@inproceedings{659efc80-3137-4b8c-98f0-a67f8ca6f97b,
  abstract     = {{<p>By optically sensing mid-infrared absorption through a visible probe beam, mid-infrared photothermal (MIP) microscopy has emerged as a powerful tool for chemical imaging with micromolar sensitivity and submicron spatial resolution. The adoption of spatially multiplexed camera-based widefield detection further enhanced the imaging speed. However, current widefield MIP systems suffer from a small field of view (FOV)—typically tens of square micrometers, which constrains their utility in large-area tissue imaging applications. Here, we report a laser-scan MIP mesoscope that achieves millimeter-scale FOV while preserving submicron resolution. By leveraging an all-reflective laser scanning architecture, low-magnification and medium numerical-aperture objectives, and a defocused signal collection scheme, our MIP mesoscope achieves a 1.2 × 1.2 mm<sup>2</sup> FOV, 650 nm lateral resolution, and microsecond-scale pixel dwell time. In vivo chemical imaging of whole Caenorhabditis elegans and high-throughput detection of beta-amyloids in both mouse and human brain tissues associated with Alzheimer’s disease are demonstrated.</p>}},
  author       = {{Tang, Rong and Yin, Jiaze and Weinberg, Bethany and Lin, Haonan and Lu, Jiahui and Gate, David and Klementieva, Oxana and Cheng, Ji Xin}},
  booktitle    = {{Advanced Chemical Microscopy for Life Science and Translational Medicine 2026}},
  editor       = {{Cheng, Ji-Xin and Min, Wei and Simpson, Garth J.}},
  isbn         = {{9781510696419}},
  issn         = {{1605-7422}},
  language     = {{eng}},
  publisher    = {{SPIE}},
  series       = {{Progress in Biomedical Optics and Imaging - Proceedings of SPIE}},
  title        = {{Mid-Infrared Photothermal Mesoscopy with Millimeter Field of View and Sub-micron Spatial Resolution}},
  url          = {{http://dx.doi.org/10.1117/12.3079290}},
  doi          = {{10.1117/12.3079290}},
  volume       = {{13864}},
  year         = {{2026}},
}