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Blood Pressure and Risk of Renal Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition

Weikert, S; Boeing, H; Pischon, T; Weikert, C; Olsen, A; Tjonneland, A; Overvad, K; Becker, N; Linseisen, J and Trichopoulou, A, et al. (2008) In American Journal of Epidemiology 167(4). p.438-446
Abstract
Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of... (More)
Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of systolic (>/=160 mmHg vs. <120 mmHg) and diastolic (>/=100 mmHg vs. <80 mmHg) blood pressures were 2.48 (95% confidence interval: 1.53, 4.02) and 2.34 (95% confidence interval: 1.54, 3.55). Risk estimates did not significantly differ according to sex or use of antihypertensive medication. Individuals taking antihypertensive drugs were not at a significantly increased risk unless blood pressure was poorly controlled. These results support the hypothesis that hypertension, rather than its medications, increases the risk of RCC in both sexes, while effective blood pressure control may lower the risk. (Less)
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American Journal of Epidemiology
volume
167
issue
4
pages
438 - 446
publisher
Oxford University Press
external identifiers
  • pmid:18048375
  • wos:000253246200009
  • scopus:39349107170
ISSN
0002-9262
DOI
10.1093/aje/kwm321
language
English
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yes
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16b168a6-3832-47ec-a1e7-a46a19faf6c8 (old id 1138892)
date added to LUP
2008-08-05 14:57:31
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@article{16b168a6-3832-47ec-a1e7-a46a19faf6c8,
  abstract     = {Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of systolic (&gt;/=160 mmHg vs. &lt;120 mmHg) and diastolic (&gt;/=100 mmHg vs. &lt;80 mmHg) blood pressures were 2.48 (95% confidence interval: 1.53, 4.02) and 2.34 (95% confidence interval: 1.54, 3.55). Risk estimates did not significantly differ according to sex or use of antihypertensive medication. Individuals taking antihypertensive drugs were not at a significantly increased risk unless blood pressure was poorly controlled. These results support the hypothesis that hypertension, rather than its medications, increases the risk of RCC in both sexes, while effective blood pressure control may lower the risk.},
  author       = {Weikert, S and Boeing, H and Pischon, T and Weikert, C and Olsen, A and Tjonneland, A and Overvad, K and Becker, N and Linseisen, J and Trichopoulou, A and Mountokalakis, T and Trichopoulos, D and Sieri, S and Palli, D and Vineis, P and Panico, S and Peeters, P and Bas Bueno-de-Mesquita, H and Verschuren, M and Ljungberg, B and Hallmans, G and Berglund, Göran and González, C and Dorronsoro, M and Barricarte, A and Tormo, M J and Allen, N and Roddam, A and Bingham, S and Khaw, K-T and Rinaldi, S and Ferrari, P and Norat, T and Riboli, E},
  issn         = {0002-9262},
  language     = {eng},
  number       = {4},
  pages        = {438--446},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Blood Pressure and Risk of Renal Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1093/aje/kwm321},
  volume       = {167},
  year         = {2008},
}