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The microbiota of the gut in preschool children with normal and excessive body weight.

Karlsson, Caroline LU ; Önnerfält, Jenny LU ; Xu, Jie; Molin, Göran; Ahrné, Siv and Thorngren-Jerneck, Kristina LU (2012) In Obesity
Abstract
The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and obesity. Twenty overweight or obese children and twenty children with body mass index within the normal range (age: 4-5 years) were recruited from the south of Sweden. The gut microbiota was accessed by quantitative polymerase chain reactions and terminal restriction fragment length polymorphism and calprotectin was measured in faeces. Liver enzymes were quantified in obese/overweight children. The concentration of the Gram-negative family Enterobacteriaceae was significantly higher in the obese/overweight children (P=0.036) while levels of Desulfovibrio and Akkermansia muciniphila-like bacteria were significantly lower in the... (More)
The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and obesity. Twenty overweight or obese children and twenty children with body mass index within the normal range (age: 4-5 years) were recruited from the south of Sweden. The gut microbiota was accessed by quantitative polymerase chain reactions and terminal restriction fragment length polymorphism and calprotectin was measured in faeces. Liver enzymes were quantified in obese/overweight children. The concentration of the Gram-negative family Enterobacteriaceae was significantly higher in the obese/overweight children (P=0.036) while levels of Desulfovibrio and Akkermansia muciniphila-like bacteria were significantly lower in the obese/overweight children (P=0.027 and P=0.030, respectively). No significant differences were found in content of Lactobacillus, Bifidobacterium or the Bacteroides fragilis group. The diversity of the dominating bacterial community tended to be less diverse in the obese/overweight group, but the difference was not statistically significant. Concentration of Bifidobacterium was inversely correlated to alanine aminotransferase in obese/overweight children. The faecal levels of calprotectin did not differ between the study groups. These findings indicate that the gut microbiota differed among preschool children with obesity/overweight compared with children with body mass index within the normal range. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Obesity
publisher
Nature Publishing Group
external identifiers
  • wos:000310492200013
  • pmid:22546742
  • scopus:84868197954
ISSN
1930-739X
DOI
10.1038/oby.2012.110
language
English
LU publication?
yes
id
78f6bb22-1817-4255-b69b-96108d19ca6f (old id 2609301)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22546742?dopt=Abstract
date added to LUP
2012-06-02 15:31:05
date last changed
2017-11-05 04:41:52
@article{78f6bb22-1817-4255-b69b-96108d19ca6f,
  abstract     = {The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and obesity. Twenty overweight or obese children and twenty children with body mass index within the normal range (age: 4-5 years) were recruited from the south of Sweden. The gut microbiota was accessed by quantitative polymerase chain reactions and terminal restriction fragment length polymorphism and calprotectin was measured in faeces. Liver enzymes were quantified in obese/overweight children. The concentration of the Gram-negative family Enterobacteriaceae was significantly higher in the obese/overweight children (P=0.036) while levels of Desulfovibrio and Akkermansia muciniphila-like bacteria were significantly lower in the obese/overweight children (P=0.027 and P=0.030, respectively). No significant differences were found in content of Lactobacillus, Bifidobacterium or the Bacteroides fragilis group. The diversity of the dominating bacterial community tended to be less diverse in the obese/overweight group, but the difference was not statistically significant. Concentration of Bifidobacterium was inversely correlated to alanine aminotransferase in obese/overweight children. The faecal levels of calprotectin did not differ between the study groups. These findings indicate that the gut microbiota differed among preschool children with obesity/overweight compared with children with body mass index within the normal range.},
  author       = {Karlsson, Caroline and Önnerfält, Jenny and Xu, Jie and Molin, Göran and Ahrné, Siv and Thorngren-Jerneck, Kristina},
  issn         = {1930-739X},
  language     = {eng},
  month        = {05},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {The microbiota of the gut in preschool children with normal and excessive body weight.},
  url          = {http://dx.doi.org/10.1038/oby.2012.110},
  year         = {2012},
}