@article{95f88d95-a058-4fa7-978e-d8a1b0d13c60,
  abstract     = {{Despite rapid clinical translation, induced pluripotent stem cell (iPSC)-derived therapies face limited global adoption. Harmonized quality control (QC) remains absent, with even fundamental parameters evaluated inconsistently across laboratories. To address this, we conducted two international Quality Assessment Rounds (QARs): QAR 2019 (18 sites, 11 countries) and QAR 2023 (23 sites, 12 countries), evaluating flow cytometry-based assessment of the undifferentiated state and qPCR-based genomic integrity testing. QAR 2019 showed high consistency in genomic integrity testing, while uncovering substantial variability in flow cytometry, prompting QAR 2023 to introduce standardized workflows. These improvements enabled systematic, cross-site evaluation of marker performance across cell states, identifying OCT3/4, TRA-1-60, and SSEA5 as consistently robust pluripotency-associated markers. This global benchmarking effort provides the first empirical multi-site evidence for reproducible iPSC QC and marker-level reliability. Together, these findings establish a foundation for harmonized QC supporting interoperable iPSC banks, regulatory alignment, and scalable manufacturing of globally accessible regenerative therapies.}},
  author       = {{Hägg, Alice and Wood, Rachel and Mochizuki, Ayako L. and Abberton, Keren and Abranches, Elsa and Alvarez-Palomo, Belén and Baptista, Ricardo and Quintanilha Barbosa, Raiana Andrade and Barry, Jacqueline and Carvalho, Adriana Bastos and Bennaceur Griscelli, Annelise and Campos de Carvalho, Antonio Carlos and Chaker, Diana and Chang, Hong and Choi, Hye Young and Codinach, Margarita and Arán Corbella, Begoña and Cowan, Scott and Dickerson, Sarah Jane and Elwood, Ngaire and Fan, Xueling and Feyeux, Maxime and Forrester, Maddy and Gaffney, Andrew and Guilbert, Solenn M. and Ha, Hye-Yeong and Hirst, Adam J. and Hunter, Arwen L. and Jamieson, Leanne G. and Judson, Robert N. and Kanemura, Yonehiro and Kasai-Brunswick, Tais Hanae and Kim, Jung-Hyun and Kim, Howard and Kintali, Manisha and Krishnan, Siddharth and Kuebler, Bernd and Lau, Chui Yu and Li, Wilson and Mack, Amanda and MacLeod, Michael R. and Madrid, Marinna and Mamiya, Hiroaki and Manache-Alberici, Lucie and Mărginean, Dragoş and Mentre, Olivier and Morgan, Stefanie L. and Mountford, Joanne and Munir, Humayun and Ng, Siemon H.S. and Ogawa, Haruna and Oh, Steve and Ohara, Hidetaka and Oono, Keiko and Park, Niall and Pereira, Lygia V. and Pereira da Silva Bezerra, Izabella and Podovei, Alexandru Robert and Querol, Sergio and Raje, Jainy and Raya, Angel and Sakamoto, Satoko and Sarafian, Raquel and Schmit, Kathleen and Selvitella, Silvia and Singh, Gurbind and Smart, Matthew J.K. and Song, Jihwan and Stacey, Glyn and Sullivan, Stephen and Sumida, Miho and Terrenoire, Cecile and Tian, Pei and Uhlin, Elias and Vaquero, José M.A. and Veiga, Anna and Vicky Wang, Jar Wei and Warre-Cornish, Katherine and Wood, Jamie and Yamamoto, Atsuyo and Zhang, Gaojun and Hikichi, Takafusa and Turner, Marc and Falk, Anna}},
  issn         = {{2213-6711}},
  language     = {{eng}},
  month        = {{03}},
  pages        = {{1--16}},
  publisher    = {{Cell Press}},
  series       = {{Stem Cell Reports}},
  title        = {{Toward standardized iPSC testing: Insights from a multi-year international Quality Assessment Round}},
  url          = {{http://dx.doi.org/10.1016/j.stemcr.2026.102857}},
  doi          = {{10.1016/j.stemcr.2026.102857}},
  year         = {{2026}},
}