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Vascular effects of calcitonin gene-related peptide (CGRP) and cholecystokinin (CCK) in the monkey eye

Almegård, Birgitta and Andersson, Sven LU (1993) In Journal of Ocular Pharmacology 9(1). p.77-84
Abstract
The effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on ocular blood flow were studied in monkeys using the labelled microsphere method. Intracameral administration of 800 pmole CGRP increased the blood flow significantly in the conjunctiva, ciliary body and sclera. There was no significant change in the choroid and retina. CCK-33 (800 pmole) caused no significant effects on the blood flow in the tissues examined, when compared to the control eyes. A miotic response was however noted, consistent with previous results. Neither peptide caused significant changes in the intraocular pressure. These results suggest that CGRP has a vasodilatory effect in some parts of the monkey eye, whereas CCK-33 is a miotic with no... (More)
The effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on ocular blood flow were studied in monkeys using the labelled microsphere method. Intracameral administration of 800 pmole CGRP increased the blood flow significantly in the conjunctiva, ciliary body and sclera. There was no significant change in the choroid and retina. CCK-33 (800 pmole) caused no significant effects on the blood flow in the tissues examined, when compared to the control eyes. A miotic response was however noted, consistent with previous results. Neither peptide caused significant changes in the intraocular pressure. These results suggest that CGRP has a vasodilatory effect in some parts of the monkey eye, whereas CCK-33 is a miotic with no marked effect on ocular blood flow. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Ocular Pharmacology
volume
9
issue
1
pages
77 - 84
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:8463735
  • scopus:0027514237
ISSN
8756-3320
language
English
LU publication?
yes
id
6e8408ed-3134-4ea6-9bc4-2c2e554c78dd (old id 1107673)
date added to LUP
2008-07-31 14:44:56
date last changed
2017-01-01 07:07:13
@article{6e8408ed-3134-4ea6-9bc4-2c2e554c78dd,
  abstract     = {The effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on ocular blood flow were studied in monkeys using the labelled microsphere method. Intracameral administration of 800 pmole CGRP increased the blood flow significantly in the conjunctiva, ciliary body and sclera. There was no significant change in the choroid and retina. CCK-33 (800 pmole) caused no significant effects on the blood flow in the tissues examined, when compared to the control eyes. A miotic response was however noted, consistent with previous results. Neither peptide caused significant changes in the intraocular pressure. These results suggest that CGRP has a vasodilatory effect in some parts of the monkey eye, whereas CCK-33 is a miotic with no marked effect on ocular blood flow.},
  author       = {Almegård, Birgitta and Andersson, Sven},
  issn         = {8756-3320},
  language     = {eng},
  number       = {1},
  pages        = {77--84},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Journal of Ocular Pharmacology},
  title        = {Vascular effects of calcitonin gene-related peptide (CGRP) and cholecystokinin (CCK) in the monkey eye},
  volume       = {9},
  year         = {1993},
}