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Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.

Niklasson, Bo; Heller, Knud E; Schønecker, Bryan; Bildsøe, Mogens; Daniels, Terri; Hampe, Christiane S; Widlund, Per; Simonson, William T; Schaefer, Jonathan B and Rutledge, Elizabeth, et al. (2003) In International journal of experimental diabesity research 4(1). p.35-44
Abstract
Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have... (More)
Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International journal of experimental diabesity research
volume
4
issue
1
pages
35 - 44
publisher
Taylor & Francis
external identifiers
  • scopus:0042008054
DOI
10.1080/15438600303733
language
English
LU publication?
yes
id
36c49321-1314-492d-9366-f3647b411806 (old id 1127426)
date added to LUP
2008-06-09 13:53:06
date last changed
2017-07-23 05:03:02
@article{36c49321-1314-492d-9366-f3647b411806,
  abstract     = {Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P &lt; .0001), IA-2 (P &lt; .0001), and insulin (P},
  author       = {Niklasson, Bo and Heller, Knud E and Schønecker, Bryan and Bildsøe, Mogens and Daniels, Terri and Hampe, Christiane S and Widlund, Per and Simonson, William T and Schaefer, Jonathan B and Rutledge, Elizabeth and Bekris, Lynn and Lindberg, A Michael and Johansson, Susanne and Ortqvist, Eva and Persson, Bengt and Lernmark, Åke},
  language     = {eng},
  number       = {1},
  pages        = {35--44},
  publisher    = {Taylor & Francis},
  series       = {International journal of experimental diabesity research},
  title        = {Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.},
  url          = {http://dx.doi.org/10.1080/15438600303733},
  volume       = {4},
  year         = {2003},
}