@article{55e1e219-7c26-4336-a3b9-089800ff8346,
  abstract     = {{<p>BACKGROUND Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). However, this treatment carries a significant risk of acute kidney injury (AKI), especially with cisplatin-based regimens. Sodium thiosulfate (ST) is established as a nephroprotective treatment in cisplatin-based HIPEC, but its efficacy in oxaliplatin-based HIPEC remains unexplored. AIM To evaluate the protective effects of ST in patients undergoing oxaliplatin-based HIPEC for colorectal PC. METHODS This retrospective single-center study included 119 patients who underwent CRS combined with oxaliplatin-based HIPEC for colorectal PC between 2018 and 2024. ST was introduced in 2022, and patients were grouped as ST-treated (n = 46) and non-ST-treated (n = 73) based on the treatment period. The primary endpoint was the incidence of AKI. Secondary outcomes were postoperative plasma creatinine levels, estimated glomerular filtration rate, severity of AKI, and rate of postoperative complications. Outcomes were analyzed using multivariate logistic regression, including sensitivity analysis. RESULTS The incidence of AKI was significantly lower in the ST-treated group (28%) compared with the non-ST-treated group (66%). Multivariate analysis confirmed ST as an independent factor associated with a reduced risk of AKI. Peak plasma creatinine and mean postoperative creatinine levels were also significantly lower in the ST-treated group. The rate of postoperative complications other than AKI was similar between the groups. CONCLUSION Prophylactic administration of ST significantly reduces the incidence and severity of AKI in patients undergoing CRS combined with oxaliplatin-based HIPEC. These findings suggest that ST may be considered as a nephroprotective strategy in oxaliplatin-based HIPEC protocols; however, further prospective studies are warranted to confirm these results.</p>}},
  author       = {{Algethami, Nader and Valdimarsson, Valentinus and Verwaal, Victor and Syk, Ingvar}},
  keywords     = {{Acute kidney injury; Hyperthermic intraperitoneal chemotherapy; Oxaliplatin; Peritoneal carcinomatosis; Peritoneal surface malignancy; Sodium thiosulfate}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{1--13}},
  publisher    = {{Baishideng Publishing Group Inc}},
  series       = {{World Journal of Gastrointestinal Oncology}},
  title        = {{Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy}},
  url          = {{http://dx.doi.org/10.4251/wjgo.v18.i7.118400}},
  doi          = {{10.4251/wjgo.v18.i7.118400}},
  volume       = {{18}},
  year         = {{2026}},
}