@article{4c0eaf33-36c4-4cbd-afb5-0a5214048adc,
  abstract     = {{Background<br/>Obesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&amp;E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.<br/>Methods<br/>We classified 489,311 UK Biobank participants into five risk groups (Groups 1–5) with increasingly adverse adiposity profiles based on BF%–WC. Associations with three-point major adverse cardiovascular events (3P-MACE), type 2 diabetes (T2D), and chronic kidney disease (CKD) were estimated using cumulative incidence and Cox PH models. Comparison with BMI categories was visualised with an alluvial plot.<br/>Findings<br/>Over a median 13.1 years (IQR 1.7), 24,778 (5.1%) participants experienced 3P-MACE, 30,376 (6.2%) had incident T2D, and 14,906 (3.0%) had incident CKD. The BF%–WC classification yielded stepwise risk stratification across endpoints. Compared to the reference Group 1, Group 5 had significantly higher risk: age- and sex-adjusted HR 9.23 (95% CI 8.70–9.83) for T2D, 2.27 (2.10–2.41) for CKD, and 1.63 (1.60–1.71) for 3P-MACE. Discordance with BMI was notable: 32.6% of individuals in the high-risk Group 5 had a BMI in the normal-to-overweight range, while the overweight category spanned all BF%–WC risk groups.<br/>Interpretation<br/>An adiposity-based classification integrating BF% and WC associates significantly with cardiometabolic and kidney outcomes and reveals discordance with BMI, reinforcing the Commission’s framing of obesity as a disease driven by excess adiposity.}},
  author       = {{Gunnarsson, Sophie and Karlsson, Cecilia and Prasad, Rashmi and Hansson, Sara}},
  issn         = {{2352-3964}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{1--10}},
  publisher    = {{Elsevier}},
  series       = {{EBioMedicine}},
  title        = {{Adiposity-based obesity classification and cardiometabolic and kidney outcomes: a longitudinal UK Biobank analysis}},
  url          = {{http://dx.doi.org/10.1016/j.ebiom.2026.106272}},
  doi          = {{10.1016/j.ebiom.2026.106272}},
  year         = {{2026}},
}