@article{80fbf635-23df-481a-b8c4-08e0de474ac0,
abstract = {{Spontaneous neuronal activity and concomitant intracellular Ca2+
signaling are abundant during early perinatal development and are well
known for their key role in neuronal proliferation, migration,
differentiation and wiring. However, much less is known about the in
vivo patterns of spontaneous Ca2+ signaling in immature adult-born cells. Here, by using two-photon Ca2+ imaging, we analyzed spontaneous in vivo Ca2+
signaling in adult-born juxtaglomerular cells of the mouse olfactory
bulb over the time period of 5 weeks, from the day of their arrival in
the glomerular layer till their stable integration into the preexisting
neural network. We show that spontaneous Ca2+ transients are ubiquitously present in adult-born cells right after their arrival, require activation of voltage-gated Na+
channels and are little sensitive to isoflurane anesthesia.
Interestingly, several parameters of this spontaneous activity, such as
the area under the curve, the time spent in the active state as well as
the fraction of continuously active cells show a bell-shaped dependence
on cell's age, all peaking in 3-4 weeks old cells. This data firmly
document the in vivo presence of spontaneous Ca2+ signaling
during the layer-specific maturation of adult-born neurons in the
olfactory bulb and motivate further analyses of the functional role(s)
of this activity.
}},
author = {{Maslyukov, Anatoliy and Li, Kaizhen and Su, Xin and Kovalchuk, Yury and Garaschuk, Olga}},
issn = {{0143-4160}},
language = {{eng}},
pages = {{43--52}},
publisher = {{Elsevier}},
series = {{Cell Calcium}},
title = {{Spontaneous calcium transients in the immature adult-born neurons of the olfactory bulb}},
url = {{http://dx.doi.org/10.1016/j.ceca.2018.06.001}},
doi = {{10.1016/j.ceca.2018.06.001}},
volume = {{74}},
year = {{2018}},
}