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Gd-DTPA2)-enhanced MRI of femoral knee cartilage: a dose-response study in healthy volunteers

Tiderius, Carl Johan LU ; Olsson, Lars E.; de Verdier, Hans; Leander, Peter LU ; Ekberg, Olle LU and Dahlberg, Leif LU (2001) In Magnetic Resonance in Medicine 46(6). p.1067-1071
Abstract
The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an... (More)
The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an intravenous injection of Gd-DTPA2- at single, double, and triple doses: 0.1, 0.2, and 0.3 mmol/kg body weight, respectively. The increase in R1 postcontrast was linearly dose-related at all times. The highest R1 values were registered at 2 and 3 h postcontrast, suggesting 2 h to be optimal in the clinical situation. The triple dose indicated a subtle compartmental difference in men, with higher contrast distribution medially than laterally. Results suggest that the triple dose is needed to detect minor cartilage matrix differences. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cartilage, MRI, gadolinium, osteoarthritis, monitoring
in
Magnetic Resonance in Medicine
volume
46
issue
6
pages
1067 - 1071
publisher
Wiley Online Library
external identifiers
  • pmid:11746570
  • scopus:0034747168
ISSN
1522-2594
DOI
10.1002/mrm.1300
language
English
LU publication?
yes
id
b30c5309-f93e-4152-a485-c6393bbd5d15 (old id 1120196)
date added to LUP
2008-07-16 10:46:52
date last changed
2018-08-05 03:31:41
@article{b30c5309-f93e-4152-a485-c6393bbd5d15,
  abstract     = {The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an intravenous injection of Gd-DTPA2- at single, double, and triple doses: 0.1, 0.2, and 0.3 mmol/kg body weight, respectively. The increase in R1 postcontrast was linearly dose-related at all times. The highest R1 values were registered at 2 and 3 h postcontrast, suggesting 2 h to be optimal in the clinical situation. The triple dose indicated a subtle compartmental difference in men, with higher contrast distribution medially than laterally. Results suggest that the triple dose is needed to detect minor cartilage matrix differences.},
  author       = {Tiderius, Carl Johan and Olsson, Lars E. and de Verdier, Hans and Leander, Peter and Ekberg, Olle and Dahlberg, Leif},
  issn         = {1522-2594},
  keyword      = {cartilage,MRI,gadolinium,osteoarthritis,monitoring},
  language     = {eng},
  number       = {6},
  pages        = {1067--1071},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Gd-DTPA2)-enhanced MRI of femoral knee cartilage: a dose-response study in healthy volunteers},
  url          = {http://dx.doi.org/10.1002/mrm.1300},
  volume       = {46},
  year         = {2001},
}