threats and mitigation options
https://lup.lub.lu.se/search/publication/04c0bb29-8038-4808-8031-866767108892
Cooke, Steven J.
Piczak, Morgan L.
Singh, Navinder J.
Åkesson, Susanne
Ford, Adam T.
Chowdhury, Shawan
Mitchell, Greg W.
Norris, D. Ryan
Hardesty-Moore, Molly
McCauley, Douglas
Hammerschlag, Neil
Tucker, Marlee A.
Horns, Joshua J.
Reisinger, Ryan R.
Kubelka, Vojtěch
Lennox, Robert J.
2024
Animal migration has fascinated scientists and the public alike for centuries, yet migratory animals are facing diverse threats that could lead to their demise. The Anthropocene is characterised by the reality that humans are the dominant force on Earth, having manifold negative effects on biodiversity and ecosystem function. Considerable research focus has been given to assessing anthropogenic impacts on the numerical abundance of species/populations, whereas relatively less attention has been devoted to animal migration. However, there are clear linkages, for example, where human-driven impacts on migration behaviour can lead to population/species declines or even extinction. Here, we explore anthropogenic threats to migratory animals (in all domains – aquatic, terrestrial, and aerial) using International Union for the Conservation of Nature (IUCN) Threat Taxonomy classifications. We reveal the diverse threats (e.g. human development, disease, invasive species, climate change, exploitation, pollution) that impact migratory wildlife in varied ways spanning taxa, life stages and type of impact (e.g. from direct mortality to changes in behaviour, health, and physiology). Notably, these threats often interact in complex and unpredictable ways to the detriment of wildlife, further complicating management. Fortunately, we are beginning to identify strategies for conserving and managing migratory animals in the Anthropocene. We provide a set of strategies that, if embraced, have the potential to ensure that migratory animals, and the important ecological functions sustained by migration, persist.
https://lup.lub.lu.se/record/04c0bb29-8038-4808-8031-866767108892
http://dx.doi.org/10.1111/brv.13066
scopus:85186909601
eng
Biological Reviews; (2024)
ISSN: 1464-7931
Ecology
animal movement
biodiversity
conservation
natural resources management
phenology
wildlife biology
Animal migration in the Anthropocene : threats and mitigation options
contributiontojournal/article
info:eu-repo/semantics/article
text
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Reflections on 30 years of publishing osteoarthritis research : Where we've been and where we're going
https://lup.lub.lu.se/search/publication/c36bce26-3e11-4eba-8976-03b0ebd49d7d
Yau, Michelle S.
Filbay, Stephanie R.
Block, Joel A.
Lohmander, L. Stefan
2024
https://lup.lub.lu.se/record/c36bce26-3e11-4eba-8976-03b0ebd49d7d
http://dx.doi.org/10.1016/j.joca.2024.02.008
scopus:85186855329
pmid:38401669
eng
Osteoarthritis and Cartilage; (2024)
ISSN: 1063-4584
Rheumatology and Autoimmunity
Reflections on 30 years of publishing osteoarthritis research : Where we've been and where we're going
contributiontojournal/comment
info:eu-repo/semantics/other
text
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Carbon removal and the empirics of climate delay
https://lup.lub.lu.se/search/publication/a00a165f-caba-40a3-95a8-d1f8eec1c8bb
Markusson, Nils
Buck, Holly Jean
Carton, Wim
Hougaard, Inge-Merete
Dooley, Kate
Lund, Jens Friis
2024
https://lup.lub.lu.se/record/a00a165f-caba-40a3-95a8-d1f8eec1c8bb
eng
Environmental Science and Policy; (2024)
ISSN: 1462-9011
Climate Research
Carbon removal and the empirics of climate delay
contributiontojournal/comment
info:eu-repo/semantics/other
text
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Diagnostic accuracy of prenatal ultrasound in coarctation of aorta : systematic review and individual participant data meta-analysis
https://lup.lub.lu.se/search/publication/7c9ae8aa-175f-4301-a46e-0d662ba07d94
Villalaín, C.
D'Antonio, F.
Flacco, M. E.
Gómez-Montes, E.
Herraiz, I.
Deiros-Bronte, L.
Maskatia, S. A.
Phillips, A. A.
Contro, E.
Fricke, K.
Bhawna, A.
Beattie, M. J.
Moon-Grady, A. J.
Durand, I.
Slodki, M.
Respondek-Liberska, M.
Patel, C.
Kawamura, H.
Rizzo, G.
Pagani, G.
Galindo, A.
2024
Objective: To determine the diagnostic accuracy of prenatal ultrasound in detecting coarctation of the aorta (CoA). Methods: An individual participant data meta-analysis was performed to report on the strength of association and diagnostic accuracy of different ultrasound signs in detecting CoA prenatally. MEDLINE, EMBASE and CINAHL were searched for studies published between January 2000 and November 2021. Inclusion criteria were fetuses with suspected isolated CoA, defined as ventricular and/or great vessel disproportion with right dominance on ultrasound assessment. Individual participant-level data were obtained by two leading teams. PRISMA-IPD and PRISMA-DTA guidelines were used for extracting data, and the QUADAS-2 tool was used for assessing quality and applicability. The reference standard was CoA, defined as narrowing of the aortic arch, diagnosed after birth. The most commonly evaluated parameters on ultrasound, both in B-mode and on Doppler, constituted the index test. Summary estimates of sensitivity, specificity, diagnostic odds ratio (DOR) and likelihood ratios were computed using the hierarchical summary receiver-operating-characteristics model. Results: The initial search yielded 72 studies, of which 25 met the inclusion criteria. Seventeen studies (640 fetuses) were included. On random-effects logistic regression analysis, tricuspid valve/mitral valve diameter ratio > 1.4 and > 1.6, aortic isthmus/arterial duct diameter ratio < 0.7, hypoplastic aortic arch (all P < 0.001), aortic isthmus diameter Z-score of < −2 in the sagittal (P = 0.003) and three-vessel-and-trachea (P < 0.001) views, pulmonary artery/ascending aorta diameter ratio > 1.4 (P = 0.048) and bidirectional flow at the foramen ovale (P = 0.012) were independently associated with CoA. Redundant foramen ovale was inversely associated with CoA (P = 0.037). Regarding diagnostic accuracy, tricuspid valve/mitral valve diameter ratio > 1.4 had a sensitivity of 72.6% (95% CI, 48.2–88.3%), specificity of 65.4% (95% CI, 46.9–80.2%) and DOR of 5.02 (95% CI, 1.82–13.9). The sensitivity and specificity values were, respectively, 75.0% (95% CI, 61.1–86.0%) and 39.7% (95% CI, 27.0–53.4%) for pulmonary artery/ascending aorta diameter ratio > 1.4, 47.8% (95% CI, 14.6–83.0%) and 87.6% (95% CI, 27.3–99.3%) for aortic isthmus diameter Z-score of < –2 in the sagittal view and 74.1% (95% CI, 58.0–85.6%) and 62.0% (95% CI, 41.6–78.9%) for aortic isthmus diameter Z-score of < –2 in the three-vessel-and-trachea view. Hypoplastic aortic arch had a sensitivity of 70.0% (95% CI, 42.0–88.6%), specificity of 91.3% (95% CI, 78.6–96.8%) and DOR of 24.9 (95% CI, 6.18–100). The diagnostic yield of prenatal ultrasound in detecting CoA did not change significantly when considering multiple categorical parameters. Five of the 11 evaluated continuous parameters were independently associated with CoA (all P < 0.001) but all had low-to-moderate diagnostic yield. Conclusions: Several prenatal ultrasound parameters are associated with an increased risk for postnatal CoA. However, diagnostic accuracy is only moderate, even when combinations of parameters are considered.
https://lup.lub.lu.se/record/7c9ae8aa-175f-4301-a46e-0d662ba07d94
http://dx.doi.org/10.1002/uog.27576
scopus:85186911917
eng
Ultrasound in Obstetrics and Gynecology; (2024)
ISSN: 0960-7692
Cardiac and Cardiovascular Systems
aortic arch anomaly
coarctation of the aorta
meta-analysis
prenatal diagnosis
systematic review
ultrasound
Diagnostic accuracy of prenatal ultrasound in coarctation of aorta : systematic review and individual participant data meta-analysis
contributiontojournal/systematicreview
info:eu-repo/semantics/article
text
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Do the respiration pulses induced by drying–rewetting matter for the soil–atmosphere carbon balance?
https://lup.lub.lu.se/search/publication/3d47339e-f564-49ee-886d-1498ad75c093
Rousk, Johannes
C. Brangarí, Albert
2022-03-30
https://lup.lub.lu.se/record/3d47339e-f564-49ee-886d-1498ad75c093
http://dx.doi.org/10.1111/gcb.16163
scopus:85127609133
pmid:35352861
eng
Global Change Biology; 28(11), pp 3486-3488 (2022)
ISSN: 1354-1013
Soil Science
Ecology
birch effect
carbon cycling
climate change
ecosystem drought
ecosystems
eddy covariance
soil microorganisms
soil moisture
Do the respiration pulses induced by drying–rewetting matter for the soil–atmosphere carbon balance?
contributiontojournal/article
info:eu-repo/semantics/article
text
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Minimal invasive LASER-resection vs. radiotherapy as primary treatment of early glottic cancer. A population-based study with, up to 16 years follow up of survival, rate of laryngectomy and voice function
https://lup.lub.lu.se/search/publication/dd4101ce-7f5b-4636-8498-3506dd2421eb
Rydell, Roland
Andreasson, Josefine
Gustafsson Baldwin, Sara
Clarhed, Nathalie
2024-01-31
BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.METHOD: A total of 268 patients with previously untreated T1-T2 glottic carcinoma were studied. They were primarily treated with either radiotherapy (n = 119) or laser resection (n = 149). Survival, need for additional treatment (radiotherapy and/or total layngectomi) and voice function was compared.RESULT: Median follow up time was 7 years with range 0.5-16.6. There was no difference in the overall survival (p = .065) or disease-specific survival. (p = .126). After radiotherapy 32/119 patients and after laser resection 57/149 patients had recurrence. Total rate of laryngectomy was 24% in the radiotherapy group, and 8% in the laser resection group (p = .001). Voice analysis (T1A) showed more roughness in the radiotherapy group, otherwise no difference.CONCLUSIONS: By reducing the surgical margins, we have achieved a better voice function (T1A) but more patients have needed repeated laser excisions and some have also needed supplementary radiotherapy. The risk of laryngectomy and survival were apparently not affected.
https://lup.lub.lu.se/record/dd4101ce-7f5b-4636-8498-3506dd2421eb
http://dx.doi.org/10.1080/00016489.2023.2299674
pmid:38294703
scopus:85184185030
eng
Acta Oto-Laryngologica; pp 1-7 (2024)
ISSN: 1651-2251
Surgery
Cancer and Oncology
Minimal invasive LASER-resection vs. radiotherapy as primary treatment of early glottic cancer. A population-based study with, up to 16 years follow up of survival, rate of laryngectomy and voice function
contributiontojournal/article
info:eu-repo/semantics/article
text
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The Theopolitics of the Migrant : Toward a Coalitional and Comparative Political Theology
https://lup.lub.lu.se/search/publication/6a0d11e5-19af-4497-a187-fd0a0ebe3b54
Allard, Silas W.
Heyer, Kristin
Nadella, Raj
Schmiedel, Ulrich
2021
Migration challenges democracies characterized by the assumption that the citizens who are affected by the law are also its authors and that the citizens who are its authors are also affected by the law. Taking the “hijab affair” in France as a point of departure, this chapter aims to confront the constitution of the law in decisionist political theology and dialectical political theology with the figure of the migrant. The chapter argues that the migrant can be characterized as a theopolitical figure that resists the separation of citizen and noncitizen implied in the concept of strong and stable state sovereignty. Drawing on Seyla Benhabib’s account of democratic iterations, the chapter sketches the contours of a coalitional and comparative political theology in order to provide a theological reflection and a theological rationale for the theopolitics of the migrant already practiced across Europe.
https://lup.lub.lu.se/record/6a0d11e5-19af-4497-a187-fd0a0ebe3b54
http://dx.doi.org/10.4324/9781003042198-15
ISBN: 9781003042198
ISBN: 9780367486693
ISBN: 9781032049526
scopus:85117219091
eng
Religious Studies
International Migration and Ethnic Relations
The Theopolitics of the Migrant : Toward a Coalitional and Comparative Political Theology
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text
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"No More Deaths" : Religious Liberty as a Defense for Providing Sanctuary for Immigrants
https://lup.lub.lu.se/search/publication/19e5c8be-51e7-4962-a062-7d1d7a1cc1c7
Allard, Silas
Heyer, Kristin
Nadella, Raj
Cuison Villazor, Rose
Schmiedel, Ulrich
2021
https://lup.lub.lu.se/record/19e5c8be-51e7-4962-a062-7d1d7a1cc1c7
ISBN: 9781003042198
ISBN: 9780367486693
scopus:85117209636
eng
Law and Religion; pp 251-275 (2021)
Religious Studies
"No More Deaths" : Religious Liberty as a Defense for Providing Sanctuary for Immigrants
contributiontobookanthology/chapter
info:eu-repo/semantics/bookPart
text