@article{0fd30671-2d51-40ac-898c-ec9bb30992a8,
  abstract     = {{<p>Pharbitis nil (L.) Choisy is a traditional medicinal plant exhibiting broad-spectrum pharmacological effects, including anti-cancer, renoprotective, and laxative effects; insecticidal activity; and antifungal, anti-inflammatory, antioxidant, neuroprotective, and hepatoprotective actions. In this study, 11 compounds were isolated from the seeds of the plant and structurally characterized. These included one novel benzodioxane derivative named pharbitan A (2), one phenolic compound (1), and nine caffeic acid derivatives (3–11). Bioactivity assays demonstrated that both fractions and isolated compounds from Pharbitis nil seeds significantly inhibited interleukin-4 and histamine secretion in phorbol 12-myristate 13-acetate/ionomycin-induced RBL-2H3 cells, as well as suppressed interlekin-1β production by lipopolysaccharide-stimulated RAW 264.7 macrophages. Notably, compounds 2 and 7 reduced cyclooxygenase-2 expression and modulated mitogen-activated protein kinase signaling pathways through inhibition of p38 MAPK and ERK phosphorylation. These results suggest that Pharbitis nil seeds and their constituents have notable anti-allergic and anti-inflammatory activities, highlighting their potential as natural therapeutic agents.</p>}},
  author       = {{Ha, Do Thi and Oanh, Nguyen Thi Kim and Khoa, Nguyen Manh and Hien, Tran Thi and Thu, Nguyen Thi and Thuy, Vu Huong and Van, Nguyen Huy and Luc, Tran Quang and Hue, Nguyen Thi Vinh}},
  issn         = {{1612-1872}},
  keywords     = {{anti-allergy; anti-inflammation; histamine; interlekin-1β; interlekin-4; Pharbitis nil}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Chemistry and Biodiversity}},
  title        = {{Anti-Allergic and Anti-Inflammatory Activities of a New Benzodioxane Derivative and Phenolic Compounds From Pharbitis nil Seeds}},
  url          = {{http://dx.doi.org/10.1002/cbdv.202502992}},
  doi          = {{10.1002/cbdv.202502992}},
  volume       = {{23}},
  year         = {{2026}},
}