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Dynamics of T-peak-to-T-end Morphology Changes in an Open-chest Porcine Model, and its Relation to Arrhythmic Events

Gómez, Neurys ; Ramírez, Julia ; Tsvetkova, Alena S. ; Platonov, Pyotr LU ; Azarov, Jan E. ; Pablo Martínez, Juan and Laguna, Pablo (2024) 51st International Computing in Cardiology, CinC 2024 51.
Abstract

In this work, we use a time-warping-based morphology variation index, dwPCATpe, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes (VF group) in ECG recordings from 20 pigs undergoing a 40-minute coronary occlusion. The dwPCATpe series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and that of a reference T wave from a control recording. During occlusion, the absolute value of dwPCATpe followed a gradual increasing trend as ischemia progressed. At 0-5, 5-10, 10-15... (More)

In this work, we use a time-warping-based morphology variation index, dwPCATpe, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes (VF group) in ECG recordings from 20 pigs undergoing a 40-minute coronary occlusion. The dwPCATpe series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and that of a reference T wave from a control recording. During occlusion, the absolute value of dwPCATpe followed a gradual increasing trend as ischemia progressed. At 0-5, 5-10, 10-15 and 15-20 minutes after the occlusion onset, dwPCATpe median values were significantly higher in the VF group than in the non-VF group (10.2, 11.7, 18.2 and 19.0 vs 1.8, 2.4, 3.2 and 2.4 ms), with p-values from the Kruskal-Wallis test of 0.017, 0.041, 0.045 and 0.013, respectively. In contrast, the TPCApe index did not present significant differences in any of the intervals between VF and non-VF groups. In conclusion, dynamic increases of the dwPCATpe index during ischaemia progression in pigs are associated with VF occurrence.

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author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Computing in Cardiology
volume
51
conference name
51st International Computing in Cardiology, CinC 2024
conference location
Karlsruhe, Germany
conference dates
2024-09-08 - 2024-09-11
external identifiers
  • scopus:105028382738
DOI
10.22489/CinC.2024.453
language
English
LU publication?
yes
id
18c3d959-47e8-4172-b602-b1cdc9fccea2
date added to LUP
2026-02-27 11:33:54
date last changed
2026-02-27 11:34:58
@inproceedings{18c3d959-47e8-4172-b602-b1cdc9fccea2,
  abstract     = {{<p>In this work, we use a time-warping-based morphology variation index, d<sub>w</sub><sup>PCA</sup><sub>Tpe</sub>, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes (VF group) in ECG recordings from 20 pigs undergoing a 40-minute coronary occlusion. The d<sub>w</sub><sup>PCA</sup><sub>Tpe</sub> series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and that of a reference T wave from a control recording. During occlusion, the absolute value of d<sub>w</sub><sup>PCA</sup><sub>Tpe</sub> followed a gradual increasing trend as ischemia progressed. At 0-5, 5-10, 10-15 and 15-20 minutes after the occlusion onset, d<sub>w</sub><sup>PCA</sup><sub>Tpe</sub> median values were significantly higher in the VF group than in the non-VF group (10.2, 11.7, 18.2 and 19.0 vs 1.8, 2.4, 3.2 and 2.4 ms), with p-values from the Kruskal-Wallis test of 0.017, 0.041, 0.045 and 0.013, respectively. In contrast, the T<sup>PCA</sup><sub>pe</sub> index did not present significant differences in any of the intervals between VF and non-VF groups. In conclusion, dynamic increases of the d<sub>w</sub><sup>PCA</sup><sub>Tpe</sub> index during ischaemia progression in pigs are associated with VF occurrence.</p>}},
  author       = {{Gómez, Neurys and Ramírez, Julia and Tsvetkova, Alena S. and Platonov, Pyotr and Azarov, Jan E. and Pablo Martínez, Juan and Laguna, Pablo}},
  booktitle    = {{Computing in Cardiology}},
  language     = {{eng}},
  title        = {{Dynamics of T-peak-to-T-end Morphology Changes in an Open-chest Porcine Model, and its Relation to Arrhythmic Events}},
  url          = {{http://dx.doi.org/10.22489/CinC.2024.453}},
  doi          = {{10.22489/CinC.2024.453}},
  volume       = {{51}},
  year         = {{2024}},
}