Advanced

Malaria, Immunity, and Immunopathology

Persson, Kristina E.M. LU (2016) 4. p.94-100
Abstract

Malaria is a disease spread by mosquitoes, and it is a major global cause of morbidity and mortality. Most of the deaths in malaria are caused by the Apicomplexan parasite Plasmodium falciparum. Immunity against the disease is dependent on repeated exposure, and it usually takes several years to develop. Antibodies against different antigens are an important part of immunity, but cellular immunity has also been shown to be of importance. There is no licensed vaccine against malaria, and one of the reasons for this is that knowledge about how immunity is developed is still lacking. In this article, we go through the different stages of the life cycle of the parasite and explain what is known about immunity against different antigens from... (More)

Malaria is a disease spread by mosquitoes, and it is a major global cause of morbidity and mortality. Most of the deaths in malaria are caused by the Apicomplexan parasite Plasmodium falciparum. Immunity against the disease is dependent on repeated exposure, and it usually takes several years to develop. Antibodies against different antigens are an important part of immunity, but cellular immunity has also been shown to be of importance. There is no licensed vaccine against malaria, and one of the reasons for this is that knowledge about how immunity is developed is still lacking. In this article, we go through the different stages of the life cycle of the parasite and explain what is known about immunity against different antigens from the preerythrocytic and erythrocytic stages. We also mention different host factors, which can affect the outcome of malaria.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Knobs, Malaria, Merozoites, Plasmodium, Plasmodium falciparum, Plasmodium knowlesi, Plasmodium malariae, Plasmodium ovale, Plasmodium vivax, Sporozoites
host publication
Encyclopedia of Immunobiology
editor
BIRON, C. A.; FINN, O. J.; KAYE, P. M.; ; and
volume
4
pages
7 pages
publisher
Elsevier Inc.
external identifiers
  • scopus:85043241854
ISBN
9780080921525
DOI
10.1016/B978-0-12-374279-7.13007-3
language
English
LU publication?
yes
id
40669c73-f2b6-4fef-bee2-4ec0a9a59d12
date added to LUP
2018-03-26 14:12:54
date last changed
2019-01-06 13:48:53
@inbook{40669c73-f2b6-4fef-bee2-4ec0a9a59d12,
  abstract     = {<p>Malaria is a disease spread by mosquitoes, and it is a major global cause of morbidity and mortality. Most of the deaths in malaria are caused by the Apicomplexan parasite Plasmodium falciparum. Immunity against the disease is dependent on repeated exposure, and it usually takes several years to develop. Antibodies against different antigens are an important part of immunity, but cellular immunity has also been shown to be of importance. There is no licensed vaccine against malaria, and one of the reasons for this is that knowledge about how immunity is developed is still lacking. In this article, we go through the different stages of the life cycle of the parasite and explain what is known about immunity against different antigens from the preerythrocytic and erythrocytic stages. We also mention different host factors, which can affect the outcome of malaria.</p>},
  author       = {Persson, Kristina E.M.},
  editor       = {BIRON, C. A. and FINN, O. J. and KAYE, P. M.},
  isbn         = {9780080921525},
  keyword      = {Knobs,Malaria,Merozoites,Plasmodium,Plasmodium falciparum,Plasmodium knowlesi,Plasmodium malariae,Plasmodium ovale,Plasmodium vivax,Sporozoites},
  language     = {eng},
  month        = {04},
  pages        = {94--100},
  publisher    = {Elsevier Inc.},
  title        = {Malaria, Immunity, and Immunopathology},
  url          = {http://dx.doi.org/10.1016/B978-0-12-374279-7.13007-3},
  volume       = {4},
  year         = {2016},
}