@article{1fa10737-b3d0-45fa-8f4e-685f0b580c86,
  abstract     = {{<p>Introduction: Acute lower uncomplicated urinary tract infection (uUTI) affects a large proportion of women. Increased antimicrobial resistance has created an urgent need for novel therapeutics and the phytotherapeutic drug BNO 1045 (Canephron<sup>®</sup> N) has previously been shown to be noninferior to standard antimicrobial stewardship. This sub-analysis from a randomized, double-blind, controlled phase III noninferiority clinical trial using BNO 1045 versus fosfomycin to treat uUTI aimed to determine how urine cytokine levels are altered by the two different treatments. Methods: Urine samples from a predefined subset of women diagnosed with uUTI (18-70 years) and treated with BNO 1045 (n = 58) or fosfomycin (n = 69) were analyzed for urine levels of IL-6 and IL-8, using analyte-to-creatinine ratios. Results: BNO 1045 treatment showed similar effects to fosfomycin treatment in reducing both urine IL-6 and IL-8 levels. Mean IL-6 and IL-8 levels were markedly reduced in all patients regardless of treatment. BNO 1045 treatment decreased urine IL-8 significantly (p = 0.0142) and showed a trend toward reduction of urine IL-6 (p = 0.0551). Fosfomycin treatment reduced both IL-6 and IL-8 levels significantly (p = 0.0038, &lt;0.0001 respectively). Conclusion: BNO 1045 is, in addition to reducing symptoms, comparable to fosfomycin treatment in reducing the local inflammatory response associated with uUTI.</p>}},
  author       = {{Butler, Daniel S.C. and Wagenlehner, Florian and Höller, Martina and Abramov-Sommariva, Dimitri and Steindl, Hubert and Naber, Kurt G.}},
  issn         = {{0042-1138}},
  keywords     = {{BNO 1045; Phytotherapy; Uncomplicated urinary tract infection; Urine cytokines}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{8}},
  pages        = {{778--784}},
  publisher    = {{Karger}},
  series       = {{Urologia Internationalis}},
  title        = {{Phytotherapy (BNO 1045) of Acute Lower Uncomplicated Urinary Tract Infection in Women Normalizes Local Host Responses}},
  url          = {{http://dx.doi.org/10.1159/000531206}},
  doi          = {{10.1159/000531206}},
  volume       = {{107}},
  year         = {{2023}},
}