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Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors.

Jögi, Annika LU ; Vaapil, Marica LU ; Johansson, Martin and Påhlman, Sven LU (2012) In Uppsala Journal of Medical Sciences 117(2). p.217-224
Abstract
The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in surgical pathology, the contribution of differentiation-related gene expression and functions to tumor behavior is often overlooked in the experimental, tumor biological setting. The mechanisms by which tumor cell differentiation stages are perturbed or affected are poorly explored but have recently come into focus with the introduction.of the tumor stem cell concept. While developmental biologists view the differentiation as a... (More)
The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in surgical pathology, the contribution of differentiation-related gene expression and functions to tumor behavior is often overlooked in the experimental, tumor biological setting. The mechanisms by which tumor cell differentiation stages are perturbed or affected are poorly explored but have recently come into focus with the introduction.of the tumor stem cell concept. While developmental biologists view the differentiation as a unidirectional event, pathologists and tumor biologists have introduced the concept of dedifferentiation to explain phenotypic changes occurring in solid tumors. In this review we discuss the impact of the tumor cell differentiation stage as used in surgical pathology. We further discuss knowledge gained from exploring the molecular basis of the differentiation and dedifferentiation processes in neuroblastoma and breast cancer, two tumor forms where the tumor cell differentiation concept is used in the clinical diagnostic work and where the tumor stem cell theory has been applied. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Uppsala Journal of Medical Sciences
volume
117
issue
2
pages
217 - 224
publisher
Taylor & Francis
external identifiers
  • wos:000302949200015
  • pmid:22376239
  • scopus:84859926397
ISSN
0300-9734
DOI
10.3109/03009734.2012.659294
language
English
LU publication?
yes
id
7e23eeed-c88d-4dd2-a6e3-beb52a2da687 (old id 2432406)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22376239?dopt=Abstract
date added to LUP
2012-04-03 14:22:34
date last changed
2017-10-29 03:05:36
@article{7e23eeed-c88d-4dd2-a6e3-beb52a2da687,
  abstract     = {The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in surgical pathology, the contribution of differentiation-related gene expression and functions to tumor behavior is often overlooked in the experimental, tumor biological setting. The mechanisms by which tumor cell differentiation stages are perturbed or affected are poorly explored but have recently come into focus with the introduction.of the tumor stem cell concept. While developmental biologists view the differentiation as a unidirectional event, pathologists and tumor biologists have introduced the concept of dedifferentiation to explain phenotypic changes occurring in solid tumors. In this review we discuss the impact of the tumor cell differentiation stage as used in surgical pathology. We further discuss knowledge gained from exploring the molecular basis of the differentiation and dedifferentiation processes in neuroblastoma and breast cancer, two tumor forms where the tumor cell differentiation concept is used in the clinical diagnostic work and where the tumor stem cell theory has been applied.},
  author       = {Jögi, Annika and Vaapil, Marica and Johansson, Martin and Påhlman, Sven},
  issn         = {0300-9734},
  language     = {eng},
  number       = {2},
  pages        = {217--224},
  publisher    = {Taylor & Francis},
  series       = {Uppsala Journal of Medical Sciences},
  title        = {Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors.},
  url          = {http://dx.doi.org/10.3109/03009734.2012.659294},
  volume       = {117},
  year         = {2012},
}